Expression of Pgp in cells of neurovascular unit in perinatal hypoxic-ischemic brain injury
- Authors: Morgun A.V.1, Taranushenko T.E.1, Malinovskaya N.A.1, Okuneva O.S.1, Ustinova S.I.1, Karpova L.N.1, Salmina A.B.1, Pozhilenkova E.A.1, Laletin D.I.1, Frolova O.V.1, Reusheva N.V.1, Trufanova L.V.1
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Affiliations:
- Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
- Issue: Vol 8, No 1 (2014)
- Pages: 40-43
- Section: Original articles
- URL: https://journal-vniispk.ru/2075-5473/article/view/124618
- DOI: https://doi.org/10.17816/psaic192
- ID: 124618
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Full Text
Abstract
We have studied peculiarities of P-glycoprotein (Pgp) expression on neuronal, astroglial and endothelial cells in newborn rats (P10) underwent perinatal hypoxic-ischemic brain damage. Expression of Pgp was markedly elevated in all the cells tested reaching the highest levels in astrocytes (4 hrs after injury) followed by increased levels in neuronal and endothelial cells (12 hrs after injury). The possible role of Pgp in pathogenesis of perinatal brain injury is discussed.
About the authors
A. V. Morgun
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: reg.kgmu@gmail.com
Russian Federation, Krasnoyarsk
T. E. Taranushenko
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: reg.kgmu@gmail.com
Russian Federation, Krasnoyarsk
N. A. Malinovskaya
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: reg.kgmu@gmail.com
Russian Federation, Krasnoyarsk
O. S. Okuneva
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: reg.kgmu@gmail.com
Russian Federation, Krasnoyarsk
S. I. Ustinova
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: reg.kgmu@gmail.com
Russian Federation, Krasnoyarsk
L. N. Karpova
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: reg.kgmu@gmail.com
Russian Federation, Krasnoyarsk
A. B. Salmina
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: reg.kgmu@gmail.com
Russian Federation, Krasnoyarsk
E. A. Pozhilenkova
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: reg.kgmu@gmail.com
Russian Federation, Krasnoyarsk
D. I. Laletin
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: reg.kgmu@gmail.com
Russian Federation, Krasnoyarsk
O. V. Frolova
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: reg.kgmu@gmail.com
Russian Federation, Krasnoyarsk
N. V. Reusheva
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Email: reg.kgmu@gmail.com
Russian Federation, Krasnoyarsk
L. V. Trufanova
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Author for correspondence.
Email: reg.kgmu@gmail.com
Russian Federation, Krasnoyarsk
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