Email this article Sigma-1 Receptor Agonist Amitriptyline Inhibits Store-Dependent Ca2+ Entry in Macrophages
- Authors: Krutetskaya Z.I.1, Milenina L.S.1, Antonov V.G.1, Nozdrachev A.D.1,2
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Affiliations:
- St. Petersburg State University
- Institute of Physiology, Russian Academy of Sciences
- Issue: Vol 488, No 1 (2019)
- Pages: 307-310
- Section: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/213077
- DOI: https://doi.org/10.1134/S1607672919050041
- ID: 213077
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Abstract
Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor agonist–tricyclic antidepressant amitriptyline—significantly inhibits store-dependent Ca2+ entry, induced by endoplasmic Ca2+-ATPase inhibitors thapsigargin and cyclopiazonic acid, in rat peritoneal macrophages. The results suggest a possible involvement of sigma-1 receptors in the regulation of store-dependent Ca2+ entry in macrophages.
About the authors
Z. I. Krutetskaya
St. Petersburg State University
Author for correspondence.
Email: z.krutetskaya@spbu.ru
Russian Federation, St. Petersburg
L. S. Milenina
St. Petersburg State University
Email: a.d.nozdrachev@mail.ru
Russian Federation, St. Petersburg
V. G. Antonov
St. Petersburg State University
Email: a.d.nozdrachev@mail.ru
Russian Federation, St. Petersburg
A. D. Nozdrachev
St. Petersburg State University; Institute of Physiology, Russian Academy of Sciences
Author for correspondence.
Email: a.d.nozdrachev@mail.ru
Russian Federation, St. Petersburg;
St. Petersburg
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