Single nucleotide variants in interferon system genes in indigenous and non-indigenous residents of the Arkhangelsk region
- Authors: Krieger E.A.1, Samodova O.V.1, Bebyakova N.A.1, Kudryavtsev A.V.1, Ivanova L.V.1, Samoilikov R.V.2, Potapova M.B.2, Solntseva V.K.3, Meremianina E.A.2, Svitich O.A.2,3
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Affiliations:
- Northern State Medical University
- I. Mechnikov Research Institute of Vaccines and Sera
- Sechenov First Moscow State Medical University
- Issue: Vol 32, No 4 (2025)
- Pages: 267-279
- Section: ORIGINAL STUDY ARTICLES
- URL: https://journal-vniispk.ru/1728-0869/article/view/314588
- DOI: https://doi.org/10.17816/humeco678036
- EDN: https://elibrary.ru/IIOVJH
- ID: 314588
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Abstract
Background: In addition to climatic and social factors, individual susceptibility to infectious diseases among residents of the North is influenced by nucleotide sequence variants in interferon system genes. The protein products of these genes are involved in the immune response.
Aim: The study aimed to assess the prevalence of single nucleotide variants in interferon system genes (IFNAR1, IFNAR2, IFNGR1, IFNL4 (IL-28B)) in indigenous and non-indigenous residents of Arkhangelsk region.
METHODS: A cross-sectional study was conducted on a random sample of adults aged 43–74 years residing in Arkhangelsk (N=232; 36.6% male). The study protocol included participant interviews and molecular genetic analysis to determine alleles and genotypes of the following single nucleotide variants: rs2257167 in IFNAR1, rs2229207 in IFNAR2, rs1327474 in IFNGR1, rs12979860 and rs8099917 in IFNL4 (IL-28B). The observed genotype distributions in indigenous and non-indigenous groups were evaluated for compliance with Hardy–Weinberg equilibrium and compared between the groups.
Results: The study population included 86 indigenous and 146 non-indigenous residents of Arkhangelsk region. Among non-indigenous residents, the genotype distributions of the variants rs2229207 (IFNAR2) and rs12979860 (IFNL4 (IL-28B)) deviated from Hardy–Weinberg equilibrium due to an excess of heterozygotes. At the same time, for the rs1327474 (IFNGR1), the number of heterozygotes was lower than expected. The frequency of the C allele of rs2229207 (IFNAR2), associated with severe viral infections, was higher in the Arkhangelsk region population than in European and global populations. The homozygous CC genotype of rs2229207 (IFNAR2) was significantly less common in indigenous residents of the Arkhangelsk region (2.6%) than in non-indigenous residents (11.2%). A higher frequency of the heterozygous CT genotype of rs1327474 (IFNGR1) was observed in the non-indigenous residents.
Conclusion: This study identified specific features of the genetic structure of the adult population of the Arkhangelsk region, shaped by migration from other regions to the North. These findings reflect a higher prevalence of genetic susceptibility markers for viral infections among the non-indigenous population of the European North.
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##article.viewOnOriginalSite##About the authors
Ekaterina A. Krieger
Northern State Medical University
Author for correspondence.
Email: kate-krieger@mail.ru
ORCID iD: 0000-0001-5179-5737
SPIN-code: 2686-7226
MD, Cand. Sci. (Medicine), Ph.D, Associate Professor
Russian Federation, 51 Troitskiy ave, Arkhangelsk, 163069Olga V. Samodova
Northern State Medical University
Email: ovsamodova@mail.ru
ORCID iD: 0000-0002-6730-6843
SPIN-code: 9113-4496
Dr. Sci. (Medicine), Professor
Russian Federation, 51 Troitskiy ave, Arkhangelsk, 163069Natalya A. Bebyakova
Northern State Medical University
Email: nbebyakova@mail.ru
ORCID iD: 0000-0002-9346-1898
SPIN-code: 6326-5523
Dr. Sci. (Biology), Professor
Russian Federation, 51 Troitskiy ave, Arkhangelsk, 163069Alexander V. Kudryavtsev
Northern State Medical University
Email: alex.v.kudryavtsev@yandex.ru
ORCID iD: 0000-0001-8902-8947
SPIN-code: 9296-2930
Ph.D.
Russian Federation, 51 Troitskiy ave, Arkhangelsk, 163069Liudmila V. Ivanova
Northern State Medical University
Email: ivanova.liudmila.v@yandex.ru
ORCID iD: 0000-0001-7682-4821
SPIN-code: 3609-1254
Russian Federation, 51 Troitskiy ave, Arkhangelsk, 163069
Roman V. Samoilikov
I. Mechnikov Research Institute of Vaccines and Sera
Email: roma_sam78@mail.ru
ORCID iD: 0000-0001-6405-1390
SPIN-code: 3373-1321
Russian Federation, Moscow
Mariia B. Potapova
I. Mechnikov Research Institute of Vaccines and Sera
Email: ptpv.msh@gmail.com
ORCID iD: 0000-0001-9647-1322
SPIN-code: 1066-6146
Russian Federation, Moscow
Viktoriia K. Solntseva
Sechenov First Moscow State Medical University
Email: solntseva_v_k@staff.sechenov.ru
ORCID iD: 0000-0003-3783-9232
MD, Cand. Sci. (Medicine), Associate Professor
Russian Federation, MoscowEkaterina A. Meremianina
I. Mechnikov Research Institute of Vaccines and Sera
Email: ekaterina@meremianina.ru
ORCID iD: 0000-0003-4334-1473
SPIN-code: 9721-4839
MD, Cand. Sci. (Medicine)
Russian Federation, MoscowOxana A. Svitich
I. Mechnikov Research Institute of Vaccines and Sera; Sechenov First Moscow State Medical University
Email: svitichoa@yandex.ru
ORCID iD: 0000-0003-1757-8389
SPIN-code: 8802-5569
MD, Dr. Sci (Medicine), Academician of Russian Academy of Science
Russian Federation, Moscow; MoscowReferences
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