The effect of graphene oxide (GO) on biomineralization and solubility of calcium hydroxyapatite (HA)

Abstract

Interaction between GO and the counterpart of the bone tissue, calcium hydroxyapatite Ca₁₀(PO₄)₆(OH)₂ (HA), is modeled in the course of synthesis of nanosize composite materials (CMs) based on graphene oxide (GO) and biocompatible HA with a GO content of 0.1, 1.0, 2.0, and 5.0 wt % GO from aqueous solutions in the system of Ca(OH)₂–H₃PO₄–GO–H₂O under native conditions (37°C). The effect of CM composition on the size and morphology of HA nanocrystals (HA NCs) is determined using the methods of physico-chemical analysis (chemical, XRD, IRS, DTA, TDG, SEM, TEM). The solubility of HA NC CMs by Ca²⁺ ions in distilled water is determined under in vitro conditions, and the possible results of interaction between GO and native calcified tissues are analyzed.