Rol' predstaviteley semeystva transformiruyushchego faktora rosta beta v otsenke ovarial'nogo rezerva u zhenshchin s prezhdevremennoy nedostatochnost'yu yaichnikov


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Abstract

Преждевременная недостаточность яичников (ПНЯ) - это симптомокомплекс, характеризующийся вторичной аменореей, симптомами дефицита половых гормонов на фоне повышения уровня гонадотропинов (фолликулостимулирующий гормон - ФСГ, лютеинизирующий гормон - ЛГ) у женщин в возрасте до 40 лет [19]. Частота данной патологии колеблется от 1 до 3% [26] и составляет 10% в структуре вторичной аменореи [1, 29]. В большинстве случаев природа ПНЯ не ясна [19, 36]. Это состояние описывается как многофакторный синдром, в развитии которого могут принимать участие хромосомные, генетические, аутоиммунные, инфекционно-токсические, ятрогенные, психологические факторы, дефекты в структурах гонадотропинов и ферментопатии [8, 15]. Независимо от этиологического фактора в основе ПНЯ лежит не свойственное этому возрастному периоду уменьшение запаса примордиальных фолликулов, вплоть до его полного истощения и формирования афолликулярного типа ПНЯ.

About the authors

L A Marchenko

ГУ НЦАГиП РАМН (ГУ Научный центр акушерства, гинекологии и перинатологии РАМН, Москва

N V Aleksandrova

ГУ НЦАГиП РАМН (ГУ Научный центр акушерства, гинекологии и перинатологии РАМН, Москва

References

  1. Anasti J.N. Premature ovarian failure: an update. Fertil Steril 1998; 70: 1-15.
  2. Arango N.A, Lovell-Badge R, Behringer R.R. Targeted mutagenesis of the endogenous mouse Mis gene promoter: in vivo definition of genetic pathways of vertebrate sexual development. Cell 1999; 99: 409-19.
  3. Baarends W.M, Uilenbroek J.T, Kramer P et al. Anti - mullerian hormone and anti - mullerian hormone type II receptor messenger ribonucleic acid expression in rat ovaries during postnatal development, the estrous cycle, and gonadotropin - induced follicle growth. Endocrinology 1995; 136: 4951-62.
  4. Behringer R.R, Finegold M.J, Cate R.L. Miillerian - inhibiting substance function during mammalian sexual development. Cell 1995; 79: 415-25.
  5. Bukman A, Heineman M.J et al.Ovarian reserve testing and the use of prognostic models in patient with subfertility human Reproduction Update 2001; 7 (6): 581-90.
  6. Bulun S.E. Clinical review 78: aromatase deficiency in women and men: would you have predicted the phenotypes? J Clin Endocrinol Metab 1996; 81: 867-71.
  7. Burger H.G, Cahir N, Robertson D.M et al. Serum inhibin A and B fall differentially as FSh rise in perimenopausal women. Clin Endocrinol (Oxf) 1998; 48: 809-13.
  8. Conway G.S, Katlas G, Patel et al. Characterization of idiopathic premature ovarian failure. Fertil Steril 1996; 65: 337-41.
  9. Cramer D.W. Epidemiologic aspects of early menopause and ovarian cancer. Ann NY Acad Sci 1990; 592: 363-75.
  10. De Paolo L.V, Ricsak T.A, Erickson G.F et al. Follistalin and activin: A potential intrinsic regulatory system within diverse tissues. Proc Soc Exp Biol Med 1991; 198: 500-12.
  11. Durlinger A.L, Gruijters M.J, Kramer P et al. Anti - mullerian hormone attenuates the effects of FSH on follicle development in the mouse ovary. Endocrinology 2001; 142: 4891-9.
  12. Durlinger A.L, Kramer P, Karels B et al. Control of primordial follicle recruitment by anti-Mullerian hormone in the mouse ovary. Endocrinology 1999; 140: 5789-96.
  13. Fancin R, Schonauer L.M et al. Serum anti-Mullerian hormone is more strongly related to ovarian follicular status than inhibin B, estradiol, FSH and LH on day 3. Hum Reproduct 2003; 18 (2): 323-7.
  14. Fraser H.M, Tsonis C.G. Manipulation of inhibin during the lutheal - follicular phase transition of the primate menstrual cycle fails to affect FSH secretion. J Endocrinol 1994; 142: 181-6.
  15. Howel S, Shalet S, Gonadal damage from chemotherapy and radiotherapy. Endocrinol Methab Clin Noth Am 1998; 27: 927-43.
  16. Jost A. Recherches sur la differenciation sexuelle de I'embryon de lapin. Arch Anal Microsc Morphol Exp 1947; 36: 271-315.
  17. Klein N.A, Illingworth P.J, Mc Neilly A.S et al. Decreased inhibin B secretion is associated with the monotropic FSH rise in older, ovulatory women: a study of serum and follicular fluid levels of dimeric inhibin A and B in spontaneous menstrual cycles. J Clin Endocrin Metab 1996; 81: 2742-5.
  18. Lahlou N, Chabbert-Buffet N, Cristin-Maitre S et al. Main inhibitor of follicle - stimulatin hormone in the lutheal - follicle transition: inhibin A, estradiol, or inhibin B? Hum Reprod 1999; 14: 1190-3.
  19. Lamp T, Schultz-Lobmeyr I, Obruca A et al. Premature ovarian failure: etiology and prospects. Gynecol Endocrinol 2000; 14: 292-302.
  20. Latronico A.C, Anasti J, Atnhold I.J.P et al. Brief report: teasticular and ovarian resistance to luteinizing hormone caused by inactivating mutations of the luteinizing hormone - receptor gene. N Eng J Med 1996; 334: 507-12.
  21. Le Nestour E, Marraoui J, Lahlou N et al. Role of estradiol in the rise in the follicle - stimulating hormone levels during the lutheal - follicular transition. J Clin Endocrinol Metab 1993; 77: 439-42.
  22. Lee M.M, Donahoe P.K. Muillerian inhibiting substance: a gonadal hormone with multiple functions. Endocr Rev 1993; 14: 152-64.
  23. Licciardi F.L, Liu H.C, Rosenwaks Z. Day 3 estradiol serum concentrations as prognosticators of ovarian stimulation response and pregnancy outcome in patients undergoing in vitro fertilization. Fertil Steril 1995; 64: 991-4.
  24. Ling N,Ying S.Y, Ueno N et al. Pituitary FSH is released by a heterodimer of the beta - subunits from the two forms of inhibin. Nature 1986; 321: 779-82.
  25. Lockwood G.M, Ledger W.L, Barlow D.H. Identification of the source of inhibins at the time of conception provides a diagnostic role for them in very early pregnancy. Am J Reprod Immimol 1998; 40: 303-8.
  26. Luborsky J.L, Meyer P et al. Premature menopause in a multiethnic population study of the menopause transition. Hum Reprod 2003; 18: 199-206.
  27. Magoffin D.A, Jakimiuk A.J. Inhibin A, Inhibin B and activin in the follicular fluid of regulatory cycling women. Hum Reprod 1997; 12: 1714-9.
  28. Meunier H, Rivier C, Evans R.M, Vale W. Gonadal and extragonadal expression of inhibin alpha, beta A, and beta U subunits in various tissues predicts diverse functions. Proc Ncitl Aciid Sci USA 1988; 85: 247-51.
  29. Moraes Ruhsen, M and Jones, G.S Premature ovarian failure Fertil Steril 1967; 18: 440-61.
  30. Muntz W, Mohamed E.H, Seufert R et al. Serum inhibin A, inhibin B, pro - a C and activin A levels in women with idiopathic premature ovarian failure. Fertil Steril 2004 Sep; 82 (3): 760-2.
  31. Nelson L.M, Anasti J.N, Kimzey L.M et al. Development of luteinized graaf follicles in patients with karyotipically normal spontaneous premature ovarian failure. J Clin Endocrinol Metab 1994; 79: 1470-5.
  32. Pangas S.A, Woodruff T.K. Activin signal transduction pathways. Trends Endocrinol Methab 2000; 11: 309-14.
  33. Petraglia F, Hartmann B, Luisi S. Loe levels of serum inhibin A and inhibin B in women with hypergonadotropic amenorrhea and evidence of high levels of activin A in women with hypothalamic amenorrhea. Fertil Steril 70 (5): 907-12.
  34. Piek E, Heldin C.H, Ten Dijke P. Specificity diversity, and regulation in TGF-beta superfamily signaling. FASEB J 1999; 13: 2105-24.
  35. Reame N.E, Wyman T.L, Phillips D.J et al. Net increase in stimulatory tone resulting from a decrease in inhibin-B and an increase in activin A may contribute, in part, to the rise in follicular fase FSH of aging in cycling women. J Clin Endocrinol Metab 1998; 83: 3302-7.
  36. Rebar R.W. Hypergonadotropic amenorrhea and premature ovarian failure: a review. J Reprod Med 1982; 4: 179-86.
  37. Richardson S.J, Senikas V, Nelson J.F. Follicular depletion during the menopausal transition: Evidence for accelerated loss and ultimate exhaustion. J Clin Endocrinol Metab 1987; 65: 1231-7.
  38. Roberts V.J, Barth S, EI-Roeiy A, Yen S.S.C. Expression of inhibin/activin subunits and follistatin messenger ribonucleic acids and proteins in ovarian follicles and the corpus luteum during the human menstrual cycle. J Clin Endocrinol Metab 1993; 77: 1402-10.
  39. Hofman S.G.E, Oehninger S et al. Intercycle variability of day 3 follicle - stimulating hormone levels and its effect on stimulation quality in vitro fertilization. Fertil Steril 1990; 54: 297-302.
  40. Seifer D.B, Lambert-Messerlian G, Hogan J.W et al. Day 3 serum inhibin-B is predictive of assisted reproductive technologies outcome. Fertil Steril 1997; 67: 110-4.
  41. Seifer D.B, Scott R.T, Bergh P.A et al. Women with declining ovarian reserve may demonstrate a decrease in day 3 serum inhibin B before a rise in follicle - stimulating hormone. Fertile Steril 1999; 72: 63-5.
  42. te Velde E.R, Pearson P.L. The variability of female reproductive aging. Hum Reprod Update 2002; 8: 141-54.
  43. te Vigier B, Picard J.Y, Tran D et al. Production of anti-Muillerian hormone: another homology between Sertoli and granulosa cells. Endocrinology 1984; 114: 1315-20.
  44. Vale W, Rivier J, Vaughan J et al. Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid. Nature 1986; 321: 776-9.
  45. van Rooij A.J, Broekmans J.M, Sheffer G.J. Serum antimulerian hormone levels best reflect the reproductive decline with age in normal women with proven fertility: a longitudinal study Fert Steril 2005; 8: 979-87.
  46. van Rooij I.A, Broekmans F.J, te Velde E.R et al. Serum antimullarian hormone levels: a novel measure of ovarian reserve. Hum Reprod 2002; 17: 3065-71.
  47. Welt C.K, Mc Nicholl D, Taylor A.E, Hall J.E. Female reproductive aging is marked by decreased secretion of dimeric inhibin. J Clin Endocrinol Metab 1999; 84: 105-11.
  48. Welt C.K, Pagan Y.L, Smith P.C et al. Control of follicle - stimulation hormone by estradiol and the inhibins: critical role of estradiol at the hypothalamus during the lutheal - follicular transition. J Clin Endocrinol Metab 2003; 88: 1766-71.
  49. Woodruff T.K, Mather J.P. Inhibin, activin and the female reproductive axis. Annu Rev Physiol 1995; 57: 219-44.

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