The effect of tuberculosis on the course of lung carcinoma in the experiment
- Авторлар: Kudriashov G.G.1, Nefedov A.O.1, Tochilnikov G.V.2, Zmitrichenko Y.G.2, Krylova Y.S.1, Dogonadze M.Z.1, Zabolotnyh N.V.1, Gavrilov P.V.1, Azarov A.A.1, Davydenkova E.A.1, Vinogradova T.I.1, Yablonskiy P.K.1
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Мекемелер:
- Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation
- N.N. Petrov National Medicine Research Center of oncology
- Шығарылым: Том 21, № 1 (2023)
- Беттер: 43-49
- Бөлім: Original research
- URL: https://journal-vniispk.ru/1728-2918/article/view/143914
- DOI: https://doi.org/10.29296/24999490-2023-01-06
- ID: 143914
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Тек жазылушылар үшін
Аннотация
Introduction. One of the problems of modern medicine is the low efficiency of treatment of patients with a coexistence of lung cancer and active tuberculosis. Optimal treatment regimens for coexistence pathology have not been developed at present. In recent years, fundamental research aimed to studying the unexplained mechanisms of the occurrence and course of coexistence pathology.
The aim of the study was to investigate the peculiarities of the effect of tuberculosis with different drug resistance on the course of lung carcinoma in an experiment.
Methods. The study was performed on 72 mice of the C57BL/6 line at the age of two months. To achieve the goal, three groups of laboratory animals were formed: Group 1 – mice infected with the reference strain Mycobacterium tuberculosis H37Rv, which underwent isolated transplantation of Lewis lung epidermoid carcinoma (n=24); Group 2 – mice infected with the clinical strain Mycobacterium tuberculosis 5582 with multidrug resistance, which underwent isolated transplantation of epidermoid lung carcinoma Lewis (n=24); Group 3 – uninfected mice that underwent isolated transplantation of Lewis lung epidermoid carcinoma (n=24). Clinical, radiological, morphological and bacteriological methods were used to compare the studied groups of animals. Statistical analysis was performed using the SPSS Statistica v23 software package.
Results. In group 3, there was significantly (p<0.01) more intensive weight gain by mice due to rapid tumor growth, in contrast to groups 1 and 2. Histological signs of pulmonary tuberculosis were detected in all infected mice (groups 1 and 2) in the form of productive pneumonia. The greatest increase in the lung mass coefficient was detected in group 2 compared to groups 1 and 3, which is explained by the subtotal spread of productive specific pneumonia when infected with a clinical drug-resistant strain of M. Tuberculosis. The lowest dynamics of lung mass coefficient was recorded in group 3. The worst survival was observed in group 2 (median was 22 days, 95% CI=21.4–22.6). Survival in groups 1 and 3 did not significantly differ and was 28 days in both groups (95% CI=25.3–30.7 in group 1, 95% CI=26.0–30.0 for group 3).
Conclusion. An experimental study showed that tumor progression slows down in M. tuberculosis infected animals compared to the control group. The coexistence of lung carcinoma and drug-sensitive tuberculosis is accompanied by the best prognosis. The coexistence of Lewis lung carcinoma and drug-resistant tuberculosis is accompanied by a large volume of lung tissue involvement and worse survival.
Толық мәтін
##article.viewOnOriginalSite##Авторлар туралы
Grigorii Kudriashov
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation
Хат алмасуға жауапты Автор.
Email: dr.kudriashov.gg@yandex.com
ORCID iD: 0000-0002-2810-8852
Senior Research Associate, thoracic surgeon, Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation. MD, PhD.
Ресей, Ligovsky av., 2–4, St. Petersburg, 191036Andrey Nefedov
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation
Email: herurg78@mail.ru
ORCID iD: 0000-0001-6228-182X
Senior Research Associate, Head of the Department of Thoracic Oncology, Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation. MD, PhD.
Ресей, Ligovsky av., 2–4, St. Petersburg, 191036Grigorii Tochilnikov
N.N. Petrov National Medicine Research Center of oncology
Email: gr75@mail.ru
ORCID iD: 0000-0003-4232-8170
Head of the Scientific Laboratory of Cancer Chemoprophylaxis and Oncopharmacology. N.N. Petrov National Medicine Research Center of oncology. MD, PhD.
Ресей, Leningradskaya str., 68, village Pesochny, St. Petersburg, 197758Yuliya Zmitrichenko
N.N. Petrov National Medicine Research Center of oncology
Email: zmitrichenko@gmail.com
ORCID iD: 0000-0002-9137-9532
Junior Research Associate, Scientific Laboratory of Cancer Chemoprophylaxis and Oncopharmacology. N.N. Petrov National Medicine Research Center of oncology
Ресей, Leningradskaya str., 68, village Pesochny, St. Petersburg, 197758Yulia Krylova
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation
Email: emerald2008@mail.ru
ORCID iD: 0000-0002-8698-7904
Senior Research Associate, Center for Molecular Biomedicine, Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation. MD, PhD.
Ресей, Ligovsky av., 2–4, St. Petersburg, 191036Marine Dogonadze
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation
Email: marine-md@mail.ru
ORCID iD: 0000-0002-9161-466X
Senior Research Associate, Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation. MD, PhD.
Ресей, Ligovsky av., 2–4, St. Petersburg, 191036Natalia Zabolotnyh
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation
Email: info@spbniif.ru
ORCID iD: 0000-0002-2946-2415
Leading Research Associate, Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation. MD, PhD, Dr. Sci. (Med.).
Ресей, Ligovsky av., 2–4, St. Petersburg, 191036Pavel Gavrilov
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation
Email: spbniifrentgen@mail.ru
ORCID iD: 0000-0003-3251-4084
Leading Research Associate. Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation. MD, PhD.
Ресей, Ligovsky av., 2–4, St. Petersburg, 191036Artem Azarov
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation
Email: azardoc0@gmail.com
ORCID iD: 0000-0002-4898-5991
Postgraduate Student. Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation
Ресей, Ligovsky av., 2–4, St. Petersburg, 191036Ekaterina Davydenkova
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation
Email: sirenasudeki@yandex.ru
ORCID iD: 0000-0001-5336-0382
Trainee Research Associate. Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation.
Ресей, Ligovsky av., 2–4, St. Petersburg, 191036Tatiana Vinogradova
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation
Email: ti.vinogradova@spbniif.ru
ORCID iD: 0000-0002-5234-349X
Project Leader, Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation.
Ресей, Ligovsky av., 2–4, St. Petersburg, 191036Piotr Yablonskiy
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation
Email: glhirurgb2@mail.ru
ORCID iD: 0000-0003-4385-9643
Director Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation. MD, PhD, Dr. Sci. (Med.), professor.
Ресей, Ligovsky av., 2–4, St. Petersburg, 191036Әдебиет тізімі
- Ye M.F., Su S., Huang Z.H., Zou J.J., Su D.H., Chen X.H., Zeng L.F., Liao W.X., Huang H.Y., Zeng Y.Y., Cen W.C., Zhang X.L., Liao C.X., Zhang J., Zhang Y.B. Efficacy and safety of concurrent anti-tuberculosis treatment and chemotherapy in lung cancer patients with co-existent tuberculosis. Ann Transl Med. 2020; 8 (18): 1143. doi: 10.21037/atm-20-5964.
- Lee C.S., Shu C.C., Chen Y.C., Liao K.M., Ho C.H. Treatment Incompletion of Tuberculosis in Patients with Lung Cancer: the Occurrence and Prediction Factors. International Journal of Infectious Diseases: IJID: Official Publication of the International Society for Infectious Diseases. 2021; 113: 200–6.
- Крылова Ю.С., Кудряшов Г.Г., Нефедов А.О., Дохов М.А., Захарченко А.О., Яблонский П.К. Сигнальные молекулы опухолевой трансформации при туберкулезе. Молекулярная медицина. 2022; 20 (6): 12–15. https://doi.org/10.29296/24999490-2022-06-02 [Krylova Yu.S., Kudriashov G.G., Nefedov A.O., Dokhov M.A., Zakharchenko A.O., Yablonskii P.K. Signaling molecules of tumor transformation in tuberculosis. Molekulyarnaya meditsina. 2022; 20 (6): 12–15 https://doi.org/10.29296/24999490-2022-06-02 (in Russian)].
- Кудряшов Г.Г., Нефедов А.О., Точильников Г.В., Змитриченко Ю.Г., Крылова Ю.С., Догонадзе М.З., Заболотных Н.В., Дьякова М.Е., Эсмедляева Д.С., Витовская М.Л., Гаврилов П.В., Азаров А.А., Журавлев В.Ю., Виноградова Т.И., Яблонский П.К. Оригинальная экспериментальная модель туберкулеза и рака легкого. Педиатр. 2022: 13 (5): 33–42. DOI: https://doi.org/10.17816/PED13533-42 [Kudrjashov G.G., Nefedov A.O., Tochil’nikov G.V., Zmitrichenko Ju.G., Krylova Ju.S., Dogonadze M.Z., Zabolotnyh N.V., D’jakova M.E., Jesmedljaeva D.S., Vitovskaja M.L., Gavrilov P.V., Azarov A.A., Zhuravlev V.Ju., Vinogradova T.I., Jablonskij P.K. Original’naja jeksperimental’naja model’ tuberkuleza i raka legkogo. Pediatr. 2022: 13 (5): 33–42. DOI: https://doi.org/10.17816/PED13533-42 (in Russian)].
- Вершинина С.Ф., Стуков А.Н. Экспериментальные опухоли: Практическое руководство. СПб.: Изд-во Галаника, 2018. [Vershinina S.F., Stukov A.N. Jeksperimental’nye opuholi: Prakticheskoe rukovodstvo. SPb.: Izd-vo Galanika, 2018 (in Russian)]
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