Email this article Synuclein Deficiency Decreases the Efficiency of Dopamine Uptake by Synaptic Vesicles
- Authors: Ninkina N.N.1,2, Tarasova T.V.1,2, Chaprov K.D.1, Goloborshcheva V.V.1, Bachurin S.O.1, Buchman V.L.1,2
-
Affiliations:
- Institute of Physiologically Active Compounds, Russian Academy of Sciences
- Cardiff University, School of Biosciences, Sir Martin Evans Building, Museum Avenue
- Issue: Vol 486, No 1 (2019)
- Pages: 168-170
- Section: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/212988
- DOI: https://doi.org/10.1134/S1607672919030025
- ID: 212988
Cite item
Open Access
Access granted
Subscription Access
Abstract
In the present study, we analyzed the uptake of radiolabeled dopamine by intact synaptosomes and purified synaptic vesicles isolated from the dorsal striatum of mice with constitutive inactivation of all three synuclein-coding genes and wild-type mice. Synuclein deficiency substantially compromised the uptake of this neurotransmitter by synaptic vesicles but had no effect on synaptosomal dopamine uptake.
About the authors
N. N. Ninkina
Institute of Physiologically Active Compounds,Russian Academy of Sciences; Cardiff University, School of Biosciences,
Sir Martin Evans Building, Museum Avenue
Email: chapkir@gmail.com
Russian Federation, Chernogolovka,
Moscow oblast, 142432; Cardiff,
CF10 3AX
T. V. Tarasova
Institute of Physiologically Active Compounds,Russian Academy of Sciences; Cardiff University, School of Biosciences,
Sir Martin Evans Building, Museum Avenue
Email: chapkir@gmail.com
Russian Federation, Chernogolovka,
Moscow oblast, 142432; Cardiff,
CF10 3AX
K. D. Chaprov
Institute of Physiologically Active Compounds,Russian Academy of Sciences
Author for correspondence.
Email: chapkir@gmail.com
Russian Federation, Chernogolovka,
Moscow oblast, 142432
V. V. Goloborshcheva
Institute of Physiologically Active Compounds,Russian Academy of Sciences
Email: chapkir@gmail.com
Russian Federation, Chernogolovka,
Moscow oblast, 142432
S. O. Bachurin
Institute of Physiologically Active Compounds,Russian Academy of Sciences
Email: chapkir@gmail.com
Russian Federation, Chernogolovka,
Moscow oblast, 142432
V. L. Buchman
Institute of Physiologically Active Compounds,Russian Academy of Sciences; Cardiff University, School of Biosciences,
Sir Martin Evans Building, Museum Avenue
Email: chapkir@gmail.com
Russian Federation, Chernogolovka,
Moscow oblast, 142432; Cardiff,
CF10 3AX
Supplementary files
