电邮这篇文章 IMMUNOLOGICAL MECHANISMS OF ANTI-INFLAMMATORY ACTION OF MODIFIED YELLOW CLAY IN THE EXPERIMENT
- 作者: Sagradyan Gayane Valerievna G.1,2, Abramtsova A.V.3
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隶属关系:
- 1Federal State Budgetary Institution "North Caucasian Federal Scientific and Clinical Center of Federal Medical and Biological Agency"
- 2Рyatigorsk Medical Pharmaceutical Institute – branch of Volgograd State Medical University
- Federal State Budgetary Institution "North Caucasian Federal Scientific and Clinical Center of the Federal Medical and Biological Agency"
- 期: 卷 21, 编号 2 (2022)
- 页面: 107-113
- 栏目: Original studies
- URL: https://journal-vniispk.ru/1681-3456/article/view/109297
- ID: 109297
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详细
BACKGROUND. One of the tasks of experimental balneology is the study of little-studied natural sources and the production of modified balneological remedies used in diseases of the musculoskeletal system.
AIMS: is to evaluate immunological mechanisms of anti-inflammatory action of external balneological medicine based on natural clays to study their therapeutic effectiveness in diseases of musculoskeletal system in the adjuvant arthritis model.
MATERIAL AND METHODS: An experimental study was conducted with the participation of 79 laboratory animals (male rats, Wistar line) distributed by simple sampling into 5 groups: in the control group 1 (n = 15) there were healthy animals (intact); in the 2nd group (n = 13) the animals had adjuvant arthritis (AA) without exposure; the 3rd group (n = 17) had an AA model and Tambukan dirt; in the 4th group (n = 17) there was model AA and a course of yellow clay, the 5th group (n = 17) had model AA and a course of modified clay. The anti-inflammatory effects of native and modified external balneological medicine were examined by evaluating the response of immune-competent cells of peripheral blood in reproducing chronic inflammation in AA model.
RESULTS: The conducted studies have shown that the external use of modified yellow clay in the form of balneological medicine “Glinofir” is comparable to the effect of Tambukan dirt. According to the immune marker analysis there was a significant change in population lymphocyte structure in peripheral blood as a result of AA modeling, namely, the number of B lymphocytes increased (2.5 times; p < 0.02) with simultaneous reduction of total T-lymphocytes (2.5 times; p < 0.05); the level of circulating immune complexes showed a tendency to increase with the animals of the group with AA model without treatment (59.8 ± 4.18 units in AA and 52.4 ± 3.44 units with healthy animals; p = 0.1).
CONCLUSION: According to the results of the experimental studies, “Glinofir” which has immune-modulatory and anti-inflammatory effects can be recommended for subsequent introduction into clinical practice as the treatment and medical rehabilitation of patients with diseases of musculoskeletal system.
作者简介
Gayane Sagradyan Gayane Valerievna
1Federal State Budgetary Institution "North Caucasian Federal Scientific and Clinical Center of Federal Medical and Biological Agency"; 2Рyatigorsk Medical Pharmaceutical Institute – branch of Volgograd State Medical University
Email: zamoms@skfmba.ru
ORCID iD: 0000-0001-7970-1958
SPIN 代码: 9629-5773
Scopus 作者 ID: 57204624456
Кандидат медицинских наук,старший научный сотрудник ОИМДФФ ПНИИК ФФГБУ СКФНКЦ ФМБА России в г. Пятигорске
俄罗斯联邦, 357500, Pyatigorsk, Kirov Avenue, 30 357500, Pyatigorsk, Kalinin Avenue,11Anna Abramtsova
Federal State Budgetary Institution "North Caucasian Federal Scientific and Clinical Center of the Federal Medical and Biological Agency"
编辑信件的主要联系方式.
Email: a.v.abramtsova@skfmba.ru
ORCID iD: 0000-0001-7435-6286
SPIN 代码: 9608-8004
Scopus 作者 ID: 57194732233
Candidate of Medical Sciences, Senior Researcher 俄罗斯联邦, 357500, Pyatigorsk, Kirov Avenue, 30
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