Activation of Su(Hw)-Controlled Genes Is Associated with Increase in GAF Binding

P. V. Elizar’ev; D. A. Chetverina; L. S. Melnikova; A. Srivastava; R. K. Mishra; A. K. Golovnin; P. G. Georgiev; M. M. Erokhin

doi:10.1134/S1607672919050016

Activation of Su(Hw)-Controlled Genes Is Associated with Increase in GAF Binding

Authors: Elizar’ev P.V.¹, Chetverina D.A.¹, Melnikova L.S.¹, Srivastava A.², Mishra R.K.², Golovnin A.K.¹, Georgiev P.G.¹, Erokhin M.M.¹
Affiliations:
1. Institute of Gene Biology, Russian Academy of Sciences
2. CSIR—Center for Cellular and Molecular Biology (CCMB)
Issue: Vol 488, No 1 (2019)
Pages: 293-295
Section: Biochemistry, Biophysics, and Molecular Biology
URL: https://journal-vniispk.ru/1607-6729/article/view/213071
DOI: https://doi.org/10.1134/S1607672919050016
ID: 213071

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Abstract

The interaction of the GAF protein with the promoters of neuron-specific genes during activation and repression of transcription was studied. We showed that, while the Su(Hw) protein remains stably associated with the promoters of these genes at different transcriptional state, the GAF protein level is significantly higher when transcription is activated.