Email this article New Positive Allosteric Modulator of AMPA Receptors: in vitro and in vivo Studies
- Authors: Grigoriev V.V.1, Lavrov M.I.1,2, Zamoyski V.L.1, Garibova T.L.3, Palyulin V.A.1,2, Bachurin S.O.1
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Affiliations:
- Institute of Physiologically Active Compounds of the Russian Academy of Sciences
- Faculty of Chemistry, Moscow State University
- Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences
- Issue: Vol 488, No 1 (2019)
- Pages: 304-306
- Section: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/213075
- DOI: https://doi.org/10.1134/S160767291905003X
- ID: 213075
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Abstract
A new derivative of 3,7-diazabicyclo[3.3.1]nonane, which showed a high activity as a positive allosteric modulator of AMPA receptors of the CNS, was studied in electrophysiological experiments. At doses of 0.01 mg/kg, this compound significantly improved the memory of experimental animals disturbed by maximal electric shock. The results indicate that this compound is a promising candidate for preclinical trials and clinical studies as a drug for treatment of a number of psychoneurological diseases.
About the authors
V. V. Grigoriev
Institute of Physiologically Active Compounds of the Russian Academy of Sciences
Email: vzam@yandex.ru
Russian Federation, Chernogolovka, Moscow Region, 142432
M. I. Lavrov
Institute of Physiologically Active Compounds of the Russian Academy of Sciences; Faculty of Chemistry, Moscow State University
Email: vzam@yandex.ru
Russian Federation, Chernogolovka, Moscow Region, 142432; Moscow, 119991
V. L. Zamoyski
Institute of Physiologically Active Compounds of the Russian Academy of Sciences
Author for correspondence.
Email: vzam@yandex.ru
Russian Federation, Chernogolovka, Moscow Region, 142432
T. L. Garibova
Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences
Email: vzam@yandex.ru
Russian Federation, Moscow, 125315
V. A. Palyulin
Institute of Physiologically Active Compounds of the Russian Academy of Sciences; Faculty of Chemistry, Moscow State University
Email: vzam@yandex.ru
Russian Federation, Chernogolovka, Moscow Region, 142432; Moscow, 119991
S. O. Bachurin
Institute of Physiologically Active Compounds of the Russian Academy of Sciences
Email: vzam@yandex.ru
Russian Federation, Chernogolovka, Moscow Region, 142432
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