Bite pathology in patients with signs of undifferentiated connective tissue dysplasia (UCTD). Possibilities of aesthetic correction of changes in the lower third of the face in patients with UCTD after orthodontic treatment
- Authors: Svechnikova E.V.1,2, Arutyunyan G.B.3, Artemyeva N.O.4, Morzhanaeva M.A.5, Terentyeva L.V.3, Devyatova A.V.4, Nelga I.O.4, Rzhevskaya E.V.2, Shcheglyuk D.Y.4
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Affiliations:
- Russian Biotechnology University
- Polyclinic №1 of the Administrative Directorate of the President of the Russian Federation
- Pirogov Russian National Research Medical University
- Expert Multidisciplinary Clinic OMNIUS
- Beauty Expert Medical
- Issue: Vol 32, No 5 (2025)
- Pages: 60-67
- Section: Original articles
- URL: https://journal-vniispk.ru/2073-4034/article/view/316493
- DOI: https://doi.org/10.18565/pharmateca.2025.5.60-67
- ID: 316493
Cite item
Abstract
Background: The possibilities of modern medicine allow to improve the appearance of a person’s face without resorting to radical surgical interventions. One of the frequent requests in the practice of a cosmetologist is the elimination of aesthetic problems that patients experience after completing orthodontic correction of the dentoalveolar system. As a rule, this changes the volume of soft tissues of the lower third of the face, hypertonicity of the masticatory muscles occurs, nasolabial folds increase, patients note skeletonization of the face, a change in the oval – a feeling of an “aging” face appears. And, of course, these changes cause psychological discomfort to the patient.
Objective: Determination of the incidence of bite pathology in patients with signs of undifferentiated connective tissue dysplasia (UCTD) and the presence of polymorphisms of the genes responsible for the synthesis of collagen and elastin.
Materials and methods: The pilot study involved 71 patients. All patients underwent genetic testing, questionnaires on the presence of phenotypic features of UCTD, assessment of the risk of UCTD and bite pathology.
Results:
- The results of the study show that the study groups have significant differences in the presence of bite pathology, which is confirmed by low p values for most of the analyzed markers. Particularly pronounced differences were observed for the genetic markers rs7787362_ELN and risk, which may indicate their importance in predicting bite pathology. Significant differences were also found for the marker rs1800012_COL1A1, which may indicate its role in this pathology.
- Patients without bite pathology have significantly higher chances of having the rs1800012_COL1A1_CC and rs7787362_ELN_TT genotypes. Patients with bite pathology more often have rs7787362_ELN_CC genotypes, a high risk according to the questionnaire. These data highlight the importance of genetic testing for assessing the risk of developing bite pathology and may help in developing individualized approaches to treatment and prevention.
- Patients with bite pathology malocclusion (group 1) have significantly higher scores on the questionnaire (15.0 [13.0; 16.0]) compared to patients without pathology (group 0, 10.0 [8.0; 10.0]). This indicates that the presence of bite pathology was associated with higher values in the questionnaire, which may reflect more pronounced clinical or demographic features in this group.
- The conducted correlation analysis showed that there was a significant correlation between bite pathology and undifferentiated connective tissue dysplasia (R=0.619; p<0.001*).
- Also, the presence of polymorphism in the rs7787362_ELN gene significantly increases the risk of bite pathology, while the rs1800012_COL1A1 and rs7787362_ELN genes with no polymorphisms have a protective value in predicting the absence of bite pathology.
Conclusion: Modern achievements in aesthetic medicine make it possible to effectively correct changes that occur during or as a result of orthodontic correction, which can cause psychological discomfort in the patient. Interdisciplinary interaction between orthodontists and cosmetologists will play a special role in the future. The authors believe that it is especially important to introduce aesthetic and functional prognosis into orthodontic practice in order to minimize aesthetic and psychological problems in patients.
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##article.viewOnOriginalSite##About the authors
Elena V. Svechnikova
Russian Biotechnology University; Polyclinic №1 of the Administrative Directorate of the President of the Russian Federation
Author for correspondence.
Email: elene-elene@bk.ru
ORCID iD: 0000-0002-5885-4872
Dr. Sci. (Med.), Professor, Department of Skin and Venereal Diseases; Head of the Department of Dermatovenereology and Cosmetology
Russian Federation, Moscow; MoscowGrigory B. Arutyunyan
Pirogov Russian National Research Medical University
Email: arutyunyan.g82@mail.ru
ORCID iD: 0000-0002-9454-0854
Senior Lecturer, Department of Dermatovenereology named after Academician Yu.K. Skripkin
Russian Federation, MoscowNatalia O. Artemyeva
Expert Multidisciplinary Clinic OMNIUS
Email: natalya.artemeva.89@mail.ru
ORCID iD: 0000-0002-5619-6757
Cand. Sci. (Med.), Nutritionist, Geneticist
Russian Federation, MoscowMaria A. Morzhanaeva
Beauty Expert Medical
Email: elene-elene@bk.ru
Cosmetologist, Medical Adviser
Russian FederationLada V. Terentyeva
Pirogov Russian National Research Medical University
Email: t.lada@inbox.ru
ORCID iD: 0000-0001-8562-1778
Cand. Sci. (Med.), Associate Professor, Department of Dermatovenereology named after Academician Yu.K. Skripkin ICM
Russian Federation, MoscowAlena V. Devyatova
Expert Multidisciplinary Clinic OMNIUS
Email: alyona9va@mail.ru
ORCID iD: 0000-0003-0498-2673
Dermatovenerologist
Russian Federation, MoscowIrina O. Nelga
Expert Multidisciplinary Clinic OMNIUS
Email: irinanelga@mail.ru
Dermatovenerologist, Cosmetologist, Trichologist
Russian Federation, MoscowElena V. Rzhevskaya
Polyclinic №1 of the Administrative Directorate of the President of the Russian Federation
Email: nolamz@mail.ru
Cand. Sci. (Med.), Chief Physician
Russian Federation, MoscowDenis Yu. Shcheglyuk
Expert Multidisciplinary Clinic OMNIUS
Email: sheglyuk85@mail.ru
Orthopedic dentist, General dentist, Dental surgeon
Russian Federation, MoscowReferences
- Аюпова Ф.С., Митропанова М.Н., Восканян А.Р. Классификация зубочелюстных аномалий. Современные методы диагностики в ортодонтии. Краснодар: КубГМУ, 2021. 120 с. [Ayupova F.S., Mitropanova M.N., Voskanyan A.R. Classification of dentoalveolar anomalies. Modern diagnostic methods in orthodontics. Krasnodar: KubSMU, 2021. 120 p. (In Russ.)].
- Налбандян М.С., Тер-Погосян Г.Ю., Есаян Л.К., Казарян Э.Р. Роль эстетики в современной ортодонтической диагностике и лечении. Проблемы стоматологии. 2018;14(3):86–90. [Nalbandyan M.S., Ter-Pogosyan G.Yu., Yesayan L.K., Kazaryan E.R. The role of aesthetics in modern orthodontic diagnostics and treatment. Problemy stomatologii. 2018;14(3):86–90. (In Russ.)].
- Петрова Н.П. Морфологические изменения слизистой оболочки десны на ранних этапах ортодонтического лечения. СПб.: Медицина, 2008. 136 c. [Petrova N.P. Morphological changes in the gingival mucosa at early stages of orthodontic treatment. SPb.: Meditsina, 2008. 136 p. (In Russ.)].
- Persicon A.V., Brodsky B. Unstable molecules form stable tissues. Proc. Natl. Acad. Sci. U S A 2012;99(3):1101–3. doi: 10.1073/pnas.042707899
- Кадурина Т.И., Аббакумова Л.Н. Принципы реабилитации больных с дисплазией соединительной ткани. Лечащий врач. 2010;40:10–16. [Kadurina T.I., Abbakumova L.N. Principles of rehabilitation of patients with connective tissue dysplasia. Lechashchiy vrach. 2010;40:10–16. (In Russ.)].
- Liu C., Du S., Wang Z., et al. Impact of ortho-dontic-induced facial morphology changes on aesthetic evaluation: a retrospective study BMC Oral Health. 2024;24(24). https://doi.org/10.1186/s12903-023-03776-4
- Janson G., Valarelli F.P., Henriques J.F. Soft-tissue changes in Class II malocclusion patients treated with extractions: a systematic review. Eur J Orthod. 2016;38(5):541–548.
- Konstantonis D., Alexandropoulos E., Makou M., Katsaros C. Effects of premolar extractions on the soft tissue profile: a systematic review. Eur J Oral Sci. 2018;126(2):96–106.
- Xu Y., Jin Z., Li J. Profiles of facial soft tissue changes during and after orthodontic treatment in female adults. BMC Oral Health. 2022; 22(1):145–152.
- Tran Cao P. The Use of Botulinum Toxin and Dermal Fillers to Enhance Patients’ Perceived Attractiveness. Dent Clin North Am. 2020; 64(4):659–668.
- Sonone T.P., Soni V., Gupta S. et al. Botox and Dermal Fillers in Orthodontics - A Review. J Pharm Bioallied Sci. 2022; 14(Suppl 1):S60–S64.
- Guo Y., Chang L., Zhou D. Treatment of Chin Retrusion With Botulinum Toxin Plus Hyaluronic Acid Filler vs Filler Alone: Randomized Study. Aesthet Surg J. 2024;44(5):537–544.
- Грязева Н.В., Гресь С.Н., Круглова Л.С. Безопасность и эффективность использования филлеров на основе гиалуроновой кислоты. Эффективная фармакотерапия. 2022;18(31):40–43. [Gryazeva N.V., Gres S.N., Kruglova L.S. Safety and Efficacy of Hyaluronic Acid Fillers in Terms of Evidence-Based Medicine. Effektivnaya farmakoterapiya. 2022;18(31):40–43. (In Russ.)]. https://dx.doi.org/10.33978/2307-3586-2022-18-31-40-43
- Jansma J., Schepers R.H. Adjunctive Aesthetic Procedures in Orthognathic Surgery. Oral Maxillofac Surg Clin North Am. 2023;35(1):139–152.
- Prasetyo A.D., Wang Y., Kim S. Hyaluronic acid fillers with cohesive polydensified matrix for soft-tissue augmentation. Plast Aesthet Res. 2016;3:219–227.
- Li Q., Tang Y., Chen R. Chin augmentation with hyaluronic acid: a retrospective study of 326 cases. Dermatol Surg. 2022;48(7):888–895.
- Ширшакова М.А. Реологические свойства филлеров Belotero – залог оптимальной тканевой интеграции. Косметика и медицина. 2022;21(1):46–52. [Shirshakova M.A. Rheological properties of Belotero fillers are the key to optimal tissue integration. Cosmetics and Medicine. 2022;21(1):46–52. (In Russ.)].
- Гутовски К.А. Филлеры на основе гиалуроновой кислоты: научные и клинические применения. Клиническая пластическая хирургия. 2016;43(3):489–496. [Gutowski K.A. Hyaluronic acid fillers: scientific and clinical applications. Klinicheskaya i plasticheskaya khirurgiya. 2016;43(3):489–496. (In Russ.)].
- Моржанаева М.А., Свечникова Е.В. Метод восстановления внеклеточного матрикса с помощью заместительной коллагенотерапии препаратом Linerase. Фарматека. 2024;5:92–101. [Morzhanaeva M.A., Svechnikova E.V. Method of extracellular matrix restoration using collagen replacement therapy with Linerase. Farmateka. 2024;5:92–101. (In Russ.)]. https://dx.doi.org/10.18565/pharmateca.2024.5.92-101
- Haykal D., Sattler S., Verner I., Madhumita M., Cartier H. A Systematic Review of High-Intensity Focused Ultrasound (HIFU) in Skin Tightening and Body Contouring. Aesthet Surg J. 2025 Apr 4:sjaf053. doi: 10.1093/asj/sjaf053. Epub ahead of print. PMID: 40184185.
- Samizadeh S. Thread lifting – the fundamentals. PMFA Journal. 2022;9(1):14–20.
- Юцковская Я.А., Сатыго Е.А., Николаев А.В. и др. Консенсус по алгоритму комплексной оценки и коррекции нижней трети лица. Пластическая хирургия и эстетическая медицина. 2023;(3):93–109. [Yutskovskaya Y.A., Satygo E.A., Nikolaev A.V., et al. Consensus on the algorithm of complex assessment and correction of the lower third of the face. Plastic Surgery and Aesthetic Medicine. 2023;(3):93–109. (In Russ.)]. https://doi.org/10.17116/plast.hirurgia202303193
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