Email this article LIPID PEROXIDATION AND ANTIOXIDANT DEFENSE SYSTEM IN MENOPAUSAL WOMEN OF DIFFERENT ETHNIC GROUPS
- Authors: Semenova N.V.1, Madaeva I.M.1, Darenskaya M.A.1, Kolesnikova L.I.1
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Affiliations:
- Scientific Centre for Family Health and Human Reproduction Problems
- Issue: Vol 26, No 6 (2019)
- Pages: 30-38
- Section: Articles
- URL: https://journal-vniispk.ru/1728-0869/article/view/35031
- DOI: https://doi.org/10.33396/1728-0869-2019-6-30-38
- ID: 35031
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Abstract
Aim: Сomparative assessment of lipid peroxidation - antioxidant defense parameters in Caucasian and Asian women in peri- and postmenopause. Methods: Altogether, 146 women of Caucasian (Russians (n = 82)) and Asian (Buryats (n = 64)) origins participated in the prospective non-randomized study. Each ethnic group was divided into three subgroups - women of reproductive age, perimeno-pause, postmenopause according to the gynecological status. The lipid peroxidation - antioxidant defense parameters were determined by spectrophotometric methods. Non-parametric tests were used for comparisons of the three independent groups. Results: in Russian perimenopausal women compared to women of reproductive age, an increase of lipid peroxidation substrates by 1.27 times (p = 0.032), active products of thiobarbituric acid (TBARS) by 1.25 times (p = 0.041), oxidized glutathione by 1.33 times (p = 0.021) levels and decrease of ketodienes and conjugated trienes (KD-CT) by 1.85 times (p < 0.001), retinol by 1.32 times (p = 0.043) levels, followed by an increase of KD-CT levels by 2 times (p < 0.001) and decrease of TBARS by 1.28 times (p = 0.042), а-tocopherol by 1.37 times (p = 0.001), retinol by 1.14 times (p = 0.019), GSSG by 1.16 times (p = 0.044) levels in postmenopausal women. In perimenopausal representatives of the Buryat ethnos compared with women of reproductive age, an decrease of lipid peroxidation substrates by 1.66 times (p < 0.001), conjugated dienes (CD) by 2.41 times (p < 0.001), KD-CT by 1.53 times (p = 0.045), а-tocopherol by 1.64 times (p < 0.001), retinol by 1.20 times (p = 0.024) levels, followed by an increase of lipid peroxidation substrates by 1.31 times (p = 0.028), CD by 1.53 times (p = 0.008), KD-CT by 1.32 times (p = 0.032) levels in postmenopausal women. Conclusions: Our results suggest that oxidative stress in menopause is more pronounced in Caucasian than in Asian women.
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##article.viewOnOriginalSite##About the authors
N. V. Semenova
Scientific Centre for Family Health and Human Reproduction Problems
Email: natkor_84@mail.ru
доктор биологических наук, старший научный сотрудник лаборатории патофизиологии
I. M. Madaeva
Scientific Centre for Family Health and Human Reproduction Problems
M. A. Darenskaya
Scientific Centre for Family Health and Human Reproduction Problems
L. I. Kolesnikova
Scientific Centre for Family Health and Human Reproduction Problems
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