Season fluctuations of level of 25-hydroxycholecalciferol in pregnant women living in Saint Petersburg


Cite item

Full Text

Abstract

In this article there are shown cohort prospective research results of 25-hydroхуholecalciferol level estimation in blood serum during pregnancy among women depending on the season of the year. The aim of this research is to estimate the intensity of the body of pregnant women with vitamin D in different seasons during pregnancy, who live in Saint Petersburg. There are involved 205 pregnant at I trimester. It was finished by 192 patients. All patients were divided into 4 subgroups depending on the season of the year while involving to the study. At 12-14 weeks there was first blood sampling. From the I trimester till delivery all patients took 500 IU of сolecalciferol contained in multivitamin complexes. During pregnancy 25-ОН-D level in blood serum was measured at 12-14, 24-26, 34-36 weeks of gestation. There are not found significant differences of the initial mean level of 25-ОН-D in all pregnant (17.5, 21.3, 22.6, 19.9 ng/ml, accordingly to the 1st, 2nd, 3rd and 4th subgroups). It was defined the maximal intensity of vitamin D at I trimester of pregnancy during summer - 22.6 ng/ml, which refers to the criteria of vitamin D insufficiency. Minimal concentration of 25-ОН-D among subgroups was revealed during winter - 17.5 ng/ml, which refers the criteria of vitamin D deficiency. Total concentration of 25-ОН-D authentically does not differ between subgroups. The increase the level of 25-ОН-D from the I to the III trimester takes place regardless of the season. The study showed no significant changes in the level of 25-OH-D in blood serum of pregnant depending on the season.

About the authors

E L Khazova

V.A.Almazov Northwestern Federal Medical Research Center of the Ministry of Health of the Russian Federation

Email: kamishi77@mail.ru
науч. сотр. НИЛ репродукции и здоровья женщины Института перинатологии и педиатрии ФГБУ СЗФМИЦ им. В.А.Алмазова 197341, Russian Federation, Saint Petersburg, ul. Akkuratova, d. 2

L V Shirinyan

V.A.Almazov Northwestern Federal Medical Research Center of the Ministry of Health of the Russian Federation

канд. мед. наук, науч. сотр. НИЛ репродукции и здоровья женщины Института перинатологии и педиатрии ФГБУ СЗФМИЦ им. В.А.Алмазова 197341, Russian Federation, Saint Petersburg, ul. Akkuratova, d. 2

I E Zazerskaya

V.A.Almazov Northwestern Federal Medical Research Center of the Ministry of Health of the Russian Federation

д-р мед. наук, зав. каф. акушерства и гинекологии ФГБУ СЗФМИЦ им. В.А.Алмазова 197341, Russian Federation, Saint Petersburg, ul. Akkuratova, d. 2

V A Bart

V.A.Almazov Northwestern Federal Medical Research Center of the Ministry of Health of the Russian Federation

канд. физ.-мат. наук, зав. НИЛ математического моделирования ФГБУ СЗФМИЦ им. В.А.Алмазова 197341, Russian Federation, Saint Petersburg, ul. Akkuratova, d. 2

E Yu Vasilieva

V.A.Almazov Northwestern Federal Medical Research Center of the Ministry of Health of the Russian Federation

зав. центральной клинико-диагностической лаб. ФГБУ СЗФМИЦ им. В.А.Алмазова, ассистент каф. клинической лабораторной диагностики ФГБУ СЗФМИЦ им. В.А.Алмазова 197341, Russian Federation, Saint Petersburg, ul. Akkuratova, d. 2

References

  1. Karras S.N. Maternal vitamin D status during pregnancy: the Mediterranean reality. Eur J Clin Nutr 2014.
  2. Hollis B.W, Wagner C.L. Vitamin D requirements during lactation: high - dose maternal supplementation as therapy to prevent hypovitaminosis D for both the mother and the nursing infant. Am J Med 2004; 112:659-62.
  3. Lee J.M, Smith J.R, Philipp B.L et al. Vitamin D deficiency in a healthy group of mothers and newborn infants. Clin Pediatr (Phila) 2007; 46: 42-4; Am J Clin Nutr 80: 1752S-8S.
  4. Bodnar L.M, Simhan H.N, Powers R.W et al. High prevalence of vitamin D insufficiency in black and white pregnant women residing in the northern United States and their neonates. J Nutr 2007; 137: 447-52.
  5. Kasahara A.K, Singh R.J, Noymer A. Vitamin D (25OHD) Serum Seasonality in the United States. PLoS ONE 2013; 8(6): e65785. doi: 10.1371/journal.pone.0065785.
  6. De-Regil L.M, Palacios C, Ansary A et al. Cochrane Collaboration. Vitamin D supplementation for women during pregnancy. 2012.
  7. Evaluation, Treatment, and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline 2011.
  8. Holick M.F. Vitamin D deficiency. N Engl J Med 2009; 357: 266-81.
  9. Dawodu A, Saadi H.F, Bekdache G et al. Randomized controlled trial (RCT) of vitamin D supplementation in pregnancy in a population with endemic vitamin D deficiency. J Clin Endocrinol Metab 2013; 98: 2337-46.
  10. Haddad J.G, Matsuoka L.Y, Hollis B.W et al. Human plasma transport of vitamin D after its endogenous synthesis. J Clin Invest 1993; 91: 2552-5.
  11. Sardi B. The uncensored family guide live longer and healthier with 30 minutes. Knowledge of Health, Inc. 2008.
  12. ФГБУ «Северо-Западное управление по гидрометеорологии и мониторингу окружающей среды»
  13. Outila T. Department of Applied Chemistr and Microbiology Division of Nutrition University of Helsinki 2001 The effect of vitamin D status on calcium and bone metabolism.
  14. Royal College of Obstetricians and Gynaecologists, Vitamin D in pregnancy, Scientific Impact Paper No. 43 June 2014.
  15. Gordon C.M, De Peter K.C, Feldman H.A et al. Prevalence of vitamin D deficiency among healthy adolescents. Arch Pediatr Adolesc Med 2004; 158: 531-7.
  16. Sullivan S.S, Rosen C.J, Halteman W.A et al. Adolescent girls in Maine at risk for vitamin D insufficiency. J Am Diet Assoc 2005; 105: 971-4.
  17. Nesby-O’Dell S, Scanlon K.S, Cogswel M.E et al. Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: Third National Health and Nutrition Examination Survey, 1988-1994. Am J Clin Nutr 2002; 76: 187-92.
  18. Tangpricha V, Pearce E.N, Chen T.C, Holick M.F. Vitamin D insufficiency among free - living healthy young adults. 2002.
  19. Adams J.S, Hewison M. Update in vitamin D. J Clin Endocrinol Metab 2010; 95: 471-8.
  20. Holick M.F. Vitamin D deficiency. J Clin Endocrinol Metab 2011; N Engl J Med 2007; 357: 266-81.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2015 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Согласие на обработку персональных данных

 

Используя сайт https://journals.rcsi.science, я (далее – «Пользователь» или «Субъект персональных данных») даю согласие на обработку персональных данных на этом сайте (текст Согласия) и на обработку персональных данных с помощью сервиса «Яндекс.Метрика» (текст Согласия).