Email this article Histone Tails Promote PARP1-Dependent Structural Rearrangements in Nucleosomes
- Authors: Maluchenko N.V.1, Sultanov D.S.2, Kotova E.Y.2, Kirpichnikov M.P.1,3, Studitsky V.M.1,2, Feofanov A.V.1,3
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Affiliations:
- Moscow State University
- Fox Chase Cancer Center
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Issue: Vol 489, No 1 (2019)
- Pages: 377-379
- Section: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/213116
- DOI: https://doi.org/10.1134/S1607672919060061
- ID: 213116
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Abstract
PARP 1 alters the wrapping of nucleosomal DNA on the histone octamer, thereby modulating the accessibility of different genome sites to nuclear protein factors. Here, we show that non-structured histone tails are involved in the PARP1-induced structural rearrangements in nucleosomes, facilitate and stabilize them, but do not affect the enzymatic activity of PARP1.
About the authors
N. V. Maluchenko
Moscow State University
Author for correspondence.
Email: mal_nat@mail.ru
Russian Federation, Moscow, 119234
D. S. Sultanov
Fox Chase Cancer Center
Email: mal_nat@mail.ru
United States, Philadelphia
E. Yu. Kotova
Fox Chase Cancer Center
Email: mal_nat@mail.ru
United States, Philadelphia
M. P. Kirpichnikov
Moscow State University; Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: mal_nat@mail.ru
Russian Federation, Moscow, 119234; Moscow, 117997
V. M. Studitsky
Moscow State University; Fox Chase Cancer Center
Email: mal_nat@mail.ru
Russian Federation, Moscow, 119234; Philadelphia
A. V. Feofanov
Moscow State University; Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: mal_nat@mail.ru
Russian Federation, Moscow, 119234; Moscow, 117997
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