Polypeptide effect on stimulation of experimental animals cellular proliferation
- Autores: Ryzhak G.A.1,2,3, Chalisova N.I.1,2,3, Ivanova P.N.1,2,3, Egozova E.S.1,2,3
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Afiliações:
- Pavlov Institute of Physiology of the Russian Academy of Sciences
- Saint Petersburg Institute of Bioregulation and Gerontology
- Herzen State Pedagogical University of Russia
- Edição: Volume 21, Nº 3 (2023)
- Páginas: 39-42
- Seção: Original research
- URL: https://journal-vniispk.ru/1728-2918/article/view/250429
- DOI: https://doi.org/10.29296/24999490-2023-03-05
- ID: 250429
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Resumo
Introduction. The study of mechanisms of multicellular system regulation and of cellular proliferation and apoptosis balanced status in the organism tissues is one of the actual task of modern biology and medicine.
Purpose of study. Effect of polypeptide complexes (PPCs) from liver (Wentwil) and of bladder (Wesustim). and of corresponding short peptides. on the cellular proliferation in liver and bladder tissues of mammalian and birds.
Methods. Organotypic tissue culture of rat and 17-days chick embryo liver, bladder under different PPCs and short peptides was used for quick biologically activity of peptides screening.
Results. The tissue specific effect of PPC and short peptides on liver and bladder of different animals types. The square index (SI) of explants was increased statistically reliable on 21–29%, as compared to the control.
Conclusion. The data obtained produce the base for working and quick testing of preparations for treatment of patients with pathology in liver and bladder tissues.
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##article.viewOnOriginalSite##Sobre autores
Galina Ryzhak
Pavlov Institute of Physiology of the Russian Academy of Sciences; Saint Petersburg Institute of Bioregulation and Gerontology; Herzen State Pedagogical University of Russia
Email: galina@gerontology.ru
ORCID ID: 0000-0003-2536-1438
associate Director of Saint Petersburg Institute of Bioregulation and Gerontology in scientific investigation, doctor of medical sciences, рrofessor
nab. Makarova, 6, St. Petersburg, 199034; Ave. Dinamo 3, St. Petersburg, 197110; emb. Moika 48, St. Petersburg, 191186Natalia Chalisova
Pavlov Institute of Physiology of the Russian Academy of Sciences; Saint Petersburg Institute of Bioregulation and Gerontology; Herzen State Pedagogical University of Russia
Email: ni_chalisova@mail.ru
ORCID ID: 0000-0002-2371-0043
expert scientific worker of the I.P. Pavlov Institute of Physiology RAS, expert scientific worker of the laboratory of Oncogerontology of Biogerontology department of Saint Petersburg Institute of Bioregulation and Gerontology, doctor of biologic sciences, professor
Rússia, nab. Makarova, 6, St. Petersburg, 199034; Ave. Dinamo 3, St. Petersburg, 197110; emb. Moika 48, St. Petersburg, 191186Polina Ivanova
Pavlov Institute of Physiology of the Russian Academy of Sciences; Saint Petersburg Institute of Bioregulation and Gerontology; Herzen State Pedagogical University of Russia
Email: ivanovapolina19@mail.ru
ORCID ID: 0000-0001-7112-0673
scientific worker of Petersburg Institute of bioregulation and Gerontology
Rússia, nab. Makarova, 6, St. Petersburg, 199034; Ave. Dinamo 3, St. Petersburg, 197110; emb. Moika 48, St. Petersburg, 191186Ekaterina Egozova
Pavlov Institute of Physiology of the Russian Academy of Sciences; Saint Petersburg Institute of Bioregulation and Gerontology; Herzen State Pedagogical University of Russia
Autor responsável pela correspondência
Email: ekaterina_egozova@mail.ru
ORCID ID: 0000-0002-0055-3778
magister of Herzen State Pedagogical University of Russia
Rússia, nab. Makarova, 6, St. Petersburg, 199034; Ave. Dinamo 3, St. Petersburg, 197110; emb. Moika 48, St. Petersburg, 191186Bibliografia
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