Corticotropin-Releasing Factor (CRF) and Somatic Pain Sensitivity: the Contribution of CRF Receptors of Subtypes 1 and 2

Abstract

Corticotropin-releasing factor (CRF) coordinates behavioral, endocrine, and autonomic responses under stress. CRF action is mediated by CRF receptors of subtype 1 and 2 (CRF-1 and CRF-2 receptors, respectively). In this review, we analyze data on the roles of the CRF-1 and CRF-2 receptors in somatic pain regulation. We review the contribution of these receptors to the CRF-induced analgesic effect (at its local, systemic (peripheral), and central administration). The literature data indicates that both types of CRF receptors are involved in the CRF-induced analgesic effect on somatic pain sensitivity; however, the functional roles of these receptors may be different. The initiation and development of the pain reaction is associated with activation of CRF-1 receptors, whereas the functional role of CRF-2 receptors is to limit the action of a pain stimulus.