Total alopecia and vascular malformation: a random association or a prognostic factor?

Cover Page

Cite item

Full Text

Abstract

Background. Alopecia areata (AA) is a chronic recurrent autoimmune disease that leads to a deterioration in the quality of life. And capillary malformation (CM) occurs in 1/3 of AA patients.

Aim. To identify the connection of one of the forms of AA with CM in the occipital region.

Materials and methods. 18 patients with total alopecia (TA), 5 men and 13 women were under observation. The age ranged from 26 to 58 years, the duration of the disease ranged from 1 to 29 years. To determine the relationship between CM and TA, the odds ratio was used with the corresponding 95% confidence intervals.

Results. The study showed the occurrence of CM in patients with TA in 94.4%. The correlation of CM and TA turned out to be statistically significant in comparison with the control group.

Conclusion. The results indicate that there is a reliable relationship between CM and TA, which allows us to conclude that CM is associated with severe forms of alopecia. In addition, CM can be a valuable marker and prognostic factor indicating the development of more severe forms and course of AA.

About the authors

Igor Yu. Golousenko

Yevdokimov Moscow State University of Medicine and Dentistry

Author for correspondence.
Email: igor_golousenko5@mail.ru
ORCID iD: 0000-0002-1222-0356

D. Sci. (Med.)

Russian Federation, Moscow

Anton M. Solovyov

Yevdokimov Moscow State University of Medicine and Dentistry

Email: doctorsolovyov@mail.ru
ORCID iD: 0000-0003-3113-8929

Cand. Sci. (Med.)

Russian Federation, Moscow

Fedor A. Solovev

Yevdokimov Moscow State University of Medicine and Dentistry

Email: igor_golousenko5@mail.ru
ORCID iD: 0000-0002-2551-437X

Student

Russian Federation, Moscow

References

  1. Hordinsky MK. Overview of alopecia areata. J Investig Dermatol Symp Proc. 2013;16(1):S13-5.
  2. Gilhar A, Etzioni A, Paus R. Alopecia areata. N Engl J Med. 2012;366(16):1515-25.
  3. Bertolini M, Zilio F, Rossi A, et al. Abnormal interactions between perifollicular mast cells and CD8+ T-cells may contribute to the pathogenesis of alopecia areata. PLoS One. 2014;9(5):e94260.
  4. Sellami R, Masmoudi J, Ouali U, et al. The relationship between alopecia areata and alexithymia, anxiety and depression: a case-control study. Indian J Dermatol. 2014;59(4):421.
  5. Rencz F, Gulacsi L, Pentek M, et al. Alopecia areata and health-related quality of life: a systematic review and meta-analysis. Br J Dermatol. 2016;175(3):561-71.
  6. Kassira S, Korta DZ, Chapman LW, et al. Review of treatment for alopecia totalis and alopecia universalis. Int J Dermatol. 2017;56(8):801-10.
  7. Villasante Fricke AC, Miteva M. Epidemiology and burden of alopecia areata: a systematic review. Clin Cosmet Investig Dermatol. 2015;8:397-403.
  8. Richter GT, Friedman AB. Hemangiomas and vascular malformations: current theory and management. Int J Pediatr. 2012;2012:645-78.
  9. Hatzis J, Kostakis P, Tosca A, et al. Nuchal nevus flammeus as a skin marker of prognosis in alopecia areata. Dermatologica. 1988;177(3):149-51.
  10. Camacho F, Navas J. Nuchal nevus flammeus in alopecia areata. Dermatology. 1992;184:158.
  11. Akhyani M, Farnaghi F, Seirafi H, et al. The association between nuchal nevus flammeus and alopecia areata: a case-control study. Dermatology. 2005;211(4):334-7.

Supplementary files

Supplementary Files
Action
1. JATS XML
2. Fig. 1

Download (243KB)
3. Fig. 2

Download (209KB)

Copyright (c) 2022 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Согласие на обработку персональных данных

 

Используя сайт https://journals.rcsi.science, я (далее – «Пользователь» или «Субъект персональных данных») даю согласие на обработку персональных данных на этом сайте (текст Согласия) и на обработку персональных данных с помощью сервиса «Яндекс.Метрика» (текст Согласия).