Email this article Specific Features of Apoptotic Signaling Regulation in Cells Infected with Cytomegalovirus and Epstein–Barr Virus
- Authors: Sakharnov N.A.1, Utkin O.V.1,2, Knyazev D.I.1, Filatova E.N.1, Tsvetkova V.D.1
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Affiliations:
- Blokhina Institute of Epidemiology and Microbiology
- Nizhny Novgorod State Medical Academy
- Issue: Vol 8, No 2 (2018)
- Pages: 114-123
- Section: Article
- URL: https://journal-vniispk.ru/2079-0864/article/view/206764
- DOI: https://doi.org/10.1134/S207908641802007X
- ID: 206764
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Abstract
A large proportion of global population is infected with lymphotropic herpesviruses—cytomegalovirus (CMV) and Epstein–Barr virus (EBV). The products of CMV and EBV gene expression influence various elements of the apoptosis signaling pathways in infected cells and result in successful virus persistence. Some specific features in the interaction of CMV and EBV proteins and RNA transcripts with cellular proteins of apoptosis signaling pathways are considered. The review focuses on the structural and functional elements of the apoptosis-associated signaling pathways that are affected by these viruses.
About the authors
N. A. Sakharnov
Blokhina Institute of Epidemiology and Microbiology
Author for correspondence.
Email: saharnov@nniiem.ru
Russian Federation, Nizhny Novgorod
O. V. Utkin
Blokhina Institute of Epidemiology and Microbiology; Nizhny Novgorod State Medical Academy
Email: saharnov@nniiem.ru
Russian Federation, Nizhny Novgorod; Nizhny Novgorod
D. I. Knyazev
Blokhina Institute of Epidemiology and Microbiology
Email: saharnov@nniiem.ru
Russian Federation, Nizhny Novgorod
E. N. Filatova
Blokhina Institute of Epidemiology and Microbiology
Email: saharnov@nniiem.ru
Russian Federation, Nizhny Novgorod
V. D. Tsvetkova
Blokhina Institute of Epidemiology and Microbiology
Email: saharnov@nniiem.ru
Russian Federation, Nizhny Novgorod
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