农村青少年膳食中饱和与不饱和脂肪酸含量:与脂质过氧化过程的相关性
- 作者: Darenskaya M.A.1, Rychkova L.V.1, Astakhova T.A.1, Pogodina A.V.1, Dolgikh O.A.1, Klimkina Y.N.1, Yuzvak N.A.1, Kolesnikova L.I.1
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隶属关系:
- Scientific Centre for Family Health and Human Reproduction Problems
- 期: 卷 31, 编号 10 (2024)
- 页面: 768-779
- 栏目: ORIGINAL STUDY ARTICLES
- URL: https://journal-vniispk.ru/1728-0869/article/view/314553
- DOI: https://doi.org/10.17816/humeco643126
- EDN: https://elibrary.ru/RYSREI
- ID: 314553
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背景。均衡膳食是心血管疾病预防的关键因素之一。青少年膳食中充足的脂肪酸摄入,无疑是其抵御不良环境因素的一个重要条件。脂质过氧化反应与抗氧化防御反应的活性,有助于评估个体对不利因素的抵抗能力,并决定其适应性反应。生活在农村地区的青少年尚未被充分研究。
目的。明确农村青少年膳食中脂肪酸组成的特征,评估其“脂质过氧化–抗氧化防御”系统的相关指标,并分析二者之间的可能关联。
材料与方法。采用横断面研究方法,分析了Irkutsk州农村地区76名14–17岁青少年(38名男生、38名女生)的数据。通过24小时膳食回顾法评估实际摄入,并将其与能量和营养素生理需求标准进行对比。“脂质过氧化–抗氧化防御”系统指标通过分光光度法和荧光光度法测定。
结果。农村青少年膳食中饱和脂肪酸和单不饱和脂肪酸摄入较高,而Omega-3和Omega-6多不饱和脂肪酸摄入不足。检测到单不饱和脂肪酸(如肉豆蔻烯酸、棕榈油烯酸)和多不饱和脂肪酸(如α-亚麻酸、花生四烯酸、二十二碳六烯酸和二十碳五烯酸)的摄入水平偏低。在青少年血液中检测到脂质过氧化的终产物、α-生育酚和还原型谷胱甘肽水平升高,而初级产物、总抗氧化活性和视黄醇水平降低。相关性分析显示:酮二烯和共轭三烯与估算的油酸摄入量相关;TBA活性产物与花生四烯酸相关;总抗氧化活性与辛酸和月桂酸相关;超氧化物歧化酶活性与估算的二十二碳六烯酸摄入量相关;α-生育酚与二十二碳酸相关。发现氧化型谷胱甘肽与以下脂肪酸的估算水平之间存在多重正相关:辛酸、月桂酸、棕榈酸、硬脂酸、总单不饱和脂肪酸、棕榈油烯酸和油酸。
结论。膳食中饱和与不饱和脂肪酸的估算摄入量可用于识别农村青少年营养摄入的不足,并可能与系统性脂质过氧化过程的活性升高相关。
作者简介
Marina A. Darenskaya
Scientific Centre for Family Health and Human Reproduction Problems
编辑信件的主要联系方式.
Email: marina_darenskaya@inbox.ru
ORCID iD: 0000-0003-3255-2013
SPIN 代码: 3327-4213
Dr. Sci. (Biology), Professor of Russian Academy of Sciences
俄罗斯联邦, 16 Timiryasev st, Irkutsk, 664003Lyubov V. Rychkova
Scientific Centre for Family Health and Human Reproduction Problems
Email: rychkova.nc@gmail.com
ORCID iD: 0000-0003-2910-0737
SPIN 代码: 1369-6575
MD, Dr. Sci. (Medicine), Professor, Corresponding Member of Russian Academy of Sciences
俄罗斯联邦, 16 Timiryasev st, Irkutsk, 664003Tatyana A. Astakhova
Scientific Centre for Family Health and Human Reproduction Problems
Email: tatjana_astahova@mail.ru
ORCID iD: 0000-0003-1427-4734
SPIN 代码: 3596-8613
MD, Cand. Sci. (Medicine)
俄罗斯联邦, 16 Timiryasev st, Irkutsk, 664003Anna V. Pogodina
Scientific Centre for Family Health and Human Reproduction Problems
Email: pogodina_av@inbox.ru
ORCID iD: 0000-0001-8533-3119
SPIN 代码: 6059-0340
MD, Dr. Sci. (Medicine)
俄罗斯联邦, 16 Timiryasev st, Irkutsk, 664003Olga A. Dolgikh
Scientific Centre for Family Health and Human Reproduction Problems
Email: iphr@sbamsr.irk.ru
ORCID iD: 0000-0002-2850-9066
俄罗斯联邦, 16 Timiryasev st, Irkutsk, 664003
Yuliana N. Klimkina
Scientific Centre for Family Health and Human Reproduction Problems
Email: yuliana_29@mail.ru
SPIN 代码: 5075-8560
俄罗斯联邦, 16 Timiryasev st, Irkutsk, 664003
Natalya A. Yuzvak
Scientific Centre for Family Health and Human Reproduction Problems
Email: iuzvak.n@yandex.ru
ORCID iD: 0009-0007-9812-8836
SPIN 代码: 1340-4457
俄罗斯联邦, 16 Timiryasev st, Irkutsk, 664003
Lyubov I. Kolesnikova
Scientific Centre for Family Health and Human Reproduction Problems
Email: kolesnikova20121@mail.ru
ORCID iD: 0000-0003-3354-2992
SPIN 代码: 1584-0281
MD, Dr. Sci. (Medicine), Professor, Member of the Russian Academy of Sciences
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