Is the progression of tuberculosis possible against the background of antitumor therapy for lung cancer? Results of an experimental study
- 作者: Kudriashov G.G.1, Vinogradova T.I.1, Zmitrichenko Y.G.2, Krylova Y.S.1, Dogonadze M.Z.1, Zabolotnyh N.V.1, Dyakova M.E.1, Esmedlyaeva D.S.1, Tochilnikov G.V.2, Nefedov A.O.1, Agafonov G.M.1,3, Yablonskiy P.K.1,3
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隶属关系:
- Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation
- N.N. Petrov National Medicine Research Center of oncology
- Federal State Budgetary Educational Institution of Higher Education “Saint-Petersburg State University”
- 期: 卷 23, 编号 3 (2025)
- 页面: 77-85
- 栏目: Original research
- URL: https://journal-vniispk.ru/1728-2918/article/view/312102
- DOI: https://doi.org/10.29296/24999490-2025-03-10
- ID: 312102
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Aim of the study. The possibility of using antitumor drugs against the background of active tuberculosis is an unresolved problem of modern medicine. The aim of the experimental study was to study the course of tuberculosis infection against the background of antitumor therapy for lung cancer and combined antitumor and anti-tuberculosis chemotherapy.
Material and methods. The study was conducted on two-month-old C57BL/6 mice infected by intravenous injection of the reference strain Mycobacterium tuberculosis H37Rv. On the third day after infection, antitumor drugs (isoniazid, rifampicin, pyrazinamide and ethambutol) and/or a combination of anti-tuberculosis and antitumor drugs were given out. There were 2 control groups (infection control and control of anti-tuberculosis therapy) and 14 experimental groups (in dependence of antitumor drugs of cisplatin, carboplatin, gemcitabine, pemetrexed, etoposide, paclitaxel and docetaxel). Clinical, laboratory, bacteriological, morphological and morphometric parameters, and mortality were evaluated. Nonparametric methods of medical statistics were used.
Results. The isolated use of cisplatin, etoposide and docetaxel led to an increase in the mortality of experimental animals compared with infection control. However, there were no differences in survival between the experimental and control groups in the groups of combined use of antitumor (ATT) and anti-tuberculosis (ATBT) drugs. The combination of ATBT and gemcitabine was accompanied by a significantly lower level of inflammatory response (decreased activity of ceruloplasmin). The maximum inflammatory response was recorded with a combination of ATBT and pemetrexed, which was expressed in an increase in the activity of elastase, transaminases and ADA-1. There was a decrease in the intensity of MTB reproduction in all groups of combined therapy when comparing ATT with a combination of ATT +ATBT. It should be noted that the complete elimination of MTB was achieved only with the combination of ATBT with gemcitabine and etoposide.
Conclusion. The combination of anti-tuberculosis therapy with antitumor drugs does not reliably lead to a fatal progression of the infectious process in the lungs and in some cases makes it possible to achieve complete suppression of the reproduction of Mycobacterium tuberculosis. The most promising schemes of antitumor therapy in conditions of active tuberculosis infection are schemes using carboplatin and gemcitabine, taking into account low mortality, lower toxicity and better effect of anti-tuberculosis therapy against the background of combined use.
作者简介
Grigorii Kudriashov
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation
编辑信件的主要联系方式.
Email: dr.kudriashov.gg@yandex.com
ORCID iD: 0000-0002-2810-8852
SPIN 代码: 9289-6479
Candidate of Medical Sciences, Head of the Department of Pulmonology and Thoracic Surgery, Thoracic Surgeon of the Tuberculosis Pulmonary Surgical (Thoracic) Department No.3
俄罗斯联邦, Ligovskiy ave., 2–4, St. Petersburg, 191036Tatiana Vinogradova
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation
Email: ti.vinogradova@spbniif.ru
ORCID iD: 0000-0002-5234-349X
SPIN 代码: 6354-5070
Doctor of Medical Sciences, Chief Researcher
俄罗斯联邦, Ligovskiy ave., 2–4, St. Petersburg, 191036Yuliya Zmitrichenko
N.N. Petrov National Medicine Research Center of oncology
Email: zmitrichenko@gmail.com
ORCID iD: 0000-0002-9137-9532
SPIN 代码: 6122-3450
Junior Researcher, Scientific Laboratory of Cancer Chemoprevention and Oncopharmacology
俄罗斯联邦, Leningradskaya str., 68, village Pesochny, St. Petersburg, 197758Yulia Krylova
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation
Email: emerald2008@mail.ru
ORCID iD: 0000-0002-8698-7904
SPIN 代码: 9729-7872
Candidate of Medical Sciences, Senior Researcher at the Center for Molecular Biomedicine
俄罗斯联邦, Ligovskiy ave., 2–4, St. Petersburg, 191036Marine Dogonadze
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation
Email: marine-md@mail.ru
ORCID iD: 0000-0002-9161-466X
SPIN 代码: 7475-9828
Candidate of Medical Sciences, Senior Researcher
俄罗斯联邦, Ligovskiy ave., 2–4, St. Petersburg, 191036Natalia Zabolotnyh
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation
Email: info@spbniif.ru
ORCID iD: 0000-0002-2946-2415
SPIN 代码: 7048-8630
Doctor of Medical Sciences, Leading Researcher
俄罗斯联邦, Ligovskiy ave., 2–4, St. Petersburg, 191036Marina Dyakova
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation
Email: marinadyakova@yandex.ru
ORCID iD: 0000-0002-7810-880X
SPIN 代码: 7858-4573
Doctor of Biological Sciences, Senior Researcher
俄罗斯联邦, Ligovskiy ave., 2–4, St. Petersburg, 191036Dilyara Esmedlyaeva
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation
Email: diljara-e@yandex.ru
ORCID iD: 0000-0002-9841-0061
SPIN 代码: 9402-4487
Candidate of Biological Sciences, Senior Researcher
俄罗斯联邦, Ligovskiy ave., 2–4, St. Petersburg, 191036Grigorii Tochilnikov
N.N. Petrov National Medicine Research Center of oncology
Email: gr75@mail.ru
ORCID iD: 0000-0003-4232-8170
SPIN 代码: 4366-6930
Candidate of Medical Sciences, Head of the Scientific Laboratory of Cancer Chemoprevention and Oncopharmacology
俄罗斯联邦, Leningradskaya str., 68, village Pesochny, St. Petersburg, 197758Andrey Nefedov
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation
Email: herurg78@mail.ru
ORCID iD: 0000-0001-6228-182X
SPIN 代码: 2365-9458
Candidate of Medical Sciences, Senior Researcher, Head of the Department of Thoracic Oncology
俄罗斯联邦, Ligovskiy ave., 2–4, St. Petersburg, 191036Georgiy Agafonov
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation; Federal State Budgetary Educational Institution of Higher Education “Saint-Petersburg State University”
Email: g.agafonov.98@gmail.com
ORCID iD: 0000-0002-1701-4180
SPIN 代码: 4693-8118
Junior Researcher, Resident, Department of Hospital Surgery of the Faculty of Medicine
俄罗斯联邦, Ligovskiy ave., 2–4, St. Petersburg, 191036; Universitetskaya emb., 7/9, Saint Petersburg, 199034Piotr Yablonskiy
Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation; Federal State Budgetary Educational Institution of Higher Education “Saint-Petersburg State University”
Email: piotr_yablonskii@mail.ru
ORCID iD: 0000-0003-4385-9643
SPIN 代码: 3433-2624
Doctor of Medicine, Professor, Head of Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation; Vice-Rector for Medicine
俄罗斯联邦, Ligovskiy ave., 2–4, St. Petersburg, 191036; Universitetskaya emb., 7/9, Saint Petersburg, 199034参考
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