About the influence of the natural anthocyanin delphinidin on the lifespan of Drosophila melanogaster
- Authors: Platonova E.Y.1, Golubev D.A.1, Patov S.A.2, Nekrasova P.S.2, Shaposhnikov M.V.1, Moskalev A.A.1,3
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Affiliations:
- Institute of Biology, Komi Science Centre of the Ural Branch of the Russian Academy of Sciences
- Institute of Chemistry, Komi Science Centre of the Ural Branch of the Russian Academy of Sciences
- V. A. Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
- Issue: No 9 (2024)
- Pages: 92-97
- Section: Articles
- URL: https://journal-vniispk.ru/1994-5655/article/view/278520
- DOI: https://doi.org/10.19110/1994-5655-2024-9-92-97
- ID: 278520
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Abstract
Anthocyanins are vividly colored pigments that appear pink, red, blue, or violet and are dissolved in the vacuolar sap of the epidermal tissues of flowers, fruits, leaves, and stems. Delphinidin is one of the most common anthocyanins with the heroprotective potential. In this study, we examined the effect of delphinidin on the lifespan of both male and female Drosophila melanogaster. Our results showed that delphinidin concentration of 10 µM causes a statistically significant decrease in the median lifespan of male Drosophila melanogaster by 5% and an increase in median lifespan of females by 4 %. However, the mechanism of action of delphinidin on the organism is still understudied that limits our understanding of its heroprotective properties. In this context, studying the effects of delphinidin on the stress resistance, viability indicators, and the expression levels of aging-related genes in Drosophila melanogaster appears to be a promising direction. Such studies would discover the mechanisms of heroprotection and aging, as well as answer the question how natural anthocyanins like delphinidin can be used to improve human health and enlarge lifespan.
Keywords
About the authors
Elena Yu. Platonova
Institute of Biology, Komi Science Centre of the Ural Branch of the Russian Academy of Sciences
Author for correspondence.
Email: platonova.e.u@ib.komisc.ru
ORCID iD: 0000-0002-4632-2385
Scopus Author ID: 57217200914
Junior Researcher
Russian Federation, 28 Kommunisticheskaya st., Syktyvkar, Komi Republic, 167982Denis A. Golubev
Institute of Biology, Komi Science Centre of the Ural Branch of the Russian Academy of Sciences
Email: denismeatboy@gmail.com
ORCID iD: 0000-0003-0570-8211
Scopus Author ID: 57223300036
Junior Researcher
Russian Federation, 28 Kommunisticheskaya st., Syktyvkar, Komi Republic, 167982Sergey A. Patov
Institute of Chemistry, Komi Science Centre of the Ural Branch of the Russian Academy of Sciences
Email: ser-patov@yandex.ru
Candidate of Sciences (Chemistry), Researcher
Russian Federation, 48 Pervomayskaya st., Syktyvkar, Komi Republic, 167000Polina S. Nekrasova
Institute of Chemistry, Komi Science Centre of the Ural Branch of the Russian Academy of Sciences
Email: nekrasova.polina@bk.ru
Junior Researcher
Russian Federation, 48 Pervomayskaya st., Syktyvkar, Komi Republic, 167000Mikhail V. Shaposhnikov
Institute of Biology, Komi Science Centre of the Ural Branch of the Russian Academy of Sciences
Email: shaposhnikov@ib.komisc.ru
ORCID iD: 0000-0002-4625-6488
Scopus Author ID: 7004704906
Candidate of Sciences (Biology), Associate Professor, Leading Researcher
Russian Federation, 28 Kommunisticheskaya st., Syktyvkar, Komi Republic, 167982Aleksey A. Moskalev
Institute of Biology, Komi Science Centre of the Ural Branch of the Russian Academy of Sciences; V. A. Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
Email: amoskalev@ib.komisc.ru
ORCID iD: 0000-0002-3248-1633
Scopus Author ID: 7003730453
Professor, Corresponding Member of the Russian Academy of Sciences, Doctor of Sciences (Biology), Head of the Laboratory of Geroprotective and Radioprotective Technologies at the Institute of Biology, Коmi Science Centre of the Ural Branch of the Russian Academy of Sciences
Russian Federation, 28 Kommunisticheskaya st., Syktyvkar 167000, Komi Republic; MoscowReferences
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