Biodegradable porous scaffolds for the bone tissue regeneration

Abstract

Scaffolds made of recombinant spidroin and fibroin of Bombix mori silk were produced by the salt leaching technique. The regenerative properties of scaffold were evaluated in experiments with rats by implantation into bone wounds. According to the X-ray tomography data, the use of both types of biocompatible materials provides the restoration of the integrity of a bone. By analyzing the dynamics of regeneration, it was found that the use of spidroin leads to more rapid regeneration of bone tissue in the defect area as compared to silk fibroin.