Email this article Antioxidant Activity of Tetranitrosyl Iron Complex with Thiosulfate Ligands and Its Effect on Catalytic Activity of Mitochondrial Enzymes In vitro
- Authors: Faingold I.I.1,2, Kotelnikova R.A.1, Smolina A.V.1, Poletaeva D.A.1, Soldatova Y.V.1,2, Pokidova O.V.1, Sadkov A.P.1, Sanina N.A.1,2,3, Aldoshin S.M.1,3
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Affiliations:
- Institute of Problems of Chemical Physics, Russian Academy of Sciences
- Medicinal Chemistry Research and Education Center, Moscow Region State University
- Moscow State University
- Issue: Vol 488, No 1 (2019)
- Pages: 342-345
- Section: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/213097
- DOI: https://doi.org/10.1134/S1607672919050120
- ID: 213097
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Abstract
The antioxidant and antiradical properties of the tetra nitrosyl iron complex with thiosulfate ligands (TNIC) were studied in vitro in mouse brain homogenates. It was found for the first time that TNIC is an effective antioxidant. The effect of TNIC on the catalytic activity of mitochondrial enzymes cytochrome c oxidase and monoamine oxidase A was studied. It was shown for the first time that TNIC is an inhibitor of the catalytic activity of cytochrome c oxidase and monoamine oxidase A in animal brain mitochondria in vitro.
About the authors
I. I. Faingold
Institute of Problems of Chemical Physics, Russian Academy of Sciences; Medicinal Chemistry Research and Education Center, Moscow Region State University
Author for correspondence.
Email: ifaingold@mail.ru
Russian Federation, Chernogolovka, Moscow oblast; Mytischchi, Moscow oblast
R. A. Kotelnikova
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: ifaingold@mail.ru
Russian Federation, Chernogolovka, Moscow oblast
A. V. Smolina
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: ifaingold@mail.ru
Russian Federation, Chernogolovka, Moscow oblast
D. A. Poletaeva
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: ifaingold@mail.ru
Russian Federation, Chernogolovka, Moscow oblast
Yu. V. Soldatova
Institute of Problems of Chemical Physics, Russian Academy of Sciences; Medicinal Chemistry Research and Education Center, Moscow Region State University
Email: ifaingold@mail.ru
Russian Federation, Chernogolovka, Moscow oblast; Mytischchi, Moscow oblast
O. V. Pokidova
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: ifaingold@mail.ru
Russian Federation, Chernogolovka, Moscow oblast
A. P. Sadkov
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: ifaingold@mail.ru
Russian Federation, Chernogolovka, Moscow oblast
N. A. Sanina
Institute of Problems of Chemical Physics, Russian Academy of Sciences; Medicinal Chemistry Research and Education Center, Moscow Region State University; Moscow State University
Email: ifaingold@mail.ru
Russian Federation, Chernogolovka, Moscow oblast; Mytischchi, Moscow oblast; Moscow
S. M. Aldoshin
Institute of Problems of Chemical Physics, Russian Academy of Sciences; Moscow State University
Email: ifaingold@mail.ru
Russian Federation, Chernogolovka, Moscow oblast; Moscow
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