Reactive changes in the neutrophilic bone marrow growth during the recovery period after parenchymal bleeding from the liver

Background. Traumatic liver injury often leads to a serious condition of the patient with a high probability of death. In the surgeon’s arsenal, local hemostatic agents occupy a leading place in parenchymal bleeding. However, there is no single medication that is reliable, effective, and safe. The purpose of the research was to study the nature of reactive changes on the part of the neutrophilic bone marrow germ in the recovery period after liver parenchymal bleeding when using a hemostatic collagen preparation. Materials and methods. An experimental study was conducted on 72 outbred rats. Two groups were identified: the control group (n = 19) and the experimental group (n = 53), in which parenchymal bleeding was simulated and hemostasis was achieved by pressing a collagen hemostatic sponge made of reindeer skin. Quantitative indicators of red bone marrow were studied in both groups. On days 3, 7, 14, and 21, laboratory animals were removed from the experiment, and bone marrow was collected for cytological examination. Results. In the recovery period after parenchymal bleeding of the liver, a statistically significant decrease in the content of neutrophilic myelocytes was recorded in the myelogram, and reactive changes were characterized by the prevalence of differentiation processes over proliferation processes, which was indicated by the accumulation of metamyelocytes and an increase in the content of rod-shaped neutrophils throughout the experiment. Conclusion. In the recovery period, the reactive changes in the neutrophilic link of the bone marrow consisted in the predominance of the processes of differentiation of neutrophilic myelocytes into metamyelocytes and rod-shaped neutrophils.