Predicting the effectiveness of hormone replacement therapy in postmenopausal osteoporotic changes correction


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Abstract

The paper presents a model for predicting the protective efficacy of hormone replacement therapy (HRT) on the basis of a comprehensive evaluation of mineral density and metabolic activity of bone tissue. A positive correlation between the ratio of the differential rates of accumulation, representing the ratio between the standardized rates of accumulation of the lumbar vertebrae and femoral neck, and increase bone mineral density (BMD) of the lumbar vertebrae (L2-L4) using HRT. Determined inverse relationship between the initial level of the BMD and its growth against the backdrop of 12 months of use of HRT drugs. Established predictive model will allow a reasonably prescribe HRT that will enhance the efficiency of correction postmenopausal osteoporotic changes and reduce the side effects associated with the use of this group of drugs.

About the authors

I S Zakharov

Kemerovo State Medical Academy of the Ministry of Health of the Russian Federation

Email: isza@mail.ru
канд. мед. наук, доц. каф. акушерства и гинекологии №1 ГБОУ ВПО КемГМА 650056, Russian Federation, Kemerovo, ul. Voroshilova, d. 22a

G I Kolpinskiy

Kemerovo State Medical Academy of the Ministry of Health of the Russian Federation

д-р мед. наук, проф. каф. лучевой диагностики, лучевой терапии и онкологии ГБОУ ВПО КемГМА 650056, Russian Federation, Kemerovo, ul. Voroshilova, d. 22a

G A Ushakova

Kemerovo State Medical Academy of the Ministry of Health of the Russian Federation

д-р мед. наук, проф., зав. каф. акушерства и гинекологии №1 ГБОУ ВПО КемГМА 650056, Russian Federation, Kemerovo, ul. Voroshilova, d. 22a

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