Email this article Potassium Salt of Fullerenylpenta-N-Dihydroxytyrosine Effects on Type 2 Diabetes Mellitus Therapeutic Targets
- Authors: Soldatova Y.V.1,2, Kotelnikova R.A.1, Zhilenkov A.V.1, Faingold I.I.1,2, Troshin P.A.1,3, Kozlova M.A.2, Areshidze D.A.1,2, Aldoshin S.M.1
-
Affiliations:
- Institute of Problems of Chemical Physics, Russian Academy of Sciences
- Moscow Region State University
- Skolkovo Institute of Science and Technology
- Issue: Vol 488, No 1 (2019)
- Pages: 320-323
- Section: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/213087
- DOI: https://doi.org/10.1134/S1607672919050089
- ID: 213087
Cite item
Open Access
Access granted
Subscription Access
Abstract
It was shown for the first time that pentaamino acid derivative of fullerene C60 (potassium salt of fullerenylpenta-N-dihydroxytyrosine) affects three targets of type 2 diabetes mellitus. It competitively inhibits the enzymes aldose reductase and sorbitol dehydrogenase and also has an antiglycation effect on bovine serum albumin. The inhibition constants for these enzymes were calculated.
About the authors
Yu. V. Soldatova
Institute of Problems of Chemical Physics, Russian Academy of Sciences; Moscow Region State University
Author for correspondence.
Email: soldatovayv@gmail.com
Russian Federation, Chernogolovka, Moscow oblast, 142432; Moscow
R. A. Kotelnikova
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: soldatovayv@gmail.com
Russian Federation, Chernogolovka, Moscow oblast, 142432
A. V. Zhilenkov
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: soldatovayv@gmail.com
Russian Federation, Chernogolovka, Moscow oblast, 142432
I. I. Faingold
Institute of Problems of Chemical Physics, Russian Academy of Sciences; Moscow Region State University
Email: soldatovayv@gmail.com
Russian Federation, Chernogolovka, Moscow oblast, 142432; Moscow
P. A. Troshin
Institute of Problems of Chemical Physics, Russian Academy of Sciences; Skolkovo Institute of Science and Technology
Email: soldatovayv@gmail.com
Russian Federation, Chernogolovka, Moscow oblast, 142432; Moscow, 143025
M. A. Kozlova
Moscow Region State University
Email: soldatovayv@gmail.com
Russian Federation, Moscow
D. A. Areshidze
Institute of Problems of Chemical Physics, Russian Academy of Sciences; Moscow Region State University
Email: soldatovayv@gmail.com
Russian Federation, Chernogolovka, Moscow oblast, 142432; Moscow
S. M. Aldoshin
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: soldatovayv@gmail.com
Russian Federation, Chernogolovka, Moscow oblast, 142432
Supplementary files
