Comparative analysis of biomechanical properties of grafts and intact tunica albuginea in experiment
- Авторлар: Kotov S.V.1, Sokolov N.M.1,2, Yapina A.A.1, Yusufov A.G.1,2, Titkova S.M.1, Klimenko E.I.3, Raksha A.P.1,3, Anurov M.V.1
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Мекемелер:
- Pirogov Russian National Research Medical University
- Kommunarka Moscow Multidisciplinary Clinical Center
- Pirogov City Clinical Hospital No. 1
- Шығарылым: № 4 (2025)
- Беттер: 5-13
- Бөлім: ORIGINAL ARTICLES
- URL: https://journal-vniispk.ru/1728-2985/article/view/316540
- DOI: https://doi.org/10.18565/urology.2025.4.5-13
- ID: 316540
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Аннотация
Introduction. Existing treatment methods for Peyronie's disease (PD) aim to restore the normal biomechanical functions of the tunica albuginea (TA); however, current data on biomechanical changes in PD, as well as on the biomechanical properties of native human TA, are extremely limited. The aim of our study was to evaluate the biomechanical properties of intact TA and the materials most commonly used for its replacement.
Materials and Methods. Samples of the TA were collected from 9 male cadavers aged 20 to 65 years. Rectangular sections of the TA were excised from the dorsal surface of the corpora cavernosa. Fixation of the specimens in formalin was not performed, as this could affect the biomechanical properties of the tissue. Prepared samples were divided into longitudinal and transverse fragments. Pericardial grafts (allograft from cadaveric pericardium; xenograft from bovine pericardium) were prepared similarly. The obtained tissue fragments were subjected to mechanical testing. All tensile tests were conducted using a single-column universal material testing machine, the TA.XTplus Texture Analyzer (Stable Micro Systems Ltd., UK). Interactive stress-strain curves were used for result analysis. The following parameters were determined: stress, strength, strain, sample thickness. The obtained data were subjected to statistical analysis.
Results. Analysis of the obtained data revealed that the stress and strength of longitudinal fragments of TA were statistically significantly higher (p = 0,0004 and p = 0,0008; Tukey’s test) than those for the transverse fragments. This indicates that human TA is anisotropic. Correlation analysis showed a negative correlation between the patient age and the strength (r = –0,49; p < 0,05; Spearman’s rank correlation). Additionally, a negative correlation was found between the patient’s age and the thickness of their tunica albuginea (r = –0,56; p < 0,05 according to Spearman’s test). When comparing human TA with grafts from bovine and human pericardium, it was found that the strength and thickness calculated for human tunica albuginea were statistically significantly higher (p = 0,0001; Tukey’s test) than those for the grafts.
Conclusions. Human and bovine pericardium grafts significantly differ from healthy TA in terms of stress, elastic modulus, strength, and thickness, which may impact the outcomes of surgical treatment for patients with PD.
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##article.viewOnOriginalSite##Авторлар туралы
Sergey Kotov
Pirogov Russian National Research Medical University
Email: urokotov@mail.ru
ORCID iD: 0000-0003-3764-6131
Dr. Sc. (Med.), Professor, Head of the Lopatkin Urology and Andrology Department of the Institute of Surgery
Ресей, 1, Ostrovityanov St., Moscow, 117997Nikita Sokolov
Pirogov Russian National Research Medical University; Kommunarka Moscow Multidisciplinary Clinical Center
Хат алмасуға жауапты Автор.
Email: 4eaman@gmail.com
ORCID iD: 0000-0001-9091-8189
Postgraduate Student of the Lopatkin Urology and Andrology Department of the Institute of Surgery; Urologist
Ресей, 1, Ostrovityanov St., Moscow, 117997; 8, Sosensky Stan St., Sosenskoe Village, Moscow, 108814Anna Yapina
Pirogov Russian National Research Medical University
Email: yapina0@mail.ru
ORCID iD: 0009-0008-9092-4472
Student at the Faculty of Medicine
Ресей, 1, Ostrovityanov St., Moscow, 117997Anvar Yusufov
Pirogov Russian National Research Medical University; Kommunarka Moscow Multidisciplinary Clinical Center
Email: anvar.yusufov@mail.ru
ORCID iD: 0000-0001-8202-3844
Cand. Sc. (Med.), Associate Professor at the Lopatkin Urology and Andrology Department of the Institute of Surgery; Head of the Urology Department
Ресей, 1, Ostrovityanov St., Moscow, 117997; 8, Sosensky Stan St., Sosenskoe Village, Moscow, 108814Svetlana Titkova
Pirogov Russian National Research Medical University
Email: stitkova63@yandex.ru
ORCID iD: 0000-0001-5477-0084
Senior Researcher at the Experimental Surgery Department of the Institute of Surgery
Ресей, 1, Ostrovityanov St., Moscow, 117997Ekaterina Klimenko
Pirogov City Clinical Hospital No. 1
Email: 4eaman@gmail.com
Pathologist at the Morbid Anatomy Department
Ресей, 8, Leninsky Ave., Moscow, 119049Alexander Raksha
Pirogov Russian National Research Medical University; Pirogov City Clinical Hospital No. 1
Email: 4eaman@gmail.com
Dr. Sc. (Med.), Professor at the Department of Pathological Anatomy and Clinical Pathological Anatomy of the Institute of Human Biology and Pathology; Head of the Morbid Anatomy Department
Ресей, 1, Ostrovityanov St., Moscow, 117997; 8, Leninsky Ave., Moscow, 119049Mikhail Anurov
Pirogov Russian National Research Medical University
Email: anurov@rsmu.ru
ORCID iD: 0000-0001-7512-2641
Dr. Sc. (Med.), Head of the Experimental Surgery Department of the Institute of Surgery
Ресей, 1, Ostrovityanov St., Moscow, 117997Әдебиет тізімі
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