Immunoprotective therapy of suppression of humoral immune response, pain induced (search for narcotic analgesics with immunoprotective activity)

V. N. Aleksandrov; Александров В. Н.; A. A. Kondratenko; Кондратенко А. А.; E. V. Mikhailova; Михайлова Е. В.; S. V. Kromsky; Кромский С. В.; V. S. Sidorin; Сидорин В. С.; L. P. Sigareva; Сигарева Л. П.; M. I. Eliseeva; Елисеева М. И.; V. A. Gorichny; Горичный В. А.; N. V. Pak; Пак Н. В.; P. A. Slizhov; Слижов П. А.

doi:10.17816/brmma50057

Immunoprotective therapy of suppression of humoral immune response, pain induced (search for narcotic analgesics with immunoprotective activity)

Authors: Aleksandrov V.N.¹^,2, Kondratenko A.A.³, Mikhailova E.V.², Kromsky S.V.², Sidorin V.S.³, Sigareva L.P.², Eliseeva M.I.³, Gorichny V.A.³, Pak N.V.³, Slizhov P.A.¹^,4
Affiliations:
1. Military Medical Academy. CM. Kirov
2. Saint Petersburg State Pediatric Medical University
3. Military Medical Academy. S. M. Kirov
4. Russian State Pedagogical University. A.I. Herzen
Issue: Vol 22, No 2 (2020)
Pages: 122-124
Section: Articles
URL: https://journal-vniispk.ru/1682-7392/article/view/50057
DOI: https://doi.org/10.17816/brmma50057
ID: 50057

Cite item

Full Text

Abstract
Full Text
About the authors
References
Supplementary files
Statistics

Abstract

Problematic issues of prevention of humoral immune response suppression induced by pain in conditions of the experimental model of severe mechanical trauma are highlighted. It has been established that one of the pathogenetic factors of trauma depressing the humoral immune response is pain. Thus, drugs inhibiting intra-central transmission of afferent impulse, and, in particular, narcotic analgesics, may be considered as drugs with immunoprotective activity. Evaluation of the immunoprotective activity of five narcotic analgesics administered immediately after trauma to immunized mice in the first 24 hours of post-traumatic period showed the presence of the estimated effect in morphine hydrochloride, fentanyl and pifurben. By 106 splenocytes of mice received these preparations and immunized on the first day after the trauma, reliably more antibodies forming cells are formed in mice in comparison with their number in animals received after the trauma as narcotic analgesics intermediol and dipidolor. Thus, morphine hydrochloride, fentanyl and pifurben, i.e. drug analgesics with immunoprotective activity, should be considered as the preferred drugs in the group of narcotic analgesics in emergency care for patients with severe trauma. The use of narcotic analgesics with immunoprotective properties should be considered as one of the measures in the complex of measures aimed at the prevention of post-traumatic immunodeficiency and infection in an immunocompromised host. Infections are difficult to diagnose and often with an unfavorable outcome.

Keywords

injur y, shock, pain, secondar y immune deficiency, infection, immune response, drug analgesic, immunoprotective activity, antibodies forming cells

Full Text

##article.viewOnOriginalSite##

References

Supplementary files

Supplementary Files

Action

1. JATS XML

Download

Username
Password
Remember me

Forgot password?	Register

Username
Password
Remember me

Forgot password?	Register

Immunoprotective therapy of suppression of humoral immune response, pain induced (search for narcotic analgesics with immunoprotective activity)

Full Text

Abstract

Keywords

Full Text

About the authors

References

Supplementary files