Review of modern world experience of using ozone therapy in dermatology
- 作者: Kosheleva I.V.1, Bitkina O.A.2, Pershina K.S.2, Kontorshchikova K.N.2,3, Bitkina E.V.4
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隶属关系:
- Russian Medical Academy of Continuous Professional Education
- Privolzhsky Research Medical University
- National Research State University of Nizhny Novgorod n.a. N.I. Lobachevsky
- Peoples’ Friendship University of Russia n.a. Patrice Lumumba
- 期: 卷 31, 编号 5 (2024)
- 页面: 46-52
- 栏目: Reviews
- URL: https://journal-vniispk.ru/2073-4034/article/view/267798
- DOI: https://doi.org/10.18565/pharmateca.2024.5.46-52
- ID: 267798
如何引用文章
详细
The article is devoted to the description of the use of ozone therapy as a physiotherapeutic method in the complex therapy of dermatoses, the analysis of modern domestic and foreign publications revealing the therapeutic possibilities of ozone therapy methods in the treatment of dermatoses. The use of new topical preparations based on ozonized olive oil is covered. The article also provides information on possible options for the combined use of ozone and laser therapy.
作者简介
I. Kosheleva
Russian Medical Academy of Continuous Professional Education
Email: kris.tina1300@mail.ru
ORCID iD: 0000-0003-2767-3021
俄罗斯联邦, Moscow
O. Bitkina
Privolzhsky Research Medical University
Email: kris.tina1300@mail.ru
ORCID iD: 0000-0003-4993-3269
俄罗斯联邦, Nizhny Novgorod
K. Pershina
Privolzhsky Research Medical University
编辑信件的主要联系方式.
Email: kris.tina1300@mail.ru
ORCID iD: 0009-0003-4362-9618
PhD student, Department of Skin and Venereal Diseases
俄罗斯联邦, Nizhny NovgorodK. Kontorshchikova
Privolzhsky Research Medical University; National Research State University of Nizhny Novgorod n.a. N.I. Lobachevsky
Email: kris.tina1300@mail.ru
ORCID iD: 0000-0001-8345-9359
俄罗斯联邦, Nizhny Novgorod; Nizhny Novgorod
E. Bitkina
Peoples’ Friendship University of Russia n.a. Patrice Lumumba
Email: kris.tina1300@mail.ru
ORCID iD: 0009-0009-3175-0836
俄罗斯联邦, Moscow
参考
- Назаров Е.И., Якимов С.В. Медицинские газы. Различия и единство терапевтического действия озона, ксенона и водорода. Издание первое. Одесса, 2016. 233 с. [Nazarov E.I., Yakimov S.V. Medical gases. Differences and unity of the therapeutic action of ozone, xenon and hydrogen. First edition. Odessa, 2016. 233 p. (In Russ.)].
- Масленников О.В., Конторщикова К.Н., Шахов Б.Е. Руководство по озонотерапии. Издание четвертое. Нижний Новгород, 2016. 346 с. [Maslennikov O.V., Kontorshchikova K.N., Shakhov B.E. Handbook of ozone therapy. Fourth edition. Nizhny Novgorod, 2016. 346 p. (In Russ.)].
- Elvis A.M., Ekta J.S. Ozone therapy: A clinical review. J Nat Sci Biol Med. 2011 Jan;2(1):66–70. doi: 10.4103/0976-9668.82319.
- Smith N.L., Wilson A.L., Gandhi J., et al. Ozone therapy: an overview of pharmacodynamics, current research, and clinical utility. Med Gas Res. 2017 Oct 17;7(3):212–19. doi: 10.4103/2045-9912.215752.
- Valacchi G., Sticozzi C., Zanardi I., et al. Ozone mediators effect on “in vitro” scratch wound closure. Free Radical Research. 2016;50(9):1022–31. doi: 10.1080/10715762.2016.1219731.
- Di Mauro R., Cantarella G., Bernardini R., et al. The biochemical and pharmacological properties of ozone: The smell of protection in acute and chronic diseases. Int J Mol Sci. 2019;20:634. doi: 10.3390/ijms20030634.
- Delgado R.L., Tamargo S.B., Takon O.G., Polo V.J.C. Medical ozone increases methotrexate clinical response and improves cellular redox balance in patients with rheumatoid arthritis. Eur J Pharmacol. 2016;789:313–18. doi: 10.1016/j.ejphar.2016.07.031.
- Takon O.G., Viebahn-Haensler R., Lуpez C.G., et al. Medical Ozone Reduces the Risk of GGT and Alkaline Phosphatase Abnormalities and Oxidative Stress in Rheumatoid Arthritis Patients treated with Methotrexate. SMJ. Arthritis Res. 2017;1:1004.
- Nowicka D. Thermography improves clinical assessment in patients with systemic sclerosis treated with ozone therapy. Biomed Res Int. 2017;2017:5842723. doi: 10.1155/2017/5842723.
- Конторщикова К.И., Обухов Л.И., Сибиркин А.Л. Молекулярные продукты разложения озона в водных растворах. Биорадикалы и Антиоксиданты. 2015;31(2):45–53. [Kontorshchikova K.I., Obukhov L.I., Sibirkin A.L. Molecular products of ozone decomposition in aqueous solutions. Bioradikaly i Antioksidanty. 2015;31(2):45–53. (In Russ.)].
- Zeng J., Lu J. Mechanisms of action involved in ozone-therapy in skin diseases. Int Immunopharmacol. 2018;56(138):235–41. doi: 10.1016/j.intimp.2018.01.040.
- Suh Y., Patel S., Kaitlyn R., et al. Clinical utility of ozone therapy in dental and oral medicine. Med Gas Res. 2019;9(3):163–67. doi: 10.4103/2045-9912.266997.
- Галеева Н.В., Фазылов В.Х., Валеева И.Х. Патогенетическое значение оксида азота и процессов перекисного окисления липидов при естественном течении HCV-инфекции и на фоне озонотерапии. Практическая медицина. 2014;7(83):99–103. [Galeeva N.V., Fazylov V.Kh., Valeeva I.Kh. Pathogenetic significance of nitric oxide and lipid peroxidation processes in the natural course of HCV infection and during ozone therapy. Prakticheskaya meditsina. 2014;7(83):99–103 (In Russ.)].
- Щербатюк Т.Г. Современное состояние озонотерапии в медицине. Перспективы применения в онкологии. Современные технологии в медицине. 2010;1:99–106. [Shcherbatyuk T.G. Current state of ozone therapy in medicine. Prospects for use in oncology. Sovremennye tekhnologii v meditsine. 2010;1:99–106. (In Russ.)].
- Фазылов В.Х., Галеева Н.В., Загидуллина А.И., Таиров И.Н. Озонотерапия в клинике инфекционных болезней. Практическая медицина. 2013:5:47–51. [Fazylov V.Kh., Galeeva N.V., Zagidullina A.I., Tairov I.N. Ozone therapy in the clinic of infectious diseases. Prakticheskaya meditsina. 2013:5:47–51. (In Russ.)].
- Баранова И.В. Функциональное состояние суставов как критерий оценки эффективности использования озонотерапии в восстановительном лечении больных гонартрозом. Вопросы курортологии, физиотерапии и лечебной физической культуры. 2018;95(3):42–48. [Baranova I. The use of the functional state of the joints for the estimation of the effectiveness of the application of oxygen/ozone therapy for the rehabilitative treatment of the patients suffering from knee arthritis. Voprosy kurortologii, fizioterapii i lechebnoi fizicheskoi kul’tury. 2018;95(3):42–8. (In Russ.)].
- Gupta A.K., Brintnell W. Ozone gas effectively kills laboratory strains of Trichophyton rubrum and Trichophyton mentagrophytes using an in vitro test system. J Dermatol Treat. 2014 Jun;25(3):251–55. doi: 10.3109/09546634.2012.714456.
- Lu J., Guo M., Ligui H., et al Efficacy of combination of ozonated water with oil for treatment of tinea pedis. Zhong Nan Da Xue XueBao Yi Xue Ban. 2018 Feb 28;43(2):147–51.
- Tara F., Zand-Kargar Z., Rajabi O., et al. The Effects of Ozonated Olive Oil and Clotrimazole Cream for Treatment of Vulvovaginal Candidiasis. Alternative therapies in health and medicine. 2016 Jul;22(4):44–9.
- Титова Г.В., Добрякова Э.А. Опыт сочетанного применения озонотерапии и плазмафереза у больных с актиномикозом мягких тканей и суппуративным гидраденитом различных локализаций в хирургическом стационаре. Вестник физиотерапии и курортологии. 2016;22(2):50–58. [Titova G.V., Dobryakova E.A. Experience of combined use of ozone therapy and plasmapheresis in patients with actinomycosis of soft tissues and suppurative hidradenitis of various localizations in a surgical hospital. Vestnik fizioterapii i kurortologii. 2016;22(2):50–58. (In Russ.)].
- Wang X. Emerging roles of ozone in skin diseases. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2018;43(2):114–23.
- Huang J., Huang J., Xiang Y., et al. Topical ozone therapy: an innovative solution to patients with herpes zoster [in Chinese]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2018;43(2):168–72.
- Разумовский А.В., Курников Г.Ю., Радовская Е.В. Эффективность озонотерапии в дерматологической практике. Биорадикалы и Антиоксиданты. 2016;3(3):127–28. [Razumovsky A.V., Kurnikov G.Yu., Radovskaya E.V. Efficiency of ozone therapy in dermatological practice. Bioradikaly i Antioksidanty. 2016;3(3):127–28. (In Russ.)].
- Кошелева И.В., Симонова А.В. Озонотерапия в лечении иммунозависимых дерматозов. Физиотерапия, бальнеология и реабилитация. 2013;2:14–20. [Kosheleva I.V., Simonova A.V. Ozone therapy in the treatment of immune-dependent dermatoses. Fizioterapiya, bal’neologiya i reabilitatsiya. 2013;2:14–20. (In Russ.)].
- Елистратова И.В., Морозов С.Г., Захарова И.А. Изменение фагоцитарной активности и продукции активных форм кислорода нейтрофилами периферической крови больных атопическим дерматитом в зависимости от стадии заболевания. Санкт-Петербургские дерматологические чтения: сборник тезисов X Научно-практической конференции дерматовенерологов и косметологов. Под ред. проф. Самцова А.В., проф. Соколовского Е.В., проф. Разнатовского К.И. СПб.: Изд-во «Человек и его здоровье», 2016. С. 27–8. [Elistratova I.V., Morozov S.G., Zakharova I.A. Changes in phagocytic activity and production of reactive oxygen species by peripheral blood neutrophils in patients with atopic dermatitis depending on the stage of the disease. St. Petersburg Dermatological Readings: Collection of Abstracts of the 10th Scientific and Practical Conference of Dermatovenerologists and Cosmetologists. Edited by prof. Samtsov A.V., prof. Sokolovsky E.V., prof. Raznatovsky K.I. St. Petersburg: Man and His Health Publishing House, 2016. P. 27–8. (In Russ.)].
- Суслова Е.В., Суетина И.Г., Хлебникова Н.В., Иллек Я.Ю. Влияние озонотерапии на неспецифический противомикробный иммунитет у детей с атопическим дерматитом. Вятский медицинский вестник. 2020;3(67):35–7. [Suslova E.V., Suetina I.G., Khlebnikova N.V., Illek Ya.Yu. The effect of ozone therapy on nonspecific antimicrobial immunity in children with atopic dermatitis. Vyatskiy meditsinskiy vestnik. 2020;3(67):35–7. (In Russ.)].
- Zeng J., Dou J., Gao L., et al. Topical ozone therapy restores microbiome diversity in atopic dermatitis. Int Immunopharmacol. 2020;80:106191. doi: 10.1016/j.intimp.2020.106191.
- Qin G., Huang J., Pan Y., et al. Topical ozone application: an innovative therapy for infantile atopic dermatitis [in Chinese]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2018;43(2):163–67.
- Lu J., Li M., Huang J., et al. Effect of ozone on Staphylococcus aureus colonization in patients with atopic dermatitis [in Chinese]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2018;43(2):157–62.
- Oliveira Modena D.A., Castro Ferreira R., Froes P.M., Rocha K.C. Ozone therapy for dermatological conditions: a systematic review. J Clin Aesthet Dermatol. 2022;15(5):65–73.
- Travagli V., Lorio E. L. The biological and molecular action of ozone and its derivates: state-of-the-art, enhanced scenarios, and quality insights. Int J Mol Sci. 2023;24:8465. doi: 10.3390/ijms24108465.
- Liu L., Zeng L., Gao L., et al. Ozone therapy for skin diseases: cellular and molecular mechanisms. Int Wound J. 2022:1–10.
- Зубарева Т.С., Максимова М.Д. Эффективность применения озонотерапии в лечении трофических нарушений кожи. Санкт-Петербургские дерматологические чтения: сборник тезисов XI Научно-практической конференции дерматовенерологов и косметологов. Под ред. проф. Самцова А.В., проф. Соколовского Е.В., проф. Разнатовского К.И. СПб.: Изд-во «Человек и его здоровье», 2017. С. 31–3. [Zubareva T.S., Maksimova M.D. Efficiency of ozone therapy in the treatment of trophic skin disorders. St. Petersburg dermatological readings: collection of abstracts of the XI Scientific and practical conference of dermatovenerologists and cosmetologists. Edited by prof. Samtsov A.V., prof. Sokolovsky E.V., prof. Raznatovsky K.I. St. Petersburg: Publishing house «Chelovek i ego zdorovie», 2017. P. 31–3. (In Russ.)].
- Kadir K., Syam Y., Yusuf S., Zainuddin M. Ozone therapy on reduction of bacterial colonies and acceleration of diabetic foot ulcer healing. Home Healthc Now. 2020;38(4):215–20. doi: 10.1097/NHH.0000000000000889.
- Modena O.A.D., Miranda G.C.A., Grecco C., et al. Efficacy and safety of ND: YAG 1064 nm lasers for photoepilation: a systematic review. Lasers Med Sci. 2020;35(4):797–806. doi: 10.1007/s10103-019-02939-6.
- Izadi M., Kheirjou R., Mohammadpour R. Efficacy of comprehensive ozone therapy in diabetic foot ulcer healing. Diabetes Metab Syndr. 2019;13(1):822–25. doi: 10.1016/j.dsx.2018.11.060.
- Jiang F., Deng D., Li X., et al. Curative effect of ozone hydrotherapy for pemphigus. Zhong nan da xue xue bao Yi Xue ban=J centr South Univ Med Sci. 2018;43(2):152–56.
- Rowen R.J. Remission of aggressive autoimmune disease (dermatomyositis) with removal of infective jaw pathology and ozone therapy: review and case report. Autoimmunity High-lights. 2018;9(1):7.
- Patel P.V., Kumar V., Kumar S., et al. Therapeutical effect of topical ozonited oil on the epithelial healing of palatal wound sites: a planimetrcal and cytological study. J Investig Clin Dent. 2021;2(4):248–58. doi: 10.1111/j.2041-1626.2011.00072.x.
- Fernandez J., Del Valle Fernandez, Villar C.J., Lombo F. Combined laser and ozone therapy for onyhomycosis in an in vitro and ex vivo model. PLOS ONE. 2021;16(6):e0253979. doi: 10.1371/journal.pone.0253979.
- Zeng J., Lei L., Zeng Q. Ozone therapy attenuates NK-kB-Mediated local Inflammatory response and activation of Th17 cells in treatment for psoriasis. Int J Biol Sci. 2020;16(11):1833–45. doi: 10.7150/ijbs.41940.
- Zeng J., Dou J., Gao L., et al. International Immunopharmacology Topical ozone therapy restores microbiome diversity in atopic dermatitis. Int Immunopharmacol. 2020;80:106191.
- Song M., Zeng Q., Xiang Y., et al. The antibacterial effect of topical ozone on the treatment of MRSA skin infection. Mol Med Rep. 2018:17(2):2449–55. doi: 10.3892/mmr.2017.8148.
- Ouf S.A., Moussa T.A., Abd-Elmegeed A.M., Eltahlawy S. R. Ozone against some dermatophytes. Braz J Microbiol. 2016;47(3):697–702. doi: 10.1016/j.bjm.2016.04.014.
- Tan L., Jian Huang J., Lu J., et al. Clinical efficacy of ozonated oil in the treatment of psoriasis vulgaris [in Chinese]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2018;43(2):173–78.
- Gao L., Dou J., Zhang B., et al. Ozone therapy promotes the differentiation of basal keratinocytes via increasing Tp63-mediated transcription of KRT10 to improve psoriasis. J Cell Mol Med. 2020 Apr;24(8):4819–29. doi: 10.1111/jcmm.15160.
- Aghaei M., Nilfoushzadeh M.A., Aghaei S., et al. Two cases of Rosacea treated with topical ozonate olive oil. Dermatol Clin Res. 2017;(3(1):151–54.
- Биткина О., Копытова Т., Конторщикова К., Баврина А. Уровень оксидантного стресса у больных розацеа и обоснование лечебного применения озоно-кислородной смеси. Клиническая лабораторная диагностика. 2010;4:13–6. [Bitkina O., Kopytova T., Kontorshchikova K., Bavrina A. Oxidative stress level in patients with rosacea and a rationale for the therapeutic use of an ozone-oxygen mixture. Klinicheskaia laboratornaia diagnostika. 2010;4:13–6. (In Russ.)].
- Жуков В.В., Письменский А.В., Кожин А.А. Комплексная озоно-лазерная терапия больных нейродермитом. Лазерная медицина. 2018;22(1). [Zhukov V.V., Pismensky A.V., Kozhin A.A. Complex ozone-laser therapy of patients with neurodermatitis. Lazernaya meditsina. 2018;22(1). (In Russ.)].
- Патент «Способ лечения нейродермита» RU2269347C1. [Patent “Method for treating neurodermatitis” RU2269347C1. (In Russ.)].
- Kazancioglu H.O., Erisen M. Comparison of low-level laser therapy versus ozone therapy in the treatment of oral lichen planus. Ann Dermatol. 2015;27(5):485–91. doi: 10.5021/ad.2015.27.5.485
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