Acute conditions in dermatology: toxic reactions and their treatment

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Abstract

Acute severe conditions caused by the use of various drugs are of particular difficulty in dermatological practice. Toxicodermic reactions include DRESS syndrome, Stevens–Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis and erythroderma of various origins. These disorders are characterized not only by skin lesions, but also toxic reactions in internal organs, which if untreated properly can be life-threatening. The first choice drugs for such reactions are systemic glucocorticosteroids, in particular betamethasone derivatives. Our own experience and numerous studies confirm the effectiveness of such drugs. However, it should be remembered that uncontrolled or prolonged use of systemic glucocorticosteroids can aggravate the patient's condition and lead to unwanted adverse reactions.

About the authors

Luiza R. Sakaniya

Center for Theoretical Problems of Physicochemical Pharmacology; Moscow Scientific and Practical Center of Dermatology, Venereology and Cosmetology

Email: marykor@bk.ru
ORCID iD: 0000-0003-2027-5987

dermatologist, 

Russian Federation, Moscow; Moscow

Kristina T. Plieva

Moscow Scientific and Practical Center of Dermatology, Venereology and Cosmetology

Email: marykor@bk.ru
ORCID iD: 0000-0001-9351-1034

dermatologist

Russian Federation, Moscow

Elena V. Denisova

Center for Theoretical Problems of Physicochemical Pharmacology; Moscow Scientific and Practical Center of Dermatology, Venereology and Cosmetology

Email: marykor@bk.ru
ORCID iD: 0000-0002-4887-284X

Cand. Sci. (Med.)

Russian Federation, Moscow; Moscow

Irina M. Korsunskaya

Center for Theoretical Problems of Physicochemical Pharmacology; Moscow Scientific and Practical Center of Dermatology, Venereology and Cosmetology

Author for correspondence.
Email: marykor@bk.ru
ORCID iD: 0000-0002-6583-0318

D. Sci. (Med.), Prof.

Russian Federation, Moscow; Moscow

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