二型糖尿病患者在激光照射和经皮电泳铜钙联合治疗法下的丙酮酸-乳酸反应伴牙周炎
- 作者: Kylikova N.G.1,2, Chkheidze T.2, Tkachenko A.S.2
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隶属关系:
- I.M. Sechenov First Moscow State Medical University
- Peoples' Friendship University of Russia named after Patrice Lumumba
- 期: 卷 24, 编号 1 (2025)
- 页面: 48-55
- 栏目: Original studies
- URL: https://journal-vniispk.ru/1681-3456/article/view/286138
- DOI: https://doi.org/10.17816/rjpbr646519
- ID: 286138
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详细
背景。现代医学中的一个紧迫问题是糖尿病及其相关的并发症,包括牙科并发症。口腔炎症过程与全身状况之间的潜在关系已讨论多年,因为糖尿病会改变重要器官系统的代谢成分。
研究目的。 通过使用经皮(通过牙髓管进行的铜钙经皮电泳)电泳铜钙和激光照射联合治疗,改善二型糖尿病患者的牙科治疗效果,特别是针对牙周病和牙周炎患者。
材料与方法。进行了一项随机开放临床研究,研究对象为123名患有二型糖尿病并确诊为牙周病的患者。所有参与者签署知情同意书后,进行了口腔检查,并采用了额外的放射学诊断方法来确认牙周病和牙周炎的病理变化。为了评估牙周和牙周韧带组织的酸碱平衡,使用Lactat/Peruvat检测系统(LOX-PAP,Biocom,德国)测量血液中的丙酮酸和乳酸水平,并在治疗前后监测血糖水平(使用Express-Satellite-PKG-0.3方法)。
结果。在75名(61.0%)参与者中,基线乳酸水平出现显著变化,乳酸值比生理标准高出2.9倍(p <0.05),丙酮酸水平则下降33.6%(p <0.01)。联合治疗后,丙酮酸水平上升,乳酸水平下降,乳酸与丙酮酸的生理比例从54.8 [51.7; 57.9]下降至31.6 [30.7; 32.6]单位(p <0.05),表明组织内缺氧和酸碱失衡现象得到了纠正。
作者简介
Natalia G. Kylikova
I.M. Sechenov First Moscow State Medical University; Peoples' Friendship University of Russia named after Patrice Lumumba
编辑信件的主要联系方式.
Email: kulikovang777@mail.ru
ORCID iD: 0009-0007-0374-6763
SPIN 代码: 6613-1164
MD, Dr. Sci. (Medicine), Professor
俄罗斯联邦, Moscow; 6 Miklukho-Maklaya st, Moscow, 117198Tinatin Chkheidze
Peoples' Friendship University of Russia named after Patrice Lumumba
Email: tinatin@mail.ru
ORCID iD: 0000-0003-1797-1324
SPIN 代码: 4134-4069
俄罗斯联邦, 6 Miklukho-Maklaya st, Moscow, 117198
Albina S. Tkachenko
Peoples' Friendship University of Russia named after Patrice Lumumba
Email: rocstar-fo@to.ru
ORCID iD: 0000-0001-8506-8562
SPIN 代码: 6126-1475
MD, Cand. Sci. (Medicine), Assistant Professor
俄罗斯联邦, 6 Miklukho-Maklaya st, Moscow, 117198参考
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