Gastrodia elata  Blume-Derived Vanillyl Alcohol Suppresses Amyloid β-Peptide-Induced Caspase Activation in SH-SY5Y Cells

Young-Ji Choi; Mi-Hee Kim; In-Sun Park; Bora Kwon; Young-Moo Choo; Seung-Il Jeong; Kang-Yeol Yu; Jiyoung Kim

doi:10.1134/S1819712419010070

Gastrodia elata Blume-Derived Vanillyl Alcohol Suppresses Amyloid β-Peptide-Induced Caspase Activation in SH-SY5Y Cells

Authors: Choi Y.¹, Kim M.¹, Park I.¹, Kwon B.¹, Choo Y.¹, Jeong S.¹, Yu K.¹, Kim J.¹
Affiliations:
1. Jeonju AgroBio-Materials Institute
Issue: Vol 13, No 1 (2019)
Pages: 110-112
Section: Short Communications
URL: https://journal-vniispk.ru/1819-7124/article/view/211694
DOI: https://doi.org/10.1134/S1819712419010070
ID: 211694

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Abstract

In this study, we isolated and characterized Gastrodia elata Blume-derived vanillyl alcohol (GEVA) to elucidate biomedical efficacies in improving memory. Acetylcholinesterase (AChE) inhibition assay revealed that GEVA has an inhibitory activity against AChE. In addition, GEVA inhibited amyloid β-peptide (Aβ_25–35)-induced caspase (CASP)-3/7 activities in SH-SY5Y cells. Therefore, this work indicates that GEVA may be effective in preventing memory loss.