Email this article Dimeric Disintegrins from the Steppe Viper V. ursinii Venom
- Authors: Kryukova E.V.1, Potapenko A.S.1, Andreeva T.V.1, Ivanov I.A.1, Ryabinin V.V.1, Ziganshin R.H.1, Starkov V.G.1, Ayvazyan N.M.2, Tsetlin V.I.1, Utkin Y.N.1
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Affiliations:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Orbeli Institute of Physiology, National Academy of Sciences of the Republic of Armenia
- Issue: Vol 488, No 1 (2019)
- Pages: 338-341
- Section: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/213095
- DOI: https://doi.org/10.1134/S1607672919050132
- ID: 213095
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Abstract
Four dimeric disintegrins were isolated from the venom of the steppe viper V. ursinii using liquid chromatography. Disintegrins prevented adhesion of MCF7 cells to fibronectin, which indicates their interaction with integrin receptors of the αVβ1 type. According to mass spectrometry data, the molar masses of disintegrins are about 14 kDa. The method of peptide mapping established the structure of a new heterodimeric disintegrin weighing 13 995.5 Da and shows that it belongs to the class of RGD/KGD-containing disintegrins.
About the authors
E. V. Kryukova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Author for correspondence.
Email: evkr@mail.ru
Russian Federation, Moscow, 117997
A. S. Potapenko
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: evkr@mail.ru
Russian Federation, Moscow, 117997
T. V. Andreeva
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: evkr@mail.ru
Russian Federation, Moscow, 117997
I. A. Ivanov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: evkr@mail.ru
Russian Federation, Moscow, 117997
V. V. Ryabinin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: evkr@mail.ru
Russian Federation, Moscow, 117997
R. H. Ziganshin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: evkr@mail.ru
Russian Federation, Moscow, 117997
V. G. Starkov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: evkr@mail.ru
Russian Federation, Moscow, 117997
N. M. Ayvazyan
Orbeli Institute of Physiology, National Academy of Sciences of the Republic of Armenia
Email: evkr@mail.ru
Armenia, Yerevan, 0019
V. I. Tsetlin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: evkr@mail.ru
Russian Federation, Moscow, 117997
Yu. N. Utkin
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: evkr@mail.ru
Russian Federation, Moscow, 117997
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