Signaling molecules of tumor transformation in tuberculosis
- Autores: Krylova Y.S.1,2, Kudriashov G.G.1, Nefedov A.O.1, Dokhov M.A.1,3, Zakharchenko A.O.4, Yablonskii P.K.1,4
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Afiliações:
- Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation
- Pavlov First Saint Petersburg State Medical University
- St. Petersburg State Pediatric Medical University
- Saint-Petersburg University
- Edição: Volume 20, Nº 6 (2022)
- Páginas: 12-15
- Seção: Reviews
- URL: https://journal-vniispk.ru/1728-2918/article/view/143965
- DOI: https://doi.org/10.29296/24999490-2022-06-02
- ID: 143965
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Resumo
The review is devoted to the analysis of modern ideas about the molecular mechanisms of tumor transformation in tuberculosis; signal molecules are described, which may be biomarkers and targets for optimizing personalized diagnosis and targeted therapy of the disease.
The aim of the study was to determine the current state of the issue and characterize the molecular markers of tumor transformation in tuberculosis.
Material and methods: analysis and systematization of scientific literature over the past 10 years was performed in the PubMed, Scopus and Google Scholar databases.
Results: particular attention in the review is given to the factors contributing to tumor transformation in tuberculosis. Both direct effects of Mycobacterium tuberculosis on proliferation and immune response, and indirect mechanisms of action on cells involved in inflammation processes are considered. The choice of signaling molecules to optimize the personalized diagnosis of tumor transformation in tuberculosis is substantiated.
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##article.viewOnOriginalSite##Sobre autores
Yulia Krylova
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation; Pavlov First Saint Petersburg State Medical University
Autor responsável pela correspondência
Email: info@spbniif.ru
ORCID ID: 0000-0002-8698-7904
Senior Researcher, Center for Molecular Biomedicine. PhD.
Rússia, Ligovskij avenue, 2–4, Saint-Petersburg, 191036; Street L’va Tolstogo, 6–8, Saint-Petersburg, 197022Grigorii Kudriashov
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation
Email: dr.kudriashov.gg@yandex.com
ORCID ID: 0000-0002-2810-8852
Senior researcher, thoracic surgeon
Ligovskij avenue, 2–4, Saint-Petersburg, 191036Andrey Nefedov
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation
Email: herurg78@mail.ru
ORCID ID: 0000-0001-6228-182X
Senior Researcher, Head of the Department of Thoracic Oncology
Rússia, Ligovskij avenue, 2–4, Saint-Petersburg, 191036Mikhail Dokhov
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation; St. Petersburg State Pediatric Medical University
Email: info@spbniif.ru
ORCID ID: 0000-0002-7834-5522
Senior Researcher of the Center for Molecular Biomedicine
Rússia, Ligovskij avenue, 2–4, Saint-Petersburg, 191036; Litovskaya street, 2, Saint-Petersburg, 194100Aleksandra Zakharchenko
Saint-Petersburg University
Email: alz121@mail.ru
ORCID ID: 0000-0002-5398-0167
student of the Medical Faculty
Rússia, Universitetskaya Embankment, 7–9, Saint-Petersburg, 199034Piotr Yablonskii
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation; Saint-Petersburg University
Email: info@spbniif.ru
ORCID ID: 0000-0003-4385-9643
director. MD, PhD, professor
Rússia, Ligovskij avenue, 2–4, Saint-Petersburg, 191036; Universitetskaya Embankment, 7–9, Saint-Petersburg, 199034Bibliografia
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