Email this article Peroxide-Induced Oxidative Modification of Hemoglobin
- Authors: Vasilyeva A.D.1, Yurina L.V.1, Bugrova A.E.1, Indeykina M.I.1,2, Azarova D.Y.1,3, Bychkova A.V.1, Akzhigitova K.I.1,4, Kononikhin A.S.1,5,2, Nikolaev E.N.1,5,6, Rosenfeld M.A.1
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Affiliations:
- Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
- Moscow Institute of Physics and Technology
- Skryabin Moscow State Academy of Veterinary Medicine, and Biotechnology
- Belinsky Pedagogical Institute, Penza State University
- Tal’roze Institute for Energy Problems of Chemical Physics, Russian Academy of Sciences
- Skolkovo Institute of Science and Technology
- Issue: Vol 486, No 1 (2019)
- Pages: 197-200
- Section: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/213012
- DOI: https://doi.org/10.1134/S1607672919030116
- ID: 213012
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Abstract
The oxidative modification of human hemoglobin (Hb) treated with hydrogen peroxide was investigated. Using the mass spectrometry method, the oxidized amino acid residues of the hemoglobin molecule were detected: αTrp14, αTyr24, αArg31, αMet32, αTyr42, αHis45, αHis72, αMet76, αPro77, αLys90, αCys104, αTyr140, βHis2, βTrp15, βTrp37, βMet55, βCys93, βCys112, βTyr130, βLys144, and βHis146. The antioxidant potential of the Hb molecule in the intracellular space and in the blood plasma is discussed.
About the authors
A. D. Vasilyeva
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Author for correspondence.
Email: ms.kadaver@mail.ru
Russian Federation, Moscow, 119334
L. V. Yurina
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: ms.kadaver@mail.ru
Russian Federation, Moscow, 119334
A. E. Bugrova
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: ms.kadaver@mail.ru
Russian Federation, Moscow, 119334
M. I. Indeykina
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences; Moscow Institute of Physics and Technology
Email: ms.kadaver@mail.ru
Russian Federation, Moscow, 119334; Dolgoprudnyi, Moscow oblast, 141701
D. Y. Azarova
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences; Skryabin Moscow State Academy of Veterinary Medicine, and Biotechnology
Email: ms.kadaver@mail.ru
Russian Federation, Moscow, 119334; Moscow
A. V. Bychkova
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: ms.kadaver@mail.ru
Russian Federation, Moscow, 119334
K. I. Akzhigitova
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences; Belinsky Pedagogical Institute, Penza State University
Email: ms.kadaver@mail.ru
Russian Federation, Moscow, 119334; Penza
A. S. Kononikhin
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences; Tal’roze Institute for Energy Problems of Chemical Physics, Russian Academy of Sciences; Moscow Institute of Physics and Technology
Email: ms.kadaver@mail.ru
Russian Federation, Moscow, 119334; Moscow, 119334; Dolgoprudnyi, Moscow oblast, 141701
E. N. Nikolaev
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences; Tal’roze Institute for Energy Problems of Chemical Physics, Russian Academy of Sciences; Skolkovo Institute of Science and Technology
Email: ms.kadaver@mail.ru
Russian Federation, Moscow, 119334; Moscow, 119334; Skolkovo, Moscow oblast, 143025
M. A. Rosenfeld
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: ms.kadaver@mail.ru
Russian Federation, Moscow, 119334
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