Mechanisms of chronic pain development. Approaches to prevention and treatment

Cover Page

Cite item

Full Text

Abstract

Presents data on the role of neurobiological, psychological and social factors in the pathogenesis of chronic pain. Chronic pain is considered not as a symptom of tissue damage, and as an independent disease arising from dysfunction of systems involved in the regulation of pain sensitivity. The complex pathophysiological basis of chronic pain syndrome requires a comprehensive approach in its treatment with the use of individualized programs of specialized pain centers.

About the authors

M. L Kukushkin

Research Institute of General Pathology and Pathophysiology; I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation

Email: mkuk57@gmail.com
д-р мед. наук, проф., ФГБНУ НИИОПП, ФГАОУ ВО «Первый МГМУ им. И.М.Сеченова» 125315, Russian Federation, Moscow, ul. Baltiiskaia, d. 8; 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 2

References

  1. Каратеев А.Е., Насонов Е.Л., Яхно Н.Н. и др. Клинические рекомендации «Рациональное применение нестероидных противовоспалительных препаратов (НПВП) в клинической практике». Соврем. ревматология. 2015; 1: 4-23.
  2. Кукушкин М.Л., Хитров Н.К. Общая патология боли. М.: Медицина, 2004.
  3. Осипов А.В., Кукушкин М.Л. Влияние стресса на развитие деафферентационного болевого синдрома у крыс после перерезки седалищного нерва. Бюл. экспериментальной биологии и медицины. 1993; 115 (5): 471-3.
  4. Пшенникова М.Г., Смирнова В.С., Графова В.Н. и др. Устойчивость к развитию невропатического болевого синдрома у крыс линии август и популяции вистар, обладающих разной врожденной устойчивостью к стрессовому воздействию. Боль. 2008; 2: 13-6.
  5. Боль (практическое руководство для врачей). Под ред. Н.Н.Яхно, М.Л.Кукушкина. М.: Изд - во РАМН, 2011.
  6. Яхно Н.Н., Кукушкин М.Л. Хроническая боль: медико - биологические и социально - экономические аспекты. Вестн. РАМН. 2012; 9: 54-8.
  7. Breivik H, Collett B, Ventafridda V et al. Survey of chronic pain in Europe: Prevalence, impact on daily life, and treatment. Eur J Pain 2006; 10: 287-333.
  8. Buskila D. Genetics of chronic pain states. Best Pract Res Clin Rheumatol 2007; 21: 535-47.
  9. Buskila D, Sarzi-Puttini P, Ablin J.N. The genetics of fibromyalgia syndrome. Pharmacogenomic 2007; 8: 67-74.
  10. Ceccarelli G et al. Flupirtine: the first Italian experience. Postgrad Med J 1987; 63 (Suppl. 3): 105-8.
  11. Classification of chronic pain: descriptions of chronic pain syndromes and definitions of pain terms/prepared by International Association for the Study of Pain, Task Force on Taxonomy; editors H.Merskey, N.Bogduk. 2nd ed. Seattle: IASP Press, 1994.
  12. Diatchenko L, Slade G.D, Nackley A.G et al. Genetic basis for individual variations in pain perception and the development of a chronic pain condition. Hum Mol Genet 2005; 14 (1): 135-43.
  13. Devulder J. Flupirtine in pain management: pharmacological properties and clinical use. CNS Drugs 2010; 24 (10): 867-81.
  14. Edwards R.R. Genetic predictors of acute and chronic pain. Curr Rheumatol Rep 2006; 8: 411-7.
  15. Finnerup N.B, Attal N, Haroutounian S et al. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta - analysis. Lancet Neurol 2015; 14: 162-73.
  16. Global Burden of Disease Study 2013 Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 2015; 386 (9995): 743-800.
  17. Harish S et al. Flupirtine: Clinical pharmacology. J Anaesthesiol Clin Pharmacol 2012; 28 (2): 172-7.
  18. Inutsuka A, Yamashita A, Chowdhur S et al. The integrative role of orexin/hypocretin neurons in nociceptive perception and analgesic regulation. Scientific Reports 2016; 6: 29480. doi: 10.1038/srep29480
  19. Jetzer A.K, Morel A, Magnin M, Jeanmonod D. Cross - modal plasticity in the human thalamus: evidence from intraoperative macrostimulations. Neuroscience 2009; 164: 1867-75.
  20. Klinger F, Bajric M, Salzer I et al. Subunit - containing GABAa receptors are preferred targets for the centrally acting analgesic flupirtine. Br J Pharmacol 2015; 172: 4946-58.
  21. Lacroix-Fralish M.L, Mogil J.S. Progress in genetic studies of pain and analgesia. Annu Rev Pharmacol Toxicol 2009; 49: 97-121.
  22. Li C, Ni J, Wang Z et al. Analgesic efficacy and tolerability of flupirtine vs. tramadol in patients with subacute low back pain: a double - blind multicentre trial. Curr Med Res Opin 2008; 24 (12): 3523-30.
  23. Mastronardi P et al. Analgesic activity of flupirtine maleate: a controlled double - blind study with diclofenac sodium in orthopaedics. J Int Med Res 1988; 16 (5): 338-48.
  24. Ringe J.D et al. Analgesic efficacy of flupirtine in primary care of patients with osteoporosis related pain. A multivariate analysis. Arzneimittelforschung 2003; 53 (7): 496-502.
  25. Seifert F, Maihöfner C. Functional and structural imaging of pain - induced neuroplasticity. Curr Opin Anaesthesiol 2011; 24: 515-23.
  26. Siegmund W et al. Metabolic activation and analgesic effect of flupirtine in healthy subjects, influence of the polymorphic NAT2, UGT1A1 and GSTP1. Br J Clin Pharmacol 2015; 79 (3): 501-13. doi: 10.1111/bcp.12522
  27. Thapa D et al. Effect of preoperative flupirtine on postoperative morphine sparing in patients undergoing total abdominal hysterectomy. Saudi J Anaesth 2016; 10 (1): 58-63.
  28. Uberall M.A, Essner U, Müller-Schwefe G.H. 2-week efficacy and tolerability of flupirtine MR and diclofenac in patients with acute low/back pain - results of a post - hoc subgroup analysis of patient - level data from four non - interventional studies. MMW Fortschr Med 2013; 155 (Suppl. 4): 115-23.
  29. Uberall M.A, Mueller-Schwefe G.H, Terhaag B. Efficacy and safety of flupirtine modified release for the management of moderate to severe chronic low back pain: results of SUPREME, a prospective randomized, double - blind, placebo - and active - controlled parallel - group phase IV study. Curr Med Res Opin 2012; 28 (10): 1617-34.
  30. Wall and Melzack’s Textbook of Pain. 5th Edition. S.B. Mc Mahon, M. Koltzenburg (Eds). Elsevier Churchill Livingstone, 2005.
  31. Welsch P, Sommer C, Schiltenwolf M, Häuser W. [Opioids in chronic noncancer pain - are opioids superior to nonopioid analgesics? A systematic review and meta - analysis of efficacy, tolerability and safety in randomized head - to - head comparisons of opioids versus nonopioid analgesics of at least four week's duration]. Schmerz 2015; 29 (1): 85-95. doi: 10.1007/s00482-014-1436-0
  32. Yamamoto T, Nozaki-Taguchi N, Chiba T. Analgesic effect of intrathecally administered orexin - A in the rat formalin test and in the rat hot plate test. Br J Pharmacol 2002; 137: 170-6.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2017 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Согласие на обработку персональных данных

 

Используя сайт https://journals.rcsi.science, я (далее – «Пользователь» или «Субъект персональных данных») даю согласие на обработку персональных данных на этом сайте (текст Согласия) и на обработку персональных данных с помощью сервиса «Яндекс.Метрика» (текст Согласия).