Email this article Impregnation of Ultra-High-Density Polyethylene with Unsymmetrical Disulfides in Subcritical Freon Media
- Authors: Zalepugin D.Y.1, Maksimkin A.V.2, Kiselevsky M.V.2,3, Tilkunova N.A.1, Anisimova N.Y.2,3, Chernyshova I.V.1, Spirina T.S.3, Senatov F.S.3, Vlasov M.I.1
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Affiliations:
- State Plant of Medicinal Drugs
- National University of Science and Technology “MISIS”
- Blokhin Russian Cancer Research Center
- Issue: Vol 11, No 7 (2017)
- Pages: 1173-1179
- Section: Article
- URL: https://journal-vniispk.ru/1990-7931/article/view/200001
- DOI: https://doi.org/10.1134/S1990793117070223
- ID: 200001
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Abstract
For the first time, ultra-high-density polyethylene (UHDPE) samples impregnated with antibacterial unsymmetrical disulfides (allyl benzothiazol-2-yl disulfide and allyl 8-quinolyl disulfide) were obtained in subcritical freon R22 in the absence of organic solvents as modifiers. Freon R22 was completely removed from the impregnated samples that provided a high purity of the final material. Potential implants based on the UHDPE impregnated with unsymmetrical disulfides were shown to manifest antibacterial and antifungal activity.
About the authors
D. Yu. Zalepugin
State Plant of Medicinal Drugs
Author for correspondence.
Email: zaledmit@gmail.com
Russian Federation, Moscow, 111024
A. V. Maksimkin
National University of Science and Technology “MISIS”
Email: zaledmit@gmail.com
Russian Federation, Moscow, 119049
M. V. Kiselevsky
National University of Science and Technology “MISIS”; Blokhin Russian Cancer Research Center
Email: zaledmit@gmail.com
Russian Federation, Moscow, 119049; Moscow, 115478
N. A. Tilkunova
State Plant of Medicinal Drugs
Email: zaledmit@gmail.com
Russian Federation, Moscow, 111024
N. Yu. Anisimova
National University of Science and Technology “MISIS”; Blokhin Russian Cancer Research Center
Email: zaledmit@gmail.com
Russian Federation, Moscow, 119049; Moscow, 115478
I. V. Chernyshova
State Plant of Medicinal Drugs
Email: zaledmit@gmail.com
Russian Federation, Moscow, 111024
T. S. Spirina
Blokhin Russian Cancer Research Center
Email: zaledmit@gmail.com
Russian Federation, Moscow, 115478
F. S. Senatov
Blokhin Russian Cancer Research Center
Email: zaledmit@gmail.com
Russian Federation, Moscow, 115478
M. I. Vlasov
State Plant of Medicinal Drugs
Email: zaledmit@gmail.com
Russian Federation, Moscow, 111024
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