Correction of neurogenesis in the adult brain: Selection of therapeutic targets

Abstract

Endogenous neurogenesis results in the formation of new neural structures that are prerequisites for numerous functions of the adult brain. Neurogenesis is promoted by a large number of regulatory processes when structural and functional support is required. Adaptive neurogenesis may be stimulated by influencing separate signaling elements, such as neuromediators and transduction, transcription, and epigenetic factors. Here, we analyze data on targeted influence on neurogenesis as a novel therapeutic approach. Neurogenesis should be considered in general as a systemic target; by influencing it, it is possible to correct functions disturbed in ischemia, stroke, neurodegenerative disorders, traumas, and psychic pathologies or to perform adaptive support and stimulation of normal physiological functions (memory, cognitive processes, social adaptation, etc.).