Combined pathology of various organs and systems in children with congenital hoan atresia

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Abstract

Background. Choana atresia is a "red flag" diagnosis that requires further examination for possible concomitant abnormalities, as children with this condition often have complex comorbidities that can significantly affect their prognosis, treatment options, and anesthetic risks.

Aim. To evaluate the structure of concomitant pathology in children with congenital choanal atresia.

Materials and methods. The study included 114 patients aged 1 month to 18 years who were admitted to the Otorhinolaryngology Department of the Research Clinical Institute of Pediatrics named after Academician Yu.E. Veltishchev of the Pirogov Russian National Research Medical University with a diagnosis of choana atresia.

Results. 114 children (69 girls and 45 boys) were treated and observed for AC, the average follow-up period was 36 months. Almost all children have certain pathological conditions in the ENT organs or other organs and systems.

Conclusion. The results of the study, conducted on a sufficient number of patients, show that congenital choanal atresia is often associated with both hereditary genetic conditions and other isolated abnormalities.

About the authors

Alan I. Asmanov

Pirogov Russian National Research Medical University

Email: Alan-asmanov@yandex.ru
ORCID iD: 0000-0002-3116-6447

Cand. Sci. (Med.)

Russian Federation, Moscow

Natalya D. Pivneva

Pirogov Russian National Research Medical University

Author for correspondence.
Email: pivnevand@yandex.ru
ORCID iD: 0000-0003-3673-9272

Cand. Sci. (Med.)

Russian Federation, Moscow

Olga I. Belova

Pirogov Russian National Research Medical University

Email: pivnevand@yandex.ru
ORCID iD: 0009-0003-2893-1413

Cand. Sci. (Med.)

Russian Federation, Moscow

References

  1. Hengerer AS, Brickman TM, Jeyakumar A. Choanal atresia: Embryologic analysis and evolution of treatment, a 30-year experience. Laryngoscope. 2008;118(5):862-6. doi: 10.1097/MLG.0b013e3181639b91
  2. Eitan D, Bhuskute A, Scheffler P. Incidence of airway abnormalities in children with craniosynostosis. J Craniofac Surg. 2024;35(1);192-3. doi: 10.1097/SCS.0000000000009793
  3. Котова Е.Н., Богомильский М.Р. Синдром CHARGE у детей с врожденной атрезией хоан. Вестник оториноларингологии. 2022;87(3):7-12 [Kotova EN, Bogomilsky MR. CHARGE syndrome in children with congenital choanal atresia. Russian Bulletin of Otorhinolaryngology. 2022;87(3):7-12 (in Russian)]. doi: 10.17116/otorino2022870317

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2. Fig. 1. Simultaneous operations in patients with congenital heart disease, %.

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3. Fig. 2. A child with MVPR and DAH.

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4. Fig. 3. A child with CHARGE syndrome 20 days of life with congenital DAX.

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