Characteristic property of molecular and biological mechanisms of Antareit antacid: multiplicity of therapeutic effects

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Abstract

Antareit is a combination of magaldrate (new generation antacid) with simeticone (anti-foaming agent used to reduce bloating). Magaldrate anti-acid effect develops quickly (in 1-2 minutes) and preserves for a long time (up to 3 hours). Magaldrate is a multitarget antacid that has adsorbing, enveloping and significant cytoprotective effect on gastric mucosa. When magaldrate dissolves in hydrochloric acid its crystal structure provides forming of tightly-packed hexaaquaaluminium particles. These particles envelop the ulceration area and their size (2 µm) enables epithelial cells and fibroblasts migration in gastric wall reparation process. As a result prostaglandin metabolism is modulated, nitrogen oxide vasodilatator level increases, tissue microcirculation improves and antihistamine effects manifest. These processes are important components of multitarget magaldrate effect.

About the authors

O. A Gromova

Federal Research Centre "Information and Management" of the Russian Academy of Sciences

Email: unesco.gromova@gmail.com
д-р мед. наук, проф., вед. науч. сотр., науч. рук. Института фармакоинформатики 119333, Russian Federation, Moscow, ul. Vavilova, d. 40

I. Yu Torshin

Federal Research Centre "Information and Management" of the Russian Academy of Sciences

канд. физ.-мат. наук, канд. хим. наук, ст. науч. сотр. 119333, Russian Federation, Moscow, ul. Vavilova, d. 40

V. A Maksimov

Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation

д-р мед. наук, проф., засл. деятель науки РФ, засл. врач РФ, вице-президент научного общества гастроэнтерологов России, проф. каф. диетологии и нутрициологии 125993, Russian Federation, Moscow, ul. Barrikadnaia, d. 2/1

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