Clinical and immunological assessment of the state of the cervix after radiosurgical conization and medical prophylaxis of septic complications

Purpose of the study. Comprehensive assessment of the clinical and immunological changes in cervical epithelium and the vaginal microbiota in patients with cervical intraepithelial neoplasia (CIN) II-III stage after radiosurgical conization and the drug Neo-Penotran Forte L.Materials and methods. The study included 2 groups of sexually active women (n=143) aged 21 to 45 years (mean age - 34.5±6.5 years). They were examined for the presence of genital infections and vector-borne, liquid-based cytology, colposcopy. All patients were treated with radiosurgery method in the amount of conization.Results. Patients treated in the pre - and postoperative period with Neo-Forte Penotran A, were found to have a marked reduction of proinflammatory and anti-inflammatory cytokines increase. Median values analysis has allowed to ascertain the prevalence ofinterleukin indicators (IL)-1a and IL-b in the 2nd group over those in the 1st, when U (Mann-Whitney test)=5.9 and U=7.5, respectively, those p<0.001. Secretion of IL-2 in patients of group exceeded that of patients in Group 1: IL-1a - 2. 6 times and IL-b - 5 times. Results for liquid-based cytology showed no recurrence of CIN. Use of the Neo- Penotran Forte L improved the condition of the stratified squamous epithelium of the cervix according to colposcopic control. In particular, the phenomenon ofprevascular edema, inflammatory infiltration characteristic of coagulation necrosis in group 1 had a significantly less pronounced than in the 2nd: 8.9% (n=7) cases against 32.8% (n=21 ) - if f * (multi-Fischer test) = 3.72, p<0.000; femp *> *fcr. Conclusions.Use of the drug Neo-Penotran Forte L affects the key pathophysiological processes of septic complications, prevents their development and contributes to improved tissue repair in patients after radiosurgical treatment. An integrated pre - and post-operative treatment helps to improve the immune status of the vaginal microecology.

vaginal microecology, cervical intraepithelial neoplasia, Neo-Penotran Forte L, clinical and immunological assessment of cervical status