Еffect of tripeptides on growth of organotypic culture of different genesis tissues
- Authors: Chalisova N.I.1,2, Ryzhak G.A.2, Umnov R.S.2, Linkova N.S.2,3
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Affiliations:
- Pavlov Institute of Physiology RAS
- Saint Petersburg Institute of Bioregulation and Gerontology
- Belgorod National Research University
- Issue: Vol 20, No 3 (2022)
- Pages: 30-33
- Section: Articles
- URL: https://journal-vniispk.ru/1728-2918/article/view/143940
- DOI: https://doi.org/10.29296/24999490-2022-03-04
- ID: 143940
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Abstract
Tripeptides are physiological products of protein degradation and informational molecules. AED (Ala-Glu-Asp), EDR (Glu-Asp-Arg), EDG (Glu-Asp-Gly) peptides have geroprotective, neuroprotective, reparative and antioxidant properties. The aim of the work is to evaluate the effect of the AED, EDR, EDG peptides on the development of organotypic tissue culture of various genesis in young and old rats. Material and methods. Tissues for organotypic cultivation of mesodermal genesis (testis), ectodermal genesis (cerebral cortex) and entodermalgenesis (bladder) were obtained from young (2-3 months) and old (16-18 months) Wistar rats. Results. AED peptide stimulated cell growth in meso- and endodermal tissues of young and old animals. EDR peptide activated cell proliferation in ecto- and mesodermal tissues of young and old rats. EDG peptide had a stimulating effect on the mesodermal tissue of young rats. Conclusion. Tripeptides, depending on the composition and sequence of their amino acids, have different effects on meso-, ecto- and endodermal genesis tissues obtained from animals of different ages. This indicates the possibility of targeted geroprotective action of AED, EDR, EDG peptides.
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##article.viewOnOriginalSite##About the authors
Natalia Iosifovna Chalisova
Pavlov Institute of Physiology RAS; Saint Petersburg Institute of Bioregulation and Gerontology
Author for correspondence.
Email: ni-chalisova@mail.ru
leading researcher; senior researcher of the laboratory of Oncogerontology of Biogerontology department
Galina Anatol’evna Ryzhak
Saint Petersburg Institute of Bioregulation and Gerontology
Email: galina@gerontology.ru
associate Director
Roman Sergeevich Umnov
Saint Petersburg Institute of Bioregulation and Gerontology
Email: t.kmb@mail.ru
the scientific researcher of the Laboratory of Biogerontology of the Department ofBiogerontology
Natalia Sergeevna Linkova
Saint Petersburg Institute of Bioregulation and Gerontology; Belgorod National Research University
Email: miayy@yandex.ru
the head of the laboratory of molecular mechanisms of aging; Senior researcher of the Laboratory “Problem of Aging”
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