Virucidal efficacy of cetylpyridinium chloride and benzydamine hydrochloride fixed combination lozenges against influenza A virus: A review
- Authors: Filippova O.V.1
-
Affiliations:
- Sechenov First Moscow State Medical University (Sechenov University)
- Issue: Vol 24, No 9 (2022)
- Pages: 588-594
- Section: Articles
- URL: https://journal-vniispk.ru/2075-1753/article/view/120374
- DOI: https://doi.org/10.26442/20751753.2022.9.201857
- ID: 120374
Cite item
Full Text
Abstract
Cetylpyridinium chloride (CPC) is effective against respiratory viruses, including influenza. Septolete® Total, lozenges containing CPC and benzydamine, demonstrated virucidal activity against influenza A virus, higher than CPC alone.
Keywords
Full Text
##article.viewOnOriginalSite##About the authors
Olga V. Filippova
Sechenov First Moscow State Medical University (Sechenov University)
Author for correspondence.
Email: ffiona@mail.ru
ORCID iD: 0000-0001-9470-6335
D. Sci. (Med.)
Russian Federation, MoscowReferences
Supplementary files
Supplementary Files
Action
1.
JATS XML
2.
Figure 1. Transmission (transmission) electron microscopy (TEM) demonstrates that CPC disrupts the integrity of the viral envelope and the morphology of the influenza virus: a - raw influenza virus; b, c – influenza virus treated with 50 μg/ml CPC for 5 min. The scale is located in the lower left corner at a distance of 100 nm (a) or 50 nm (b, c) [8].
Download (87KB)
3.
Figure 2. Release of influenza nucleoproteins from the virus in response to an increase in CPC [8].
Download (75KB)
4.
Figure 3. Influenza A virus exposure of the test substance at the highest concentration (equivalent to a solution of 1 lozenge in 4 ml suspension) at three different contact times.
Download (152KB)
5.
Figure 4. Comparison of the reduction in infectious viruses at the highest concentration (equivalent to a solution of 1 lozenge in 4 ml suspension) at three different exposure times.
Download (103KB)
