Email this article Recombinant Analogue of the Human Protein SLURP-1 Inhibits the Growth of Multicellular Spheroids Reconstructed from Carcinoma Cells
- Authors: Bychkov M.L.1, Shulepko M.A.1, Shlepova O.V.1,2, Lyukmanova E.N.1,2, Kirpichnikov M.P.1,3
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Affiliations:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
- Moscow Institute of Physics and Technology (National Research University)
- Faculty of Biology, Moscow State University
- Issue: Vol 489, No 1 (2019)
- Pages: 392-395
- Section: Biochemistry, Biophysics, and Molecular Biology
- URL: https://journal-vniispk.ru/1607-6729/article/view/213124
- DOI: https://doi.org/10.1134/S1607672919060103
- ID: 213124
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Abstract
In the present study we showed that the recombinant analogue of the SLURP-1 protein effectively inhibits the growth of a 3D model of tumors—multicellular spheroids reconstructed from human epidermoid carcinoma A431 cells and human lung adenocarcinoma A549 cells. The combined application of rSLURP-1 with gefitinib (inhibitor of epidermal growth factor receptor (EGFR)) leads to the synergistic antiproliferative effect on spheroids from A431 cells. The results obtained suggest the possibility for design of first-in-class anticancer drugs based on recombinant SLURP-1.
About the authors
M. L. Bychkov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Email: ekaterina-lyukmanova@yandex.ru
Russian Federation, Moscow, 117997
M. A. Shulepko
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Author for correspondence.
Email: mikhailshulepko@gmail.com
Russian Federation, Moscow, 117997
O. V. Shlepova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences; Moscow Institute of Physics and Technology (National Research University)
Email: ekaterina-lyukmanova@yandex.ru
Russian Federation, Moscow, 117997; Dolgoprudnyi, Moscow oblast, 141701
E. N. Lyukmanova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences; Moscow Institute of Physics and Technology (National Research University)
Author for correspondence.
Email: ekaterina-lyukmanova@yandex.ru
Russian Federation, Moscow, 117997; Dolgoprudnyi, Moscow oblast, 141701
M. P. Kirpichnikov
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences; Faculty of Biology, Moscow State University
Email: ekaterina-lyukmanova@yandex.ru
Russian Federation, Moscow, 117997; Moscow, 119234
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