Effect of solvent type and concentration on size and morphology of arbidol microparticles obtained by supercritical antisolvent precipitation

A. M. Vorobei; O. I. Pokrovskiy; K. B. Ustinovich; L. I. Krotova; O. O. Parenago; V. V. Lunin

doi:10.1134/S1990793116070198

Effect of solvent type and concentration on size and morphology of arbidol microparticles obtained by supercritical antisolvent precipitation

Authors: Vorobei A.M.¹^,2, Pokrovskiy O.I.¹, Ustinovich K.B.¹, Krotova L.I.³, Parenago O.O.¹^,2, Lunin V.V.¹^,2
Affiliations:
1. Kurnakov Institute of General and Inorganic Chemistry
2. Department of Chemistry
3. Institute of Laser and Information Technologies
Issue: Vol 10, No 7 (2016)
Pages: 1072-1077
Section: Article
URL: https://journal-vniispk.ru/1990-7931/article/view/198467
DOI: https://doi.org/10.1134/S1990793116070198
ID: 198467

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Abstract

The capability of arbidol microparticle preparation by supercritical antisolvent (SAS) precipitation was demonstrated. A nonmonotonic dependence of the average particle size on the concentration was found, while the position of the minimum is dependent on the type of solvent used. It is possible to prepare Arbidol particles of various morphology and size from several microns to several hundred microns depending on the conditions.