Email this article Supercritical Fluid Treatment of Three-Dimensional Hydrogel Matrices Obtained from Allylchitosan by Laser Stereolithography
- Authors: Lazhko A.E.1,2, Bardakova K.N.1,3, Shavkuta B.S.1, Churbanov S.N.1, Markov M.A.4, Akopova T.A.5, Parenago O.O.2,6, Grigoryev A.M.7, Timashev P.S.1,3, Lunin V.V.2,6, Bagratashvili V.N.1,2
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Affiliations:
- Institute of Photon Technologies, Crystallography and Photonics Research Center
- Faculty of Chemistry
- Institute of Regenerative Medicine
- Institute of Problems of Laser and Information Technologies
- Enikolopov Institute of Synthetic Polymer Materials
- Kurnakov Institute of General and Inorganic Chemistry
- Academician Shumakov Federal Research Center of Transplantation and Artificial Organs
- Issue: Vol 12, No 7 (2018)
- Pages: 1144-1151
- Section: Article
- URL: https://journal-vniispk.ru/1990-7931/article/view/201414
- DOI: https://doi.org/10.1134/S1990793118070072
- ID: 201414
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Abstract
The effect of the treatment of hydrogel matrices based on allyl-substituted chitosans and formed by laser stereolithography in supercritical carbon dioxide (SC-CO2) on their surface polarity and mechanical characteristics was studied. Treatment in a flow mode increased the mechanical stability of the materials due to the effective extraction of the low-molecular components and oligomers. The surface polarity of the matrix decreased, improving its biocompatibility. The hydrogel matrices treated in SC-CO2 have no cytotoxic activity, due to which they can be used in tissue engineering.
About the authors
A. E. Lazhko
Institute of Photon Technologies, Crystallography and Photonics Research Center; Faculty of Chemistry
Author for correspondence.
Email: alexeylazhko@mail.ru
Russian Federation, Troitsk (Moscow); Moscow, 119991
K. N. Bardakova
Institute of Photon Technologies, Crystallography and Photonics Research Center; Institute of Regenerative Medicine
Email: alexeylazhko@mail.ru
Russian Federation, Troitsk (Moscow); Moscow, 119991
B. S. Shavkuta
Institute of Photon Technologies, Crystallography and Photonics Research Center
Email: alexeylazhko@mail.ru
Russian Federation, Troitsk (Moscow)
S. N. Churbanov
Institute of Photon Technologies, Crystallography and Photonics Research Center
Email: alexeylazhko@mail.ru
Russian Federation, Troitsk (Moscow)
M. A. Markov
Institute of Problems of Laser and Information Technologies
Email: alexeylazhko@mail.ru
Russian Federation, Shatura, Moscow oblast, 140700
T. A. Akopova
Enikolopov Institute of Synthetic Polymer Materials
Email: alexeylazhko@mail.ru
Russian Federation, Moscow, 117393
O. O. Parenago
Faculty of Chemistry; Kurnakov Institute of General and Inorganic Chemistry
Email: alexeylazhko@mail.ru
Russian Federation, Moscow, 119991; Moscow, 119991
A. M. Grigoryev
Academician Shumakov Federal Research Center of Transplantation and Artificial Organs
Email: alexeylazhko@mail.ru
Russian Federation, Moscow, 123182
P. S. Timashev
Institute of Photon Technologies, Crystallography and Photonics Research Center; Institute of Regenerative Medicine
Email: alexeylazhko@mail.ru
Russian Federation, Troitsk (Moscow); Moscow, 119991
V. V. Lunin
Faculty of Chemistry; Kurnakov Institute of General and Inorganic Chemistry
Email: alexeylazhko@mail.ru
Russian Federation, Moscow, 119991; Moscow, 119991
V. N. Bagratashvili
Institute of Photon Technologies, Crystallography and Photonics Research Center; Faculty of Chemistry
Email: alexeylazhko@mail.ru
Russian Federation, Troitsk (Moscow); Moscow, 119991
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