Email this article Anticancer Activity of Dinitrosyl Iron Complex (NO Donor) on the Multiple Myeloma Cells
- Authors: Akentieva N.P.1,2, Sanina N.A.1,3, Prichodchenko T.R.1, Gizatullin A.R.1, Shkondina N.I.1, Shushanov S.S.4, Stupina T.S.1,2, Aldoshin S.M.1,3
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Affiliations:
- Institute of Problems of Chemical Physics, Russian Academy of Sciences
- Scientific and Educational Center Medical Chemistry, Moscow State Regional University
- Moscow State University
- Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation
- Issue: Vol 486, No 1 (2019)
- Pages: 238-242
- Section: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/213051
- DOI: https://doi.org/10.1134/S1607672919030190
- ID: 213051
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Abstract
The results of the study of the effect of a mononuclear dinitrosyl iron complex (DNIC7) with functional sulfur-containing ligands (NO donors) on the viability of multiple myeloma cells are presented. It was shown that DNIC7 decreased cell viability and inhibited the proliferation of multiple myeloma cells, i.e., exhibits cytotoxic properties. Fluorescent analysis showed that the DNIC7 compound decreases the level of intracellular glutathione and increases the level of reactive oxygen species in multiple myeloma cells. It is assumed that DNIC7 has a therapeutic potential for the treatment of cancer.
About the authors
N. P. Akentieva
Institute of Problems of Chemical Physics, Russian Academy of Sciences; Scientific and Educational Center Medical Chemistry, Moscow State Regional University
Author for correspondence.
Email: na_aken@icp.ac.ru
Russian Federation, Chernogolovka, Moscow oblast, 142432; Moscow, Moscow oblast,
142432
N. A. Sanina
Institute of Problems of Chemical Physics, Russian Academy of Sciences; Moscow State University
Email: na_aken@icp.ac.ru
Russian Federation, Chernogolovka, Moscow oblast, 142432; Moscow
T. R. Prichodchenko
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: na_aken@icp.ac.ru
Russian Federation, Chernogolovka, Moscow oblast, 142432
A. R. Gizatullin
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: na_aken@icp.ac.ru
Russian Federation, Chernogolovka, Moscow oblast, 142432
N. I. Shkondina
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: na_aken@icp.ac.ru
Russian Federation, Chernogolovka, Moscow oblast, 142432
S. S. Shushanov
Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation
Email: na_aken@icp.ac.ru
Russian Federation, Moscow, 115478
T. S. Stupina
Institute of Problems of Chemical Physics, Russian Academy of Sciences; Scientific and Educational Center Medical Chemistry, Moscow State Regional University
Email: na_aken@icp.ac.ru
Russian Federation, Chernogolovka, Moscow oblast, 142432; Moscow, Moscow oblast,
142432
S. M. Aldoshin
Institute of Problems of Chemical Physics, Russian Academy of Sciences; Moscow State University
Email: na_aken@icp.ac.ru
Russian Federation, Chernogolovka, Moscow oblast, 142432; Moscow
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