Intraoperative Ultrasound in Colorectal Liver Metastases

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Abstract

Intraoperative ultrasound (IOUS) is a diagnostic technique that allows obtaining additional information about the number and localization of colorectal cancer (CRC) metastases in the liver (especially with their intraparenchymal location), determining their relationship with the arteries and veins of the liver, navigating for puncture biopsy and / or performing minimally invasive treatment of lesions, and adjusting the amount of resection intervention on the liver during surgery. When performing minimally invasive medical procedures, IOUS application helps to avoid injuries to blood vessels, bile ducts and adjacent organs, and also allows evaluating the effectiveness of treatment and identifying potential complications. An important component of IOUS is the support of surgical procedures with a staged assessment of the liver hemodynamics, providing an immediate correction of the surgical situation. Thus, IOUS is a safe, inexpensive and highly informative diagnostic option, which should be a mandatory diagnostic step in the surgical treatment of CRC liver metastases.
Based on literature data and personal experience, the authors present indications, technical aspects and features of application of various IOUS options and modalities in the surgical treatment of CRC liver metastases.

About the authors

Yulia Alexandrovna Stepanova

A.V. Vishnevsky National Medical Research Center of Surgery; A.I. Evdokimov Moscow State University of Medicine and Dentistry

Email: stepanovaua@mail.ru
ORCID iD: 0000-0002-2348-4963
SPIN-code: 1288-6141

MD, Professor; Academic Secretary; prof. of Surgery and Surgical Technologies Department

Russian Federation, 27, Bolshaya Serpukhovskaya street, Moscow, 117997; 20/1, Delegatskaya street, Moscow, 127473

Dmitry Anatolyevich Ionkin

A.V. Vishnevsky National Medical Research Center of Surgery

Email: da.ionkin@gmail.com
ORCID iD: 0000-0002-4903-5293
SPIN-code: 1075-0861

Cand. of Med. Sci., Senior Researcher of the Oncology Department of Surgical Methods of Treatment

Russian Federation, 27, Bolshaya Serpukhovskaya street, Moscow, 117997

Olga Ivanovna Zhavoronkova

A.V. Vishnevsky National Medical Research Center of Surgery

Email: zhavoronkovaoi@yandex.ru
ORCID iD: 0000-0002-8598-8008

Cand. of Med. Sci., Senior Researcher of Ultrasound Diagnostics Department

Russian Federation, 27, Bolshaya Serpukhovskaya street, Moscow, 117997

Yan Yanovich Gavrilov

A.V. Vishnevsky National Medical Research Center of Surgery

Email: jngavrilov@mail.ru
ORCID iD: 0000-0003-0716-5353
SPIN-code: 5293-7828

Junior Researcher of Ultrasound Diagnostics Department

Russian Federation, 27, Bolshaya Serpukhovskaya street, Moscow, 117997

Aleksey Vladimirovich Zhao

A.V. Vishnevsky National Medical Research Center of Surgery

Email: alexeyzhao@gmail.com
ORCID iD: 0000-0002-0204-8337
SPIN-code: 1101-6874

Doc. of Med. Sci., Prof., Head of the Oncology Department of Surgical Methods of Treatment

Russian Federation, 27, Bolshaya Serpukhovskaya street, Moscow, 117997

Vladimir Aleksandrovich Vishnevsky

A.V. Vishnevsky National Medical Research Center of Surgery

Author for correspondence.
Email: v-vishnevskii@mail.ru
ORCID iD: 0000-0003-1467-5853

Doc. of Med. Sci., Prof., Advisor to the Director for Surgery

Russian Federation, 27, Bolshaya Serpukhovskaya street, Moscow, 117997

References

  1. Yamakawa K., Naito S., Azuma K., Wagai T. Laparoscopic diagnosis of the intraabdominal organs. Jpn J Gastroenterol. 1958; 55: 741-747.
  2. Kruskal J.B., Kane R.A. Intraoperative ultrasonography of the liver. Crit Rev Diagn Imaging. 1995; 36(3): 175-226.
  3. Makuuchi M., Torzilli G., Machi J. History of intraoperative ultrasound. Ultrasound Med Biol. 1998 Nov; 24(9): 1229-1242. doi: 10.1016/s0301-5629(98)00112-4
  4. Staren E.D., Gambla M., Deziel D.J., Velasco J., Saclarides T.J., Millikan K., Doolas A. Intraoperative ultrasound in the management of liver neoplasms. Am Surg. 1997 Jul; 63(7): 591-596.
  5. Makuuchi M., Hasegawa H., Yamazaki S. Ultrasonically guided subsegmentectomy. Surg Gynecol Obstet. 1985 Oct; 161(4): 346-350.
  6. Livraghi T., Giorgio A., Marin G., Salmi A., de Sio I., Bolondi L., Pompili M., Brunello F., Lazzaroni S., Torzilli G. Hepatocellular carcinoma and cirrhosis in 746 patients: long-term results of percutaneous ethanol injection. Radiology. 1995 Oct; 197(1): 101-108. doi: 10.1148/radiology.197.1.7568806
  7. Adam R., Majno P., Castaing D., Giovenardi R., Bismuth H. Treatment of irresectable liver tumours by percutaneous cryosurgery. Br J Surg. 1998 Nov; 85(11) 1493-1494. doi: 10.1046/j.1365-2168.1998.00880.x
  8. Solbiati L., Livraghi T., Goldberg S.N., Ierace T., Meloni F., Dellanoce M., Cova L., Halpern E.F., Gazelle G.S. Percutaneous radio-frequency ablation of hepatic metastases from colorectal cancer: long-term results in 117 patients. Radiology. 2001 Oct; 221(1): 159-166. doi: 10.1148/radiol.2211001624
  9. Solomon M.J., Stephen M.S., Gallinger S., White G.H. Does intraoperative hepatic ultrasonography change surgical decision making during liver resection? Am J Surg. 1994 Oct; 168(4): 307-310. doi: 10.1016/s0002-9610(05)80154-0
  10. Luck A.J., Maddern G.J. Intraoperative abdominal ultrasonography. Br J Surg. 1999 Jan; 86(1): 5-16. doi: 10.1046/j.1365-2168.1999.00990.x,
  11. Timoshin A.D., Shestakov A.L., Gotye S.V. et al. Intraoperative ultrasonography in case of liver metastases. Materials. 3rd Conference of Surgeons-Hepatologists, "New Technologies in Surgical Hepatology". - St. Petersburg, 1995; 69–70. (In Russ.)
  12. Grundmann R.T., Hermanek P., Merkel S., Germer C.T., Grundmann R.T., Hauss J., Henne-Bruns D., Herfarth K., Hermanek P., Hopt U.T., Junginger T., Klar E., Klempnauer J., Knapp W.H., Kraus M., Lang H., Link K.H., Löhe F., Merkel S., Oldhafer K.J., Raab H.R., Rau H.G., Reinacher-Schick A., Ricke J., Roder J., Schäfer A.O., Schlitt H.J., Schön M.R., Stippel D., Tannapfel A., Tatsch K., Vogl T.J.; Arbeitsgruppe Workflow Diagnostik und Therapie von Lebermetastasen kolorektaler Karzinome. Diagnosis and treatment of colorectal liver metastases. Work flow. Zentr. Bl. Chir. 2008; 133: 267–269.
  13. Yamakawa K., Yoshioka A., Shimizu K., Sakamaki T. Laparoechography: An ultrasonic diagnosis under laparoscopic observation. Japanese Journal of Medical Ultrasound Technology. 1964; 2: 26.
  14. Gavrilin A.V. Percutaneous therapeutic and diagnostic interventions under the control of ultrasound in surgical diseases of the organs of the hepatopancreatobiliary zone. Diss. … doct. of med. scien., - M., 1999; 443 p. (In Russ.)
  15. Beller S., Hünerbein M., Eulenstein S., Lange T., Schlag P.M. Feasibility of navigated resection of liver tumors using multiplanar visualization of intraoperative 3-dimensional ultrasound data. Ann Surg. 2007 Aug; 246(2): 288-294. doi: 10.1097/01.sla.0000264233.48306.99.
  16. Zhao A.V. Tumors of the liver and proximal bile ducts. Diss. … doc. of med. scien., - M., 1999; 158 p. (In Russ.)
  17. Efanov M.G. Segmental resections in focal liver lesions. Diss. … doc. of med. scien.,- M., 2010; 333 p. (In Russ.)
  18. Ionkin D.A., Zhavoronkova O.I., Stepanova Yu.A., Gavrilov Ya.Ya., Vishnevsky V.A., Zhao A.V. Thermal methods of local destruction (RFA, cryodestruction, MVA) in metastatic colorectal liver cancer. Postgraduate Bulletin of the Volga Region. 2018; 5-6 (Medicine): 127-145. (In Russ.) doi: 10.17816/2072-2354.2018.18.3.127-145
  19. Zhao A.V., Vishnevsky V.A., Ionkin D.A., Olifir A.A., Ayvazyan Kh.A., Kovalenko Yu.A., Zhavoronkova O.I., Stepanova Yu.A., Karelskaya N.A. The choice of method for local destruction of colorectal cancer metastases in the liver. Annals of HPB Surgery. 2019; 24(4): 30-36. (In Russ.) doi: 10.16931/1995-5464.2019430-36
  20. Sherlock S., Dooley J. Diseases of the liver and biliary tract. Practical guide: transl. germ. Ed. Aprosina Z.G., Mukhina N.A., Moscow: Geotar-Media, 1999; 864 p. (In Russ.)
  21. Stepanova Yu.A. Ultrasonic diagnosis of liver diseases (textbook). Edited by Corr. RAS L.S. Kokov. Ed. 3rd, add. and reworked. – M.: 11th format, 2018; 164 p. (In Russ.)
  22. Rykhtik P.I., Ryabova E.N., Safonov D.V., Kuchin D.M., Zagainov V.E., Romanov S.V. The value of intraoperative ultrasound in liver surgery. Radiology - Practice. 2016; 5(59): 16-25. (In Russ.)
  23. Machi J., Isomoto H., Kurohiji T., Yamashita Y., Shirouzu K., Kakegawa T., Sigel B., Zaren H.A., Sariego J. Accuracy of intraoperative ultrasonography in diagnosing liver metastasis from colorectal cancer: evaluation with postoperative follow-up results. World J Surg. 1991 Jul-Aug; 15(4): 551-556. doi: 10.1007/BF01675662.
  24. Friedrich-Rust M., Klopffleisch T., Nierhoff J., Herrmann E., Vermehren J., Schneider M.D., Zeuzem S., Bojunga J. Contrast-Enhanced Ultrasound for the differentiation of benign and malignant focal liver lesions: a meta-analysis. Liver Int. 2013 May; 33(5): 739-755. doi: 10.1111/liv.12115
  25. Focal Liver Lesions: Detection, Characterization, Ablation. Eds. R. Lencioni, D. Cioni, C. Bartolozzi. Springer-Verlag Berlin Heidelberg. 2005; 407 p.
  26. Fomina S.V. Ultrasound examination of the liver using echocontrast preparations based on sulfur hexafluoride. Diss. … cand. of. med. sciens. - Tomsk, 2017; 115 p. (In Russ.)
  27. Sporea I., Badea R., Popescu A., Spârchez Z., Sirli R.L., Dănilă M., Săndulescu L., Bota S., Calescu D.P., Nedelcu D., Brisc C., Ciobâca L., Gheorghe L., Socaciu M., Martie A., Ioaniţescu S., Tamas A., Streba C.T., Iordache M., Simionov I., Jinga M., Anghel A., Cijevschi Prelipcean C., Mihai C., Stanciu S.M., Stoicescu D., Dumitru E., Pietrareanu C., Bartos D., Manzat Saplacan R., Pârvulescu I., Vădan R., Smira G., Tuţă L., Săftoiu A. Contrast-enhanced ultrasound (CEUS) for the evaluation of focal liver lesions - a prospective multicenter study of its usefulness in clinical practice. Ultraschall Med. 2014 Jun; 35(3): 259-266. doi: 10.1055/s-0033-1355728
  28. Ooi C.C., Low S.C., Schneider-Kolsky M., Lombardo P., Lim S.Y., Abu Bakar R., Lo R.H. Diagnostic accuracy of contrast-enhanced ultrasound in differentiating benign and malignant focal liver lesions: a retrospective study. J Med Imaging Radiat Oncol. 2010; 54: 421–430. doi: 10.1111/j.1754-9485.2010.02195.x
  29. Guang Y., Xie L., Ding H., Cai A., Huang Y. Diagnosis value of focal liver lesions with SonoVue®-enhanced ultrasound compared with contrast-enhanced computed tomography and contrast-enhanced MRI: a meta-analysis. J Cancer Res Clin Oncol. 2011 Nov; 137(11): 1595-1605. doi: 10.1007/s00432-011-1035-8
  30. Cho S.H., Lee J.Y., Han J.K., Choi B.I. Acoustic radiation force impulse elastography for the evaluation of focal solid hepatic lesions: preliminary findings. Ultrasound Med Biol. 2010 Feb; 36(2): 202-208. doi: 10.1016/j.ultrasmedbio.2009.10.009
  31. Kim J.E., Lee J.Y., Bae K.S., Han J.K., Choi B.I. Acoustic radiation force impulse elastography for focal hepatic tumors: usefulness for differentiating hemangiomas from malignant tumors. Korean J Radiol. 2013 Sep-Oct; 14(5): 743-753. doi: 10.3348/kjr.2013.14.5.743
  32. Guibal A., Boularan C., Bruce M., Vallin M., Pilleul F., Walter T., Scoazec J.Y., Boublay N., Dumortier J., Lefort T. Evaluation of shearwave elastography for the characterisation of focal liver lesions on ultrasound. Eur Radiol. 2013 Apr; 23(4): 1138-1149. doi: 10.1007/s00330-012-2692-y
  33. Kato K., Sugimoto H., Kanazumi N., Nomoto S., Takeda S., Nakao A. Intra-operative application of real-time tissue elastography for the diagnosis of liver tumours. Liver Int. 2008 Nov; 28(9): 1264-1271. doi: 10.1111/j.1478-3231.2008.01701.x
  34. Inoue Y., Takahashi M., Arita J., Aoki T., Hasegawa K., Beck Y., Makuuchi M., Kokudo N. Intra-operative freehand real-time elastography for small focal liver lesions: "visual palpation" for non-palpable tumors. Surgery. 2010 Nov; 148(5): 1000-1011. doi: 10.1016/j.surg.2010.02.009
  35. Omichi K., Inoue Y., Hasegawa K., Sakamoto Y., Okinaga H., Aoki T., Sugawara Y., Kurahashi I., Kokudo N. Differential diagnosis of liver tumours using intraoperative realtime tissue elastography. Br J Surg. 2015; 102: 246-253. doi: 10.1002/bjs.9728
  36. Berdnikov S.N., Sholokhov V.N., Patyutko Yu.I., Makhotina M.S., Chuchuev E.S., Abirov K.E. Complex elastography (in manual compression mode and acoustic pulsed wave ARFI) and elastometry (SWV) in the differential diagnosis of hyperechoic liver lesions. SonoAce Ultrasound. 2013; 25: 56-63. (In Russ.)
  37. Nightingale K., McAleavey S., Trahey G. Shear-wave generation using acoustic radiation force: in vivo and ex vivo results. Ultrasound Med Biol. 2003 Dec; 29(12): 1715-1723. doi: 10.1016/j.ultrasmedbio.2003.08.008.
  38. Bogdanovich B.B., Begun I.V., Kondratenko G.G., Leonovich S.I. Instructions for the clinical use of intraoperative ultrasound in surgical gastroenterology. Registration number 111–1104. - Minsk, 2005; 9 p. (In Russ.)
  39. Bartoș A., Iancu I., Breazu C., Bartoș D. Intraoperative Ultrasound of the Liver: Actual Status and Indications. In book: Liver Research and Clinical Management. Ed. by Luis Rodrigo. – London: IntechOpen, 2018; 248 p.
  40. Torzillia G., Boteaa F., Procopioa F., Donadona M., Balzarinib L., Lutmanb F., Calliadac F., Montorsia M. Use of contrast-enhanced intraoperative ultrasonography during liver surgery for colorectal cancer liver metastases - Its impact on operative outcome. Analysis of a prospective cohort study. European journal of cancer. 2008; 6: 16–23. doi: 10.1016/j.ejcsup.2008.06.004
  41. Kim H.O., Kim S.K., Son B.H., Yoo C.H., Hong H.P., Cho Y.K., Kim B.I. Intraoperative radiofrequency ablation with or without tumorectomy for hepatocellular carcinoma in locations difficult for a percutaneous approach. Hepatobiliary Pancreat Dis Int. 2009 Dec; 8: 591–596.
  42. Joo I. The role of intraoperative ultrasonography in the diagnosis and management of focal hepatic lesions. Ultrasonography. 2015 Oct; 34(4): 246-257.
  43. Marcal L.P., Patnana M., Bhosale P., Bedi D.G. Intraoperative abdominal ultrasound in oncologic imaging. World J Radiol. 2013; 5: 51–60. doi: 10.4329/wjr.v5.i3.51
  44. Kuntsevich G.I. Color Doppler scanning and 3D reconstruction of abdominal vessels. In book. Doppler ultrasound diagnostics in the clinic. Ed. Nikitin Yu.M., Trukhanov A.I. - Ivanovo: MIK, 2004; 301-325. (In Russ.)
  45. Alempijević T., Kovacević N., Tomić D., Duranović S., Krstić M. Significance of color Doppler ultrasonography in the assessment of pancreatic carcinoma vascular invasion. // Vojnosanit Pregl. 2006 Oct; 63(10): 857-860. doi: 10.2298/vsp0610857a.
  46. Zacherl J., Scheuba C., Imhof M., Zacherl M., Langle F., Pokieser P., Wrba F., Wenzl E., Mtihlbacher F., Jakesz R., Steininger R. Current value of intraoperative sonography during surgery for hepatic neoplasms. World J Surg. 2002; 26: 550–554. doi: 10.1007/s00268-001-0266-2
  47. Hoch G., Croise-Laurent V., Germain A., Brunaud L., Bresler L., Ayav A. Is intraoperative ultrasound still useful for the detection of colorectal cancer liver metastases? HPB. 2015; 17: 514–519. doi: 10.1111/hpb.12393
  48. Solomon M.J., Stephen M.S., Gallinger S., White G.H. Does intraoperative hepatic ultrasonography change surgical decision making during liver resection? Am J Surg. 1994; 168: 307–310. doi: 10.1016/s0002-9610(05)80154-0
  49. Engstrand J., Nilsson H., Strömberg C., Jonas E., Freedman J. Colorectal cancer liver metastases – a population-based study on incidence, management and survival. BMC Cancer. 2018; 18: 78. doi: 10.1186/s12885-017-3925-x
  50. Donadon M., Torzilli G. Intraoperative ultrasound in patients with hepatocellular carcinoma: from daily practice to future trends. Liver Cancer. 2013 Jan; 2(1): 16-24. doi: 10.1159/000346421.
  51. Xiang C., Liu Z., Dong J., Sano K., Makuuchi M. Precise anatomical resection of the ventral part of Segment VIII. Int J Surg Case Rep. 2014; 5(12): 924-926. doi: 10.1016/j.ijscr.2014.10.041.
  52. Torzilli G., Procopio F., Costa G. Resection guidance. In: Torzilli G., editor. Ultrasound-Guided Liver Surgery. - Italia: Springer; 2014; 117-168.
  53. Machi J., Uchida S., Sumida K., Limm W.M., Hundahl S.A., Oishi A.J., Furumoto N.L., Oishi R.H. Ultrasound-guided radiofrequency thermal ablation of liver tumors: percutaneous, laparoscopic, and open surgical approaches. J Gastrointest Surg. 2001; 5: 477-489. doi: 10.1016/s1091-255x(01)80085-8
  54. Ishiko T., Beppu T., Sugiyama S., Masuda T., Takahashi M., Komori H., Takamori H., Hirota M., Kanemitu K., Baba H. Radiofrequency ablation with hand-assisted laparoscopic surgery for the treatment of hepatocellular carcinoma in the caudate lobe. Surg Laparosc Endosc Percutan Tech. 2008; 18: 272–276. doi: 10.1097/SLE.0b013e31816a24bf
  55. El-Gendi A., El-Shafei M., Abdel-Aziz F., Bedewy E. Intraoperative ablation for small HCC not amenable for percutaneous radiofrequency ablation in Child A cirrhotic patients. J Gastrointest Surg. 2013; 17: 712-718. doi: 10.1007/s11605-012-2085-1
  56. Cheung T.T., Ng K.K., Chok K.S., Chan S.C., Poon R.T., Lo C.M., Fan S.T. Combined resection and radiofrequency ablation for multifocal hepatocellular carcinoma: prognosis and outcomes. World J Gastroenterol. 2010; 16: 3056-3062. doi: 10.3748/WJG.V16.I24.3056
  57. Kosyrev V.Yu. Radiofrequency thermal ablation in the combined treatment of malignant liver tumors (indications, methodology, results of treatment. Diss. ... of med. scien- M., 2011; 234 p. (In Russ.)
  58. Sergeeva O.N. Radiofrequency ablation in focal liver lesions. Diss. ... cand. of med. scien. - M., 2005; 131 p. (In Russ.)
  59. Zhavoronkova O.I., Melekhina O.I., Ionkin D.A., Shurakova A.B., Stepanova Yu.A., Karmazanovsky G.G., Vishnevsky V.A. Experience in the use of radiofrequency thermal ablation for liver metastases of colorectal cancer. Coloproctology. 2014; 1(47) (supplement): 27-36. (In Russ.)
  60. Ionkin D.A., Stepanova Yu.A., Zhavoronkova O.I., Bugaev S.A., Zhao A.V. Radiofrequency ablation of focal liver tumors. Textbook. - M .: 11th format, 2021; 128 p. (In Russ.)
  61. Sun Y., Cheng Z., Dong L., Zhang G., Wang Y., Liang P. Comparison of temperature curve and ablation zone between 915- and 2450-MHz cooled-shaft microwave antenna:results in ex vivo porcine livers. Eur J Radiol. 2012; 81: 553–557. doi: 10.1016/j.ejrad.2011.02.013
  62. Moskvicheva L.I., Sidorov D.V., Lozhkin M.V., Petrov L.O., Zabelin M.V. Modern methods of ablation of malignant neoplasms of the liver. Research and practice in medicine. 2018; 5(4): 58-71. (In Russ.)
  63. Claudon M., Dietrich C.F., Choi B.I., Cosgrove D.O., Kudo M., Nolsøe C.P., Piscaglia F., Wilson S.R., Barr R.G., Chammas M.C., Chaubal N.G., Chen M.H., Clevert D.A., Correas J.M., Ding H., Forsberg F., Fowlkes J.B., Gibson R.N., Goldberg B.B., Lassau N., Leen E.L., Mattrey R.F., Moriyasu F., Solbiati L., Weskott H.P., Xu H.X. .Guidelines and good clinical practice recommendations for Contrast Enhanced Ultrasound (CEUS) in the liver - update 2012: a WFUMB-EFSUMB initiative in cooperation with representatives of AFSUMB, AIUM, ASUM, FLAUS and ICUS. Ultrasound. Med Biol. 2013; 39: 187–210. doi: 10.1055/s-0032-1325499
  64. Xu E.-J., Lv S.-M., Li K., Long Y.-L., Zeng Q.-J., Su Z.-Z., Zheng R.-Q. Immediate evaluation and guidance of liver cancer thermal ablation by three-dimensional ultrasound/contrast-enhanced ultrasound fusion imaging, International Journal of Hyperthermia. 2018; 34(6): 870-876. doi: 10.1080/02656736.2017.1373306
  65. Mariani A., Kwiecinski W., Pernot M., Balvay D., Tanter M., Clement O., Cuenod C.A., Zinzindohoue F. Real time shear waves elastography monitoring of thermal ablation: in vivo evaluation in pig livers. J Surg Res. 2014; 188: 37-43. doi: 10.1016/j.jss.2013.12.024
  66. Van Vledder M.G., Boctor E.M., Assumpcao L.R., Rivaz H., Foroughi P., Hager G.D., Hamper U.M., Pawlik T.M., Choti M.A. Intra-operative ultrasound elasticity imaging for monitoring of hepatic tumour thermal ablation. HPB (Oxford). 2010 Dec; 12(10): 717-723. doi: 10.1111/j.1477-2574.2010.00247.x
  67. Correa-Gallego C., Karkar A.M., Monette S., Ezell P.C., Jarnagin W.R., Kingham T.P. Intraoperative ultrasound and tissue elastography measurements do not predict the size of hepatic microwave ablations. Acad Radiol. 2014; 21: 72-78. doi: 10.1016/j.acra.2013.09.022
  68. Foley E.F., Kolecki R.V., Schirmer B.D. The accuracy of laparoscopic ultrasound in the detection of colorectal cancer liver metastases. Am J Surg. 1998; 176(3): 262-264. doi: 10.1016/s0002-9610(98)00147-0

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