Cancer of the vermilion border of the lower lip ranks first among all oral cancers. The real high quantitative parameters during radiotherapy for cancer at this site, in its stages I and II in particular, are comparable to those only in the same stages of skin cancer. This could lead to the incompletely substantiated optimistic point of view that the problem of radiotherapy for cancer of the vermilion border of the lower lip is mostly solved now. The assessment of the results of radiotherapy for Stage III and a fortiori Stage IV is not so optimistic. The paper assesses the results of radiotherapy in 513 patients with malignant tumors of the vermilion border of the lower lip. The radiotherapy was planned and implemented by the author. The central region of the lower lip, the right half, and the left half were affected in 121 (23,2%), 188 (36,6), and 204 (39,8%) patients, respectively. There was exophytic tumor growth in 250 (48,7%) patients, ulcerative and endophytic growth in 193 (37,6%) and 70 (13,7%), respectively. Cancers of different grades occurred in 512 (99,8%) patients, including 509 (99,2%) with squamous cell carcinoma, 3 with high-grade carcinoma, and 1 with fibrosarcoma. Stage I was seen in 175 (34,1%) patients, Stage II in 236 (46,0%), including 221 patients with Stage IIa and 15 with IIb; Stage III was diagnosed in 98 (19,1%) patients, of whom there were 70 patients with Stage IIIa and 28 with Stage IIIb; Stage IV was present in 3 patients who all had regional metastases.