TRACE CONCENTRATIONS OF ORGANOCHLORINE COMPOUNDS IN BIOLOGICAL LIQUIDS OF THE RUSSIAN FAR EAST RESIDENTS


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The aim. The problem of accumulation of organochlorine compounds (OCPs) in the human body is relevant, because these substances have potential teratogenic, carcinogenic, hormonal, neurological and immunological properties. Thus, the purpose of the work is to identify trace organochlorine compounds (a-, ß-, y-hexachlorocyclohexane (HCH), dichlorodiphenyltrichloroethane (DDT), dichlorodiphenyldichloroethane, dichlorodiphenyldichlorethylene (DDE)) in the blood and urine of the residents of the south of the Russian Far East. Methods. The urine and blood of residents of the south of the Russian Far Eastern region were examined by gas chromatography-mass spectrometry to study the content of OCPs trace concentrations. Results: a- and y-isomers of hexachlorocyclohexane (HCH), dichlorodiphenyltrichloroethane (DDT), dichlorodiphenyldichlorethylene (DDE) were detected in the urine. Only ß-HCH in the blood was detected. Conclusions. The spectrum of basic OCPs in the urine indicates the possibility of its excretion by the body; however, the detection in the blood of only ß-HCH indicates a longer retention of the latter as the most stable isomer. A comparative evaluation of the obtained results with the data of other authors showed that the detected concentrations of cholesterol in the blood of residents of the Far East were lower than in typical agricultural countries and were found in no more than 30 % of the sample.

作者简介

V Tsygankov

Far Eastern Federal University

Email: tsygankov.vyu@dvfu.ru
SchooL of Biomedicine Vladivostok, Russia

M Yarygina

Far Eastern Federal University

SchooL of Biomedicine Vladivostok, Russia

O Lukyanova

Far Eastern Federal University; Pacific Research Fisheries Centre (TINRO-Centre)

School of Natural Sciences Vladivostok, Russia

M Boyarova

Far Eastern Federal University

SchooL of Biomedicine Vladivostok, Russia

N Erofeeva

Far Eastern Federal University

SchooL of Biomedicine Vladivostok, Russia

S Gamova

The Far Eastern District Medical Center of the Federal Medical Biological Agency (FEDMC FMBA of Russia)

Vladivostok, Russia

A Gumovskiy

Far Eastern Federal University

SchooL of Biomedicine Vladivostok, Russia

P Kiku

Far Eastern Federal University

SchooL of Biomedicine Vladivostok, Russia

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